Sarah H. Shahmoradian

Sarah H. Shahmoradian

@shahmora.bsky.social

Assistant Professor, Center for Alzheimer's and Neurodegenerative Diseases at UT Southwestern. Our lab uses electrons to dissect molecular architecture in the brain. Engineering new tools for cryoEM in situ. ⚙️🧠❄️⚛️🔬 https://tinyurl.com/shahmoralab

41 Followers 28 Following 15 Posts Joined Jan 2025
3 months ago

Good luck on the experiments, and big congrats to Leo!!

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4 months ago
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An updated evolutionary classification of CRISPR–Cas systems including rare variants - Nature Microbiology An exploration of previously undescribed variants from the long tail of the CRISPR–Cas distribution.

#microsky #phagesky CRISPR-cas galore

www.nature.com/articles/s41...

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4 months ago
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Deep Learning for Microscopy Image Analysis Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,

Janelia is hosting a course on DL for bioimage analysis www.janelia.org/you-janelia/...

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4 months ago
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Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...

New paper in Science identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors!

www.science.org/doi/10.1126/...

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5 months ago

So well deserved! Proud to partner with you in this scientific journey and co-lead our amazing group of scientists. Super excited about what’s in store, and what is to come!

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5 months ago
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UT Southwestern researcher receives NIH Director’s New Innovator Award David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...

Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...

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9 months ago
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We have a preprint for you

EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer

By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...

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8 months ago
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Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ...
Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus
biorxiv.org/content/10.1...

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8 months ago

Congratulations! Best of luck!

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8 months ago
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To tilt or not to tilt? Strategies for in situ cryo-EM data collection Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…

Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...

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8 months ago

Very nicely written, and so timely!

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8 months ago

Brilliant!

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8 months ago
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🧑‍🔬📰🚀 #RxivMaker is here! A framework automating the creation of publication-ready scientific #preprints from simple Markdown. Goodbye manual formatting, and hello gorgeous manuscripts! A great adventure with @guijacquemet.bsky.social's lab

📜: zenodo.org/records/1575...
👨‍💻: github.com/HenriquesLab...

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8 months ago

Full video here, originally shared by DW. What Jeremy says is exactly right—clear, urgent, and deeply important. Cuts to science affect everyone, sooner or later, everywhere. Illness knows no ideology, no borders. This concerns us all. Watch, reflect, share, discuss.

bsky.app/profile/deni...

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9 months ago

What have we come to. And yet the additional detour is still infuriating. That drop. Maddening!

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10 months ago

Important question and timely piece. Scientists or not, we’ll all be affected. More people need to be aware of this vote, the timeline, and what’s really at stake!

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10 months ago

So much truth in this. Hear hear.

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10 months ago

Yes, yes, yes. This!

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10 months ago
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Scientists fear Trump administration cuts to NIH could impact the health of Americans for generations Former National Institutes of Health Director Dr. Francis Collins, who abruptly left his NIH research lab in February, fears aggressive downsizing could impact Americans' health.

Here is a link to 60 Minutes NIH segment...

www.cbsnews.com/news/scienti...

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10 months ago
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How cuts at the National Institutes of Health could impact Americans' health Cuts and layoffs to the National Institutes of Health threaten medical research around the U.S., agency insiders warn.

The National Institutes of Health, the largest funder of biomedical research in the world, has fired 1,300 employees and cancelled more than $2 billion in federal research grants. https://cbsn.ws/4daiCrv

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10 months ago

Chef's kiss. About damn time.

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10 months ago

Of course we've now moved on to cats 🤦🏻‍♀️

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11 months ago
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Bluetorial: Non-Competitive Renewal (Continuation) Awards

Normally, multiyear NIH grants are paid with awards each year, pending administratively reviewed progress reports. “NIH” has been slow in making these awards. This has led to $1.83 B being withheld from institutions through February 2025.

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11 months ago

They are going to make it harder for the scientists to stop, or even record, what comes next.

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1 year ago
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Walz: "The idea that the secretary of education would not know what IDEA is -- individuals with disability in education act -- that's like your mechanic not knowing how to put air in your tire. And she's in charge of this nation's education progress. It is catastrophic."

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1 year ago

Dear all, Because of your help shining light on this all 15 were reinstated today. This is a huge win for science - When We Fight We Win!!!

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1 year ago
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NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

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1 year ago
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Bluetorial: Women, courage, and leadership

What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.

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