Jordan Meier

Also Coach, referee, concessionaire, photographer, fundraiser, events manager…but spectator is nice!!

It is such a privilege to be a spectator at the Olympics of Growing Up.

Silencing mitochondrial gene expression in living cells Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central mechanis...

Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...

Amazon review of Pride and Prejudice, left by carlton p morgan on 30 July 2010: "Just a bunch of people going to each other's houses"

Happy 15th anniversary of the peak achievement of literary criticism, to all who celebrate

An excellent systematic analysis of RBPs by @quaidmorris.bsky.social and colleagues (with a tiny contribution from us) #RNAsky #RNAbiology

I think maybe I’ve been overcompensating with my Spotify 😆

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa 🦠👏High-throughput tRNA epitranscriptome profiling using mass spec on P. aeruginosa transposon insertion library and links with metabolic networks #microsky #rnasky doi.org/10.1093/nar/...

Starbucks moving into the $6 lemonade game was a genius move (guilty 🤚)

Wonderful thread 👇

If you are interested in peptide-based protein binders, check out this new @biorxivpreprint.bsky.social by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social on their computer-based design.

Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?

www.biorxiv.org/content/10.1...

Multiplexed assays of variant effect for clinical variant interpretation Nature Reviews Genetics - Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et...

Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU

🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk

Paper in Nature 150 years ago. Beats reading any single-cell experiment…

Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

AMPLIFY

bsky.app/profile/doc-...

@aledmedwards.bsky.social I’d like your thoughts.

First to degrade BRD4 in space wins

Preprint: “Structural modeling reveals viral proteins that manipulate host immune signaling”

Using AI-guided structural modeling, we find new families of viral proteins that sequester or cleave host immune signaling molecules

Congrats Nitzan Tal!

www.biorxiv.org/content/10.1...

Sometimes it’s the little things that make your day 😊

IT USED TO BE LIKE THIS A LOT MORE

New paper:
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.

www.biorxiv.org/content/10.1...

A Brief History of GFP Podcast Episode · Asimov Press · 04/28/2025 · 30m

Road trip listening enjoying @asimovpress.bsky.social pods with the fam including this one featuring the late great RJT

podcasts.apple.com/us/podcast/a...

Had to make a road trip pit stop to honor Cornell’s most famous chemistry major. Hitting different this year. So it goes.

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!

tinyurl.com/ydn6e3ac

Written before your lecture. You delivered!

Alphagenome is out

storage.googleapis.com/deepmind-med...

Who wrote this comment @dannomura.bsky.social

How does nobody have SD??
TSRI, UCSD, Salk, Burnham, La Jolla Institite for Immunology, pick 3