SmithLabUMBC

Way to go!!

Improving Oversight of Federal Grantmaking By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal

Well, this is a huge Executive Order power grab...

www.whitehouse.gov/presidential...

1/3

😬

The 4th Annual Early Career Symposium at IBBR is Sept. 17th - Its a forum for graduate students & post-docs to share their scientific research in the fields of disease biology & biotherapeutics development & analysis - zurl.co/4oUyS We are sponsoring & exhibiting there

Drawn to the Light Emina Stojković from Northeastern Illinois University in Chicago on myxobacteria, maybe the most interesting microbes you’ve never heard…

Our July member tale is from Emina Stojković from Northeastern Illinois University in Chicago. Stojković is exploring new frontiers in photoreception & signaling while seeking new opportunities to advance the careers of her students after three NIH grant terminations.

More here:

Mmm. Metals.

Trump Administration Puts New Chokehold on Billions in Health-Research Funding The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.

NEW
The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year

Chokes off billions in research funding

Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social

How to express, purify and assess the activity of the ATE1 arginyltransferase | Methods in Enzymology | Yi Zhang lab @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...

Microbial metal physiology: ions to ecosystems Nature Reviews Microbiology - Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review,...

Metal ions are universally required for life, and many of the foundational principles of metal homeostasis have emerged from studies of microbial systems. In this review, I provide a introductory overview targeted to those new to the field.
#MicroSky #Metals

rdcu.be/eycU2

Congress eliminated public media funding, and the president signed it into law. At a time of deep division, public media brings us together.

Help keep it strong. Join our monthly donors today: n.pr/458sOhq

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Does anything from MR look even reasonable if you add, say, 4 molecules? We worked our way 4–>8–>12 with reasonable solutions (and clear diff density) each time along the way. We knew it was time to stop when going to 13 caused Phaser to take forever and then found no solution after 2 days running…

12 molecules of a 60 kDa protein in the ASU here (and at high symmetry…P4(3)!!). Big unit cell. Bootstrapped through MR with an initial AlphaFold model. It was…rough.

This will be wild (not really in a good way!) if it actually comes to fruition…

NIH will only accept six new, renewal, resubmission, or revision applications from an individual Principal Investigator/Program Director or Multiple Principal Investigator for all council rounds in a calendar year. grants.nih.gov/grants/guide....

More Life Science Grad Students To Be Prepared For Interdisciplinary Success Following Renewed NIH Funding For Chemistry Biology Interface Program - UMBC: University Of Maryland, Baltimore County Chemistry Biology Interface participants complete their degrees faster than students outside the program, and 97 percent graduate—well above the national average. The program is shaping Ph.D. students...

Recent coverage from UMBC news about the new incarnation of our Chemistry-Biology Interface (CBI) program. Happy that NIH is still supporting this program that is critical for biomedical graduate trainees at UMBC and UMB!

umbc.edu/stories/chem...

Copper acquisition in Bacillus subtilis involves Cu(II) exchange between YcnI and YcnJ The transition metal copper is biologically essential across all three domains of life. Several copper-dependent proteins and enzymes produced by the Gram-positive bacterium Bacillus subtilis have bee...

Copper acquisition in Bacillus subtilis involves Cu(II) exchange between YcnI and YcnJ

#JBiolChem from @fisherlab.bsky.social
with @johnhelmann.bsky.social

www.jbc.org/article/S002...

Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins - Nature Communications Many pathogens encode transporters that extract heme directly from host proteins. In this study, the authors demonstrate the utility of de novo-designed proteins in understanding the mechanism behind ...

Excited to share our latest work using AI-designed proteins to block heme-piracy by E. coli. Published in @natcomms.nature.com. A team effort between my lab and the ‪‪@knottrna.bsky.social‬ ‬lab, with experimental work led by the talented @danielrfox.bsky.social
www.nature.com/articles/s41...

That you have faculty meeting in the summer is 😱🫠

DEGRONOPEDIA - a web server for identifying and predicting protein degradation signals across eukaryotic proteomes. Detailed guide by Natalia Szulc @lumirare.com and Wojciech Pokrzywa @wpokrzywa.bsky.social in Methods in Enzymology. @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...

How to detect protein N-terminal arginylation - a key step of protein degradation via the Arg/N-degron pathway. By Jasper Eising and @ndissmeyer.bsky.social in Methods in Enzymology. @ispt-proteinterm.bsky.social www.sciencedirect.com/science/arti...

Oh! Ooooh...?! Oh no.

Can also confirm Bergen, Oslo, and Stockholm airports over the last week!

America has no king, so isn’t everyday No Kings Day?? 😁

Fantastic news!!

Student-led experimental evolution reveals novel biofilm regulatory networks underlying adaptations to multiple niches We established a research-education partnership known as EvolvingSTEM that provides secondary school students the opportunity to conduct authentic research experiments centered on microbial evolution....

Sharing the most significant work from my group, led by the @evolvingstem.bsky.social team.

Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵

www.biorxiv.org/content/10.1...

Sidewalk with “rainbow rage” written in rainbow colors in chalk

Daily dose of 🌈, neighborhood Pride Crawl edition.

Thank you! I hope this means many other programs are (finally) getting their NOAs, too!

With all the craziness that's been happening, I am pleased to announce that our new UMBC-UMB Chemistry-Biology Interface (CBI) T32 was awarded today by NIGMS for five years! I know we've been disheartened to see the "T32 flat line" for new grants, but I am happy this bumps it up...a bit...