🚨 Our new paper is out! 🙌
Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs.
We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs.
www.cell.com/chem/fulltex...
1/4
Kids: “Dad that car cut you off!”
Me: “He’s harmless.”
Were they told they had to drink it before passing through
We are hiring a postdoc! The group has a funded opening to join our amazing team on the NCI's Frederick, MD campus.
This is an opportunity to train in cutting-edge chemical & RNA biology methods with a supportive, tight-knit group.
Link to posting below. Please share!
jobrxiv.org/job/national...
This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...
douglas adams was our most accurate futurist
If it were 2026 he would say: "species and varieties of Seq experiments."
Happy birthday to one of my favourite haters, Charles Darwin
3️⃣4️⃣ Robert G. Roeder collecting sea urchings, the organism in which eukaryotic RNA Pols I, II and III were discovered
(source : youtu.be/efNtZyXSHC4?...)
😂
"There’s never been a better time to touch the hearts of people, you just have to be human." A wonderful post on my Substack by Freya India, one of the best writers I know, who writes about Gen Z.
www.afterbabel.com/p/you-have-t...
"authors also express frustration at the amount of work expected for a single publishable unit, a concern we
share (while humbly noting that it may not be
held by the same authors when they serve as
reviewers of other work)" <-THAT www.nature.com/articles/s41... ht @ritastrack.bsky.social
Biochemist/molecular biologist Joan Steitz was born #OTD in 1941.
She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
I’ve seen some weird drug molecules over the last 30 years but not many that I’d use as a synthetic intermediate (and store in a sealed vial) #ChemSky #ChemChat
(h/t @drughunter.com for the screenshot)
I was late to this just coming out but the crazy idea here is to store transcriptome in Vault particles as a snapshot of the prior gene expression states!!!
this is a fascinating article, featuring a ton of analytical chemists arguing with one another #chemchat
Excited to share our new preprint in collaboration with Paul Cohen's lab at Rockefeller University and Ken Loh's lab at Yale University! We introduce TurboID-TMT for cell type-specific proximity labeling to profile organ secretomes and ER-resident proteomes in vivo. www.biorxiv.org/content/10.6...
Greetings! I decided to make a YouTube video of my AlphaFold workshop that I've given a few times in the past year. Caveats aside, people seem to find this useful for thinking about how to model protein interactions and how to interpret various AF outputs 1/2
www.youtube.com/watch?v=u63o...
Magic Johnson was the grand marshal of the Rose Parade today, and as someone who remembers his November 1991 HIV announcement: if you had told anybody that day that he would be alive and healthy 34+ years later, I don't think they would have believed you. Medicine and research—they work.
New post!
There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost.
Medical breakthroughs in 2025. Plus a serious note at the end.
www.scientificdiscovery.dev/p/medical-br...
What Do Oral Drugs Really Look Like? Dose Regimen, Pharmacokinetics, and Safety of Recently Approved Small-Molecule Oral Drugs
Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏
www.biorxiv.org/content/10.6...
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender: Cell Metabolism www.cell.com/cell-metabol...
My wife, who designed our card, completely shares my sense of humor. Happy holidays!
It’s the most wonderful time of the year…
Is this a commentary on the job market
😬
This “major update to ProteomicsDB” is definitely worth a look. academic.oup.com/nar/advance-...
Tubular.
