simon saubern 🌀

ChEMBL 36 is out! 📊 Database Scale 🆕 New Data Sources Src_ID 72 – Chemical Probe data from Scientific Literature NLP and manual extraction from probe-r...

ChEMBL 36 is out!

chembl.blogspot.com/2025/09/chem...

Anionic Reversible Addition–Fragmentation Chain-Transfer Polymerization of Methacrylates Anionic polymerizations of methacrylates are controlled processes that give well-defined materials; however, these polymerizations require reactive and pyrophoric organolithium reagents for initiation...

💯💯💯 100th paper alert!!! 5th year @paigejacky.bsky.social and 3rd year Madison Neukirch have achieved RAFT for anionic polymerization using an aldehyde CTA! What some professors have called "sh*tty aldol chemistry," we call success 😎 doi.org/10.1021/jacs...

SciFinder result describing continuous flow pancake maker.

🤨 I think I'm starting to see a pattern in my SciFinder updates: 🥞

#sighfinder

#flowchemistry #chemsky

#chemsky #flowchemistry

Applications of Fluidized Bed Reactors in Biocatalysis The fluidized bed reactor combines the properties of a stirred tank reactor and a continuous tubular reactor. Its advantages are its high transfer capacity and its use with liquid and gas phases. Thi...

Happy to share our latest review 👇

#biocatalysis
#flowbiocatalysis
#flowchemistry

Applications of Fluidized Bed Reactors in Biocatalysis - Guajardo - ChemBioChem - Wiley Online Library chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

#flowchemistry

Coffee themed chess set seen through window of a cafe.

You know you have a coffee obsession when...

In KNIME Analytics Platform 5.5, you can now reorder your workflow tabs, making it easier to stay organized while working across projects. 📂

This update was developed based on user feedback. 💬

Explore what else is new in KNIME Analytics Platform 5.5: knime.com/blog/whats-n...

#flowchemistry

#flowchemistry

Streamlining Vorinostat Synthesis: A Chemoenzymatic Continuous Flow Approach A chemoenzymatic protocol for the synthesis of histone deacetylase inhibitor vorinostat has been established. Immobilized lipase from C. antarctica (imm-CaLB) allowed the functionalization of suberan...

#flowchemistry

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

OpenAI just updated ChatGPT to be able to use RDKit, a cheminformatics Python package.

OpenAI's president says this makes ChatGPT "useful for scientific work across health, biology, and chemistry," but it is hilariously still not good at chemistry (🧵)

#chemsky #AI ⚗️🧪🖥️

with = width 😒

Image shows a long chemical name wrapped to fit its narrow column.

TIL there's a #KNIME node to wrap strings to fit the column with when viewing a table, instead of truncating the string.

hub.knime.com/n/cr_B5IrwLl...

#chemsky

'Go' With The Flow' 2025 poster in English. Abstract submission deadline 12th May, General Registration deadline 26th May.

'Go' With The Flow' 2025 poster in Welsh. Abstract submission deadline 12th May, General Registration deadline 26th May.

I am proud to announce the second annual ‘Go With The Flow’ conference for 2025.
The conference will take place on June 9th.
This year our plenary speakers are Professor Tim Noёl, @tnoel82.bsky.social, Professor Stephen Hilton, and Dr Charlotte Willans.

See the poster for details:
🧪 #flowchemistry

#flowchem

Scifinder search for flow chemistry found a patent for production of noodles.

Damn it. Now I'm hungry. 🍜
#sighfinder #flowchemistry

Pile of chillies at the market

Chilli season!

There was an update a while back that let's you turn off Text-to-Date conversions:

bsky.app/profile/saub...

#chemsky

Flow Chemistry for Flowing Cross-Couplings: A Concise Overview Cross-coupling reactions have revolutionized synthetic chemistry by significantly expanding the scope of carbon–carbon (C–C) and carbon–heteroatom bond formation, making them invaluable tools in the d...

Review on cross-coupling reactions using #flowchemistry from Brindisi's lab.

Suzuki, Heck, Sonogashira, Negishi, Stille, Buchwald

doi.org/10.1021/acs....

#chemsky

‎SciKey - Scientific Keyboard ‎SciKey is a Scientific Keyboard that brings you the essential scientific characters for your iPad, iPhone, and iPod touch. Fully customizable, with more than 3,000 characters to choose from, to buil...

SciKey can get you started, or search for “scientific keyboards” for other apps: O₃
apps.apple.com/au/app/scike...

New hydrogen and helium discovery opens doors to clean energy potential - Australian Manufacturing A recent report from Geoscience Australia and the Geological Survey of New South Wales has uncovered elevated levels of natural hydrogen and helium in various regions across New South Wales, paving th...

New hydrogen and helium discovery opens doors to clean energy potential, Australian Manufacturing www.australianmanufacturing.com.au/new-hydrogen... #NMRchat #NMR 🧲🎈

Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source Photochemical transformations have garnered renewed interest over the past decade for their ability to enable unique reactions under mild conditions. However, scaling up such processes, particularly in multiphase systems (e.g., gas–liquid), remains challenging. Previously, we demonstrated the potential of the photochemical rotor-stator spinning disc reactor (pRS-SDR) for scaling the photooxidation of α-terpinene to ascaridole, though the system was limited by the light source, resulting in suboptimal operation in a photon-limited regime. In this work, we unlock the full potential of the pRS-SDR by integrating a high-powered light source (up to 652 W optical output) specifically designed for the reactor. The results show that the high gas–liquid mass transfer rates achievable in the pRS-SDR allow for significant productivity improvements under high irradiance (16.3 kg day–1 at 92% α-terpinene conversion and 2.52 W cm–2 in a 27 mL irradiated volume), representing an order of magnitude increase compared to our previous study. However, the photooxidation of β-citronellol exhibited notable limitations, highlighting the importance of selecting appropriate model reactions when evaluating intensified photochemical reactors.

Paper 2 of 2025 is also an engineering one: scaling up photochemical reactions to >15kg/day is possible with our continuous-flow spinning disk reactor equipped with a high-intensity LED.

🔗OPRD: pubs.acs.org/doi/10.1021/...

@achaudhuri.bsky.social, @jhaschuurmans.bsky.social, @tnoel82.bsky.social

#ozchem

Can membrane aging be improved by using higher flow rates? I was taught to use these for polymer diafiltration by protein chemists, who explained fouling is reduced by keeping the tangential flow high >10ml/min.

Really excited to see our #3dprinted reactors designed to work with the @IKAworldwide IKAFLOW being printed with a new polymer from flxr.engineering - some great work coming soon in the New year! With @ucllifesciences.bsky.social

#flowchemistry

#flowchemistry

#flowchemistry