Kevin C Klatt, PhD, RD

Holick and crew have been preaching very high for a while tho, mostly based on historical levels while living at the equator and old poorly controlled tx trials. I think most tend to argue for >30ng/mL. A few outcomes from some immune measures to cancer mortality have pointed towards higher than 30.

Investigation Update: Infant Botulism Outbreak, November 2025 Investigation details for an outbreak of infant botulism linked to infant formula, November 2025.

New CDC update on infant botulism - 2 new cases since Nov 8th, reported presence of bacteria in an open canister of ByHeart formula from California, and a re all of ByHeart Whole Nutrition Infant Formula for all lots.
share.google/FoBGPHIxF7Q5...

Heart attack risk halved in adults with heart disease taking tailored vitamin D doses Research Highlights: Adults with heart disease prescribed vitamin D in doses tailored to reach blood levels considered optimal for heart health (>40-80 ng/mL) had a reduced risk of heart attack by mor...

Glad to see more test-to-treat dosing trials happening for nutrients. Single dose vs placebo paradigms with no consideration of baseline and achieved levels have resulted in largely null but nearly uninterpretable results.
newsroom.heart.org/news/heart-a...

Nutrition isn't prescriptive - advice will always be a mix of evidence, philosophy, values, culture, economics etc. We already see so much nutr messaging that lacks applicability across cultures, economic status - all too often that same style appeals to nature & harms other areas of public health

Evidence-based health advice is a continuum of which nutrition is just a part of. Nutrition professionals have a responsibility to communicate is ways that are based on the evidence AND don't fuel fires that make communication harder for other areas of public health.

2009-2014 foodie tropes weve see rearing their heads as anti vaccine tropes since COVID

'if you can't pronounce it dont eat it'

'if your grandmother wouldnt recognize it don't put it in your body'

*Listing off ingredients scaremongering about their source and where else they are found*

Continuing to see so much blatantly anti-vaccine messaging nowadays that looks no different than foodie messaging (embraced by many legit folks) from a decade ago. If your nutrition messaging can be co-opted into an anti-vaccine tropes w minimal rewording, consider changing your nutrition messaging

Credit to MDPI for retracting this vitamin D/COVID-19 meta-analysis that @gidmk.bsky.social and I flagged: pubpeer.com/publications...

There are ongoing claims that acetaminophen (Tylenol) use in pregnancy causes autism. Here’s five things you should know 🧵

The admin is being quite explicit about this being a change in rec for farmer votes

content.govdelivery.com/accounts/USD...

This satfat focus centers noise and being anti-establishment - missing a huge opportunity to double down on refined carbs & the lack of long chain n3 Pufa intakes from fish.

There aren't blockbuster controlled trials with disease endpoints to support all of these conclusions so you can always play devils advocate (and many lucratively do)...but none of the available data points to Americans needing to eat more saturated fat.

This is why all major guidance emphasizes replacing saturated fat with mono- and poly-unsaturated fat sources and if there's a relevant option to substitute a satfat rich source with carbs, choosing fibrous ones appears best. The trial data and cohort align reasonably well on this.

most folks have replaced satfat intakes w high intakes of refined starches & sugars, themselves not great for several CVD risk factors. When folks advocate for eating more satfat saying it's 'healthy' they're almost certainly relying on comparisons of satfat vs refined carbs -a nutritional strawman

When you see high vs low satfat intake not associating w CVD, that could be bc there is no relationship,or it could be bc people eating low satfat eat more of something that is equally risky for CVD (thru ApoB or non-ApoB-mediated risk). The latter is what the thinking in the field is currently

The SatFat story is largely considered to be an issue of substitution - when you eat less satfat, what do you eat instead? Nutrition has no placebo and requires pairwise comparisons of all potential replacement sources of calories to rank nutrients/foods in relation to each other & disease risk.

SatFat-CVD is emblematic of the challenges of linking nutrition to chronic disease risk, casually. Dietary factors typically modestly influence chronic disease risk factors, which are themselves only partial determinants of chronic disease risk

The academic debates arnd saturated fat have largely questioned whether they're as 'bad' as once thought, given the limited association w CVD in cohort studies assessing self reported intakes in relation to risk (despite controlled feeding trials clearly showing a linear relationship w LDL/ApoB).

No, your protein powder isn’t poisoning you New testing finds two-thirds of popular protein powders exceed lead limits — especially plant-based brands. What you need to know before your next scoop — and why the reality is different.

You may have read that your protein supplements are giving you lead poisoning. That's not the case. If you want to have protein shakes, that's fine. But whether you need to and whether they're safely regulated is a different story. My latest for @vox.com.

www.vox.com/future-perfe...

Exclusive: Meet Richard Frye, who studies leucovorin for autism Frye has led two placebo-controlled trials of the folate supplement in autistic people; the first was suspended by regulators, and the other has yet to be published.

Meet Richard Frye, whose research record on leucovorin traces the gulf between promise and proof.

By Brendan Borrell

www.thetransmitter.org/spectrum/exc...

Folks following the leucovorin & autism story should be aware of a ton of PubPeer activity on one of the major trials. Many inconsistencies, statistical concerns, etc raised.
pubpeer.com/publications...

A good insider view of a dysfunctional FDA, helping to explain why Makary said leucovorin would treat 100Ks of kids w autism, meanwhile they pursued an indication for the rare disease of CFD.

FDA is choosing political wins at the expense of false hope for millions of families/ individuals w autism.

unbiasedscipod on Instagram: "The entire team that oversees NHANES mobile examination operations was RIFed. NHANES (National Health and Nutrition Examination Sur…" The entire team that oversees NHANES mobile examination operations was RIFed. NHANES (National Health and Nutrition Examination Survey) is our national program that sends mobile clinics across America to collect blood, urine, and health data from thousands of Americans each year. Unlike some other CDC cuts that have been reversed, this one hasn't - at least not yet. And there's no alternative plan in place.Without this team, the NHANES survey is unlikely to be able to continue. They don't just do planning for the next cycle (which their name might suggest) - they primarily conduct the day-to-day operations that keep the mobile units running.Why does this matter? NHANES is our only nationally representative source for:➡️Dietary intake data➡️Biomarkers of environmental toxins (pesticides, heavy metals, PFAS in blood/urine)➡️Population-level cardiovascular risk factors measured through actual blood work➡️Nutritional biomarkers (not self-reported)The data from NHANES is key for monitoring, surveillance, and discovery. It's how we know about diet quality & nutritional status, rates of obesity, and trends in blood glucose and cholesterol control. It's also how we monitor the prevalence of established and emerging toxins - everything from lead to PFAS. Continual collection of data is essential for tracking progress on public health goals, where we are falling short, and identifying the next link between exposures and health. Experts have readily called for an INVESTMENT in NHANES - so that we can sample broader populations, measure novel biomarkers & capture more environmental exposures. These cuts threaten the continuity of this key engine of public health, and we should all be concerned, regardless of party or politics.

If you're on IG, plz share this deck that me and a few other creators made last night breaking the story

www.instagram.com/p/DPxRPGADP3...

Workshop summary: building an NHANES for the future The American Society for Nutrition’s (ASN) Committee on Advocacy and Science Policy (CASP) organized a workshop, “Building a National Health and Nutrition Examination Survey (NHANES) for the Future,” ...

NHANES has been facing funding challenges and needs an infusion of cash to be modernized, not cut. These samples are a key dataset for the field of medicine, nutrition, metabolism, endocrinology, aging, etc.
So much innovation that could be brought to Nhanes!
ajcn.nutrition.org/article/S000...

Everyone across biomedicine should be very loud about this so this team's RIF status gets reversed. Nhanes has been key for tracking obesity & diabetes rates, identifying high blood lead levels in kids in the 70s, tracking progress on cholesterol lowering, guiding nutrient fortification programs etc

MMWR stole the show in the first round of headlines about CDC cuts but in the chaos, many missed that the NHANES mobile team remains RIF'd. This is the backbone of this key survey that contains some of the only representative anthropometric, biochemical, clinical and dietary data on the country.

This moment -- when we have a failing traditional healthcare system + increasing acceptance of low evidence, hyperbolic 'food is medicine'/lifestyle/functional medicine' + a government eager to co-opt/endorse wellness slop -- is particularly scary for folks who care abt evidence-based nutrition

BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:

Gave some quotes to NPR about the coming chaos with the DGAs.

Full primer here:
kcklatt.substack.com/p/what-to-ex...

Environmental Health Established in 2002, Environmental Health has an international readership and is rated in the top 25% of journals in this field. It covers primarily original ...

Peer Review reports went live on the 'Harvard' citation the administration is using to support the Tylenol-Autism/ADHD link. Pretty eyebrow raising

ehjournal.biomedcentral.com/articles/10....