Harini Iyer

Don’t miss this amazing webinar tomorrow!

Don't miss out on this fantastic line-up of speakers at the Neural Disorders RIG meetup of the Zebrafish Disease Models Society! July 30, 10:00 EST. Registration details below:

Deepika Dogra, Karin Tuschl, and I are thrilled to host the Neural Disorders RIG meeting of the @ZDMSociety on July 30, 10:00-11:30 am ET. We have a fantastic line-up of speakers. Register here: zdmsociety.org/2025-zdms-ri....

If you think this is a good publishing experience, just wait until March. We’re announcing a game changing modification to peer review. Makes life better for editors, reviewers & especially authors

I'm thrilled to announce that our paper describing Marigold, a free machine learning-based webapp for zebrafish behavioral analysis, is officially published! Marigold features a user friendly graphical user interface to enable training of a neural network for analyzing behavioral recordings.

Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq Genetic association studies provide a unique tool for identifying causal links from genes to human traits and diseases. However, it is challenging to determine the biological mechanisms underlying mos...

GWAS provides a unique tool in human biology as it can establish causal links from variants to trait.

But interpretation is difficult as most effects flow through (unobserved) gene regulatory networks. Can we gain insight by linking to modern Perturb-seq data?

www.biorxiv.org/content/10.1...

Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature Communications Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...

New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠

www.nature.com/articles/s41...

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions Using a 3D co-culture system of iPSC-derived neurons and glia, termed iAssembloids, combined with CRISPRi-based screening, Li et al. investigate the effect of glial cells on neuronal activity and surv...

Our latest paper, led by Emmy Li, is out on Neuron today:

CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions

www.cell.com/neuron/fullt...

Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags!

www.biorxiv.org/content/10.1...

Ooohhh-that's our paper! Check it out! @noahgurley.bsky.social @emily-mcparland.bsky.social

Excited to see this out! A fantastic collaboration with Kirsten Sadler, spearheaded by Nouf and Talhah! Big thanks to DMM for highlighting our work as an Editors Choice, as well as the First Person Interview. 😀🔬🐟

Our new paper on recombinant tools for reversibly ablating excitatory and inhibitory synapses is out in eLife. Congrats to first author, Aida Bareghamyan!
elifesciences.org/reviewed-pre...

Plasmids, and hopefully AAVs, will be available soon on Addgene.

#Devbio folks, mark your calendars:
SWSDB2025 at UNM in Albuquerque, NM, May 2-4!

Organizers Drs. Mubarak Hussain Syed, Lomeli Shull, Tou Yia Vue, Alexa Burger, & Marycruz Flores-Flores as US-Mexico liaison - more tk on their fabulous website:
www.swsdb2025.org

@socdevbio.bsky.social #SWSDB2025

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

Thrilled to see this paper out!! 🧪

Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!

Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!

rdcu.be/d33uQ 🧵

There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...

Heading to #CellBio2024? Do you love #lipids? Join us for an exciting subgroup on Lipids in Organelle Form and Function, Saturday at 1:45 PM! Lipid-themed happy hour to follow but you must attend the session to find out the location!

Updated Aging Starter Packs to find people and labs who work on aging!!

Aging Starter Pack 1 (already reached the maximum number!): go.bsky.app/5UXXaDA

Aging Starter Pack 2 (can still add!): go.bsky.app/RfFYndJ

Let me know if you'd like to be added! 😀

Joey is such a fantastic person and a thoughtful and brilliant scientist! I would apply for a position in his lab if I was eligible!

I'll be presenting at #CellBio2024 on Monday, Dec. 16! I'll give a flash talk in the Cell Dynamics, Developmental and Structural Biology, and Signal Transduction microsymposium at 10 am and then will be at my poster 1:30–3 pm (Board No. B350) 1/3

Ok, I made a starter pack for membrane trafficking and organelles (broadly defined). Feel free to self-nominate! go.bsky.app/RbtJjt7

Looking for Cell Biologists to follow??
Check out these starter packs:
bsky.app/starter-pack...

@devdynamics.bsky.social Welcome to Bluesky Developmental Dynamics, added to the Developmental Biology starter pack II.

You can also patch in to more #DevBio folks by checking out the first Developmental Biology start pack here:

go.bsky.app/M5AgJhn

I laughed till I cried. I needed that!

Let your timeline shine with these outstanding #WomenInScience! 🧪 #zebrafish go.bsky.app/4BegEjv

Resharing this for those new to bluesky. If you are interested in #innateimmunity or #inflammation, here’s a starter pack or researchers to follow! Leave a comment if you wanna be added too. #immunosky #academicchatter
go.bsky.app/QqJ9AgB

Co-option of neck muscles supported the vertebrate water-to-land transition - Nature Communications The evolutionary water-to-land transition involved the separation of the skull from the pectoral girdle, though these musculoskeletal changes have not been deeply characterised. Here they show that th...

Where did our neck muscles come from?🧪
Here's our #evodevo #devbio deep dive feat. #zebrafish, mouse, axolotls, & more!

Led by Eglantine Heude & Tajbakhsh lab at Pasteur, the team at National Museum of Natural History France, & lab alumni Karin Prummel & Rob Lalonde.
www.nature.com/articles/s41...

Testosterone acts through the membrane protein GPRC6A to cause cardiac edema in zebrafish embryos Highlighted Article: A previously unreported non-genomic androgen signaling pathway in embryonic development is revealed by a chemical-genetic screen in zebrafish.

Zebrafish, CRISPR, and testosterone walk into a lab. The result? A new discovery about membrane/non-genomic androgen signaling and heart defects. 🐟💉 tinyurl.com/vvbezvkz 1/11

It's Giving Tuesday and I'm asking for donations to support the Angelman Syndrome Foundation. My daughter has Angelman Syndrome. She's an absolutely joy, but will require 24/7 care for life. We have a match to get us to $90K but we need your help! Please R/T!

www.angelman.org/giving-tuesd...

A brain microbiome in salmonids at homeostasis Salmonids have a resident bacterial community in the brain.

For those who want tp read the original paper, I forgot to share the link before www.science.org/doi/10.1126/...

Faculty Job Alert! #ScienceJobs
Michigan State University Integrative Biology is looking for a TT Assist Prof in Functional #Genomics. Join a vibrant research community for non-traditional #EvoDevo animal models! tinyurl.com/4hya8vet Deadline: 11/27/24 integrativebiology.natsci.msu.edu
Pls repost!