Triona Ní Chonghaile

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase

www.science.org/doi/10.1126/...

A fantastic viewpoint by @frezzalab.bsky.social network.febs.org/posts/thinki...

It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.

Congratulations to the recipients of the Nobel Prize in Physiology or Medicine 2025 - Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" including the identification of regulatory T cells

#NobelPrize #Tregs

@nobelprize.bsky.social 🧪🔬🏆

Congratulations, David @dchenshall.bsky.social. Well deserved.

🏆 Congratulations to our Director, Prof @dchenshall.bsky.social, on receiving the ILAE Ambassador for Epilepsy Award at the 36th International Epilepsy Congress in Lisbon—recognising his global impact on epilepsy research.

@ilae-epilepsy.bsky.social @researchireland.ie @epilepsyireland.bsky.social

Cells are swapping their mitochondria. What does this mean for our health? Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

Cells swapping their #mitochondria - this sounded like science fiction 🧪 when the first studies started coming out!

But now this has been observed in #cancer, #yeast, #molluscs, and under normal physiology - as a way to regulate energy demands, metabolism, cell fate & much more - true #powerhouses!

Thanks also to @profjochen.bsky.social @rcsi.bsky.social

Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure - Nature Communications Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy...

Huge congratulations to Andy on the publication of his PhD work! This was a massive team effort, thanks to the lab for helping out & collaborators: Ingmar Schoen, Emmar Kerr @mariemcilroy.bsky.social
Link here:
www.nature.com/articles/s41.... Thanks to funding from @researchireland.ie

Lovely paper Lydia. Congratulations to all the team.

Very excited about the first Irish Multiple Myeloma Meeting being held this September 12th!! Mark the calendars it should be a great meeting.

ApoList – April 2025 Bcl-2 family proteins Structural basis of BAK sequestration by MCL-1 in apoptosis Shagun Srivastava, Giridhar Sekar, Adedolapo Ojoawo, Anup Aggarwal, Elisabeth Ferreira, Emiko Uchikawa, Meek Yang, …

ApoList – April 2025 – Articles on apoptosis and cell death
With several articles about how mRNA splicing problems cause necroptosis by zDNA,
and about different outcomes of macrophages phagocytising apoptotic cells of different cell types (efferocytosis)
celldeath.wordpress.com/2025/05/06/a...

Chiacchiere

Congratulations to Dr. Ludovica Di Martino @rcsi.bsky.social for receiving the Prof. John Fitzpatrick award at the IACR meeting for her presentation on Multiple Myeloma. We celebrated with delicious Italian treats! Thanks to collaborator Prof. Siobhan Glavey @Beaumont RCSI Cancer Centre.

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

www.nature.com/articles/s41...

Thrilled our review was selected as a #science #highlight in this #Cell timeline of the last decade 🧪

"Embracing #cancer complexity: Hallmarks of systemic disease"

Swanton et al, 2024

www.sciencedirect.com/science/arti...

@charlesswanton.bsky.social
@cancerresearchuk.org
@cp-cell.bsky.social

Thanks to expat lab members, some traveling from afar, for showing up to celebrate Andy!

Huge congratulations to the newly minted Dr. Andy Roe on his viva 🎉!! Thanks so much to examiners @crismunozp.bsky.social and Dr. Niamh Connolly (not on Blue sky!) and the chair @christophertorrens.bsky.social @rcsi.bsky.social @rcsi-research.bsky.social. Looking forward to following your 💫 career.

Human HDAC6 senses valine abundancy to regulate DNA damage Nature - The histone deacetylase HDAC6 is a sensor of valine levels, and the abundance of valine in cells regulates DNA damage and cell homeostasis functions.

An interesting paper just published in Nature on HDAC6 as a valine sensor:
rdcu.be/d1waX

Ferroptosis—disease perils and therapeutic promise Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment

Our perspective in Science Magazine on #Ferroptosis—#disease perils and #therapeutic promise www.science.org/doi/10.1126/... written for a general audience -- not too technical. Congrats to authors Ashley Brown and Tal Hirschhorn!

Unfortunately, we have to postpone tomorrow’s webinar with Emma Farley. We will reschedule as soon as we can!