Dr Will Unsworth

‘Clip-Cycle’ approaches to functionalised pyrrolidines, pyrrolizidines and indolizidines The ‘Clip-Cycle’ approach is a versatile and modular synthetic method for the synthesis of aza-heterocycles via sequential cross metathesis and aza-Michael reactions. In this manuscript, a series of…

🔓Read a #OpenAccess paper in our latest issue by @prof-ian-fairlamb.bsky.social, @unsworthchem.bsky.social & co. @york.ac.uk reporting innovations to the ‘Clip-Cycle’ approach for functionalised pyrrolidines, pyrrolizidines and indolizidines #orgchem

Find it in full🔽

So pleased to share this work on alkaloid biosynthesis.
Great collaboration with @unsworthchem.bsky.social. Well done to all authors. We have found key alkaloid producing enzymes that look like those normally found in bacteria.

www.york.ac.uk/news-and-eve...

New paper out today on alkaloid (bio)synthesis with @unsworthchem.bsky.social . Dr Lachlan Waddell made ten bioactive securinine alkaloids using "biomimetic" total synthesis - a strategy that we think is analogous to the plant makes the alkaloids by biosynthesis. pubs.rsc.org/en/content/a...

Cyclopropanation reactions by a class I unspecific peroxygenase Non-natural biotransformations, such as alkene cyclopropanation through carbene insertion, have been demonstrated for the hemoproteins cytochrome P450 and myoglobin, but have not been investigated…

🔓Check out this #OpenAccess research by @unsworthchem.bsky.social ,Gideon Grogan & co @york.ac.uk in our latest issue describing cyclopropanation reactions by a class I unspecific peroxygenase #orgchem

Read it in full below👇
pubs.rsc.org/en/content/a...

Assuming you mean the Man City game, fans likely to be leaving from 1930. Could be later if it goes to extra time, but I doubt it will. For what it's worth, seems unlikely to be a game with l a lot of trouble afterwards based in the teams involved.

Clearing out my office and came across this much reused folder. You can just make out a scribbled date, 29 Jan 87, for a tutorial with Bruce Gilbert. So it's at least 38 yrs old. Channeling my inner womble, I think I'll keep it a little longer. @professor-dave.bsky.social @unsworthchem.bsky.social

Whoops - thanks!

The ideas behind this paper all came from the Gregynog Synthesis workshop - ALL participants of the 2022 edition of this legendary meeting are duly acknowledged!

Very happy to announce our latest paper - out today in Chemical Science

A very enjoyable collaboration with @roly armRoly Armstrong
on Stereoselective Synthesis of Atropisomeric Amides.

doi.org/10.1039/D4SC05

🚨Funded PhDs available 🚨
2nd hiring round of the York-Oxford CDT in sustainable synthesis is open.
Seeking a talented organic chemist to work with me, Gideon Grogan and Ed Anderson on a synthesis project using enzymes (#28). Inquiries welcome!
cshp-cdt.chem.ox.ac.uk

Port Charlotte great too!

Thanks Tom - pretty sure I've never tried any Glenallachie. Will keep in mind. Although I tend to favour very smokey/peaty. Can't go wrong with a Bowmore of the others you have.

Dehydrogenative Photoredox Catalyzed Synthesis of Indolyl Δ2‐Isoxazolines via a Formal C(sp3)–H Functionalization. A dehydrogenative photoredox catalyzed formal C(sp3)-H intramolecular cyclization of indolyl-oximes to generate indolyl Δ2-isoxazolines is reported. In contrast to the current state-of-the-art, the r...

And the second, Dehydrogenative Photoredox Catalyzed Synthesis of Indolyl Δ2-Isoxazolines via a Formal C(sp3)–H Functionalization. With the equally amazing Wade Petersen.

doi.org/10.1002/ejoc...

Divergent Oxidation Reactions of E‐ and Z‐Allylic Primary Alcohols by an Unspecific Peroxygenase Unspecific Peroxygenases (UPOs) catalyze the selective oxygenation of organic substrates using only hydrogen peroxide as the external oxidant. The PaDa-I variant of the UPO from Agrocybe aegerita cat...

Very happy to announced 2 new papers from the group in the last 24 hours!

The first, Divergent Oxidation Reactions of E- and Z-Allylic Primary Alcohols by an Unspecific Peroxygenases, just out, with my amazing collaborator Prof Gideon Grogan

onlinelibrary.wiley.com/doi/10.1002/...

I usually have a Laphroig on the go but not currently - will need to rectify!

Definitely a great selection. Most not mine I should say - my mate hosting has a collection of several hundred! The Tullibardine my favourite of the night.

Whisky night!

Thanks a lot for the shout out Scott, and thanks Derek for helping to showcase the power of ring expansion methods to make tricky larger ring sizes. Plus, who doesn't love a nice rearrangement reaction!

Cyclic amine ring expansion Nature Chemistry - Aza-heterocycles with rings of more than 6 members are underrepresented in medicinal chemistry owing to challenges with their synthesis. Now, the conversion of 5- and 6-membered...

Happy to share our News and Views article on a very cool new ring expansion approached developed by Yifeng Chen and coworkers.

Written with Jack Wootton, and just out in Nature Chemistry

rdcu.be/d0ZAe

See you tomorrow Kevin!

Second post - major congratulations to Barbara Radzikowska for passing her viva.👩‍🎓 Thank you to examiners Dr Lianne Willems and Prof Chris Willis. Cosupervised by @unsworthchem.bsky.social . Seriously impressive project on complex alkaloid biosynthesis in Daphniphyllum. 🥳

Delighted to announce publication of the 2nd posthumous paper from the lab of our friend and colleague Prof Paul Clarke.

With Saikiran Ravi, Chris Maddocks and Prof Ian Fairlamb

We all miss you Paul – hope we have done the work justice

pubs.rsc.org/en/Content/A...

A Modular Strategy for the Synthesis of Macrocycles and Medium-Sized Rings via Cyclization/Ring Expansion Cascade Reactions Macrocycles and medium-sized rings are important in many scientific fields and technologies but are hard to make using current methods, especially on a large scale. Outlined herein is a strategy by wh...

Need something for my first post over here, so gone for a shameless plug of our JACS paper published earlier this year!

Looking forward to interacting with you all again in a better and less angry place.

pubs.acs.org/doi/10.1021/...