Jordan Meier

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Huang et al. show that excessive vigorous exercise causes cognitive impairment. During this process, muscle lactate accumulation facilitates the secretion of otMDVs through ATF5 lactylation. PAF and m...

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender: Cell Metabolism www.cell.com/cell-metabol...

My wife, who designed our card, completely shares my sense of humor. Happy holidays!

old tweet: Every year, Putting Away the Christmas Decorations Ken makes a series of decisions designed to infuriate Unpacking the Christmas Decorations Ken the following year. It’s a magical holiday tradition.

It’s the most wonderful time of the year…

Is this a commentary on the job market

😬

Mapping drug mechanisms with ProteomicsDB: unified omics and cell sensitivity data at scale Abstract. Proteomic and phenotypic cell sensitivity datasets are increasingly important for understanding chemoproteomics and the underlying drug mechanism

This “major update to ProteomicsDB” is definitely worth a look. academic.oup.com/nar/advance-...

Tubular.

Pilot just came on and said that in addition to turbulence, “We are flying today with an unusually large number of tubes. Please make sure you exit the plane with the correct tube.” Non #SFN25 passengers very confused 😂

Uche Medoh

For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.

🎉 Learn more about the work: https://scim.ag/4qVpK1a

Current group mood 🚀 🚀

That’s high praise!

a close up of a woman 's face with a piercing in her nose ALT: a close up of a woman 's face with a piercing in her nose

Every time I open a Capri Sun:

Reading this, it truly resonates how fortunate we were that Jim Watson never took an interest in social media.

Huge congratulations to @craigmcrews.bsky.social on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery.
#ChemSky #ChemBio #TPD

There was an epilogue written in the Eighth Day of Creation about 30 years ago that also covers this in detail...

Screenshot of a Tweet pointing out that academic spam is actually in its own way kind of encouraging.

I think about this post every day 🧪

Looking forward to publishing industry rebranding as anti-AI, anti-bot safe haven (not because they care about quality, but because it’s the last defensible market position)

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

Wonderful to see discoveries converge. Congrats to all the teams!!

Beautiful discovery by the Huber and Kubicek labs and a wonderful example of using targeted protein degradation to probe novel non-catalytic functions.

Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants https://www.biorxiv.org/content/10.1101/2025.11.04.686643v1

Flying Squirrel Loves It Every Time

Flying Squirrel Loves It Every Time

Small molecule targeting of transcription-replication conflict for selective chemotherapy Gu et al. used crystallography-directed medicinal chemistry to identify a small molecule ligand of PCNA that interferes with the resolution of transcription-replication conflicts. This compound was fo...

This account has a history of hype. A few years ago I remember a similar post about this molecule:

www.cell.com/cell-chemica...

These approaches have potential, but it is early days for each.

Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?

rdcu.be/eN1jm

Required reading for cell biologists to get a sense of basic statistical principles!

www.nature.com/articles/s41...

It makes me chuckle every time I see it. Highly recommended!

Every scientist’s secret aspiration is to make it into this Pubmed alert:

If you’re the parent of two trick-or-treaters who want to trade candy, it’s your job to act as commissioner to oversee any trades to avoid any Nico Harrison situations.

Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime

www.youtube.com/watch?v=tdNn...