Tyler Ekins

Millisecond spiking units in dispersed mycelial liquid culture MEA recordings absent in dehydration and fungicidal assays The extracellular electrophysiology of dispersed mycelial liquid cultures has not previously been investigated in terms of wide bandwidth frequency components and presence of putative spiking units. H...

Earl, do you have any thoughts on spike-like activity but seeming lack (?) of lfp in mycelial networks? e.g. www.biorxiv.org/content/10.1...

Thank you!

Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors - Molecular Psychiatry Molecular Psychiatry - Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

Excited to share our latest publication -- psychedelic drugs can enhance synaptic connectivity of neurons not expressing 5-HT2ARs (but requiring 5-HT2AR expression in the input neurons -- lots in the supplementals too!)

www.nature.com/articles/s41...

Got mine too -- thank you @cllantz.bsky.social !

Much better 🤨

Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration Psychedelic compounds have demonstrated remarkable therapeutic potential for treating neuropsychiatric disorders by promoting sustained neuroplasticity in the prefrontal cortex (PFC). Cognitive flexib...

Our latest manuscript (from www.omarlab.org) is now published and available online --
Long lasting enhancement in reversal learning after a single psychedelic dose

pmc.ncbi.nlm.nih.gov/articles/PMC...

Set a rainbow swirl cold process soap on a railing

A blue gloved hand holding a rainbow swirl bar of cold process soap.

Did you go to #GRCpsychedelics and not get soap? Don't worry, our themed soap will be ready in 2-3 weeks. Mouse brain toppers, rainbow swirl, dendrite+spine embed. Happy to send a free bar to ~10 people/ attendees.

These are handmade by an amateur, so expect imperfections.

Thank you so much!!

Incredible! If any are still available i would
love one too!

Somehow we got almost all the students and postdocs in one photo!!

Until next time #GRCPsychedelics 🫡

#GRCPsychedelics is squad goals !!

I learned so much, laughed even more, and slept even less

Grateful for the new connections, strengthening of old ones and for the opportunity to view my favorite topics from a different lens.

A starter pack including all attendees (that I can find for now)

Please let me know if I missed anyone!

#GRCPsychedelics

go.bsky.app/2ExXJcr

Also interesting that insula is loaded with Htr2a!

An AI generated image of a psychedelic slack discussion group

Awhile back we started a Slack group for psychedelic science.

Researchers used it to organize meetups and panels at conferences. We discuss papers, including a lively discussion now of the Lu et al. preprint.

DM @mikaelpalner.bsky.social or I if you work in academia and want to join

Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪

Led by Ling-Xiao Shao and @ItsClaraLiao

Funded by @NIH @NIMHgov

📄 Read in @nature.com - www.nature.com/articles/s41...

1/12

Congratulations!

not quite the same!

nice! looking forward to reading this

Psychedelic enhancement of flexible learning weeks after a single dose Psychedelic drugs have shown therapeutic potential for the treatment of multiple neuropsychiatric disorders chiefly by promoting long-lasting plasticity in the prefrontal cortex (PFC). A critical func...

Our latest preprint -- a single psychedelic dose induces a long-lasting improvement in reversal learning ability

www.biorxiv.org/content/10.1...

Schematic of the experiment

Our latest work led by @claraliao.bsky.social is a collaboration with the other Kwan lab @kwanlab.bsky.social

We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬

www.biorxiv.org/content/10.1...

many books!

really interesting paper!

Psilocybin slows and reduces complexity of neural dynamics in medial prefrontal cortex.

New paper with Ross Purple, Rahul Gupta, Matt Jones & Co.

Mathematica A fascinating look into how the transformative joys of mathematical experience are available to everyone, not just specialists   Math has a reputation for ...

Mathematica, A Secret World of Intuition and Curiosity
yalebooks.yale.edu/book/9780300...

and

Poisoner in Chief
us.macmillan.com/books/978125...

Short- and long-term reconfiguration of rat prefrontal cortical networks following single doses of psilocybin https://www.biorxiv.org/content/10.1101/2024.12.10.627734v1

Great work!

I read this in grad school and absolutely loved it (at least books 1 and 2)!

I patch a lot of cells!

Cellular rules underlying psychedelic control of prefrontal pyramidal neurons Classical psychedelic drugs are thought to increase excitability of pyramidal cells in prefrontal cortex via activation of serotonin 2A receptors (5-HT2ARs). Here, we instead find that multiple classe...

Our preprint on psychedelic control of prefrontal cortex pyramidal neurons! (from www.omarlab.org)

www.biorxiv.org/content/10.1...

I study cellular and systems effects of psychedelics at University of Michigan!