Dr. Paula Littlejohn, PhD, MHS

In World IBD Day, highlighting some of my recent work in advancing research on IBD. #nutrition #IBD

Frontiers | Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model

Very grateful to be a part in this project now finally published. www.frontiersin.org/journals/imm...

Standing together with IBD patients, their families and caregivers across the globe to find better biomarkers, treatments and ultimately a cure.

Sometimes being an enigma can be your superpower—life lessons

As always, @nature.com hits the mark with timely, appropriate commentary that speaks to deeper issues. I really enjoyed this article as I begin to find ways to engage with communities my research aims to help.

#IinternationalWomensDay

Science is still relevant, and so are women and girls in science. #internationaldayofwomenandgirlsinscience

Wow, I’ve been thinking this is what’s happening in the U.S. to hear someone who’s lived through one confirm it is a bit sobering. I also do research in Canada but grew up in the U.S., it’s sad to watch.

Delighted to be a panelist at the Soroptimist Surrey/Delta/White Rock Dream It, Be It conference. My take home messages: bring your creativity, learn to listen more in a world that is often so loud, practice critical thinking and show up as your authentic self to Dream It and Be It.

I think it will take some time. I think some people are a little battle fatigued and just need a space that’s quiet for a sec. There’s a lot going on. But we’re with you.

Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma Progression This study develops engineered glioblastoma organoids to investigate the role of specific mutations in tumor progression. The analytic framework spans single-cell analysis, spatial transcriptomics, s...

New Millman lab publication out in Advanced Science using genetically engineered brain organoids to model glioblastoma (GBM). Excited to collaborate with Albert Kim
to extend our stem cell expertise to cancer. Congrats 1st author Matt Ishahak advanced.onlinelibrary.wiley.com/doi/10.1002/...

Kudos 👏🏾👏🏾👏🏾

This figure illustrates molecules and minerals discovered in samples of near-Earth asteroid Bennu, which were delivered to Earth by NASA’s OSIRIS-REx mission in September 2023. The upper left panel depicts precursor molecules like ammonia and formaldehyde, while the upper right depicts salts and clays. These early ingredients mixed with water inside the parent body to undergo chemical reactions and synthesize organic molecules, shown at bottom. The lower right panel depicts nucleobases, the genetic components of DNA and RNA, while the lower left depicts amino acids, the building blocks of proteins. The Bennu samples contain all five of the nucleobases that are found in DNA and RNA, and 14 of the 20 amino acids that life uses to build proteins. Credit: NASA

Rock and dust samples brought back from the near-Earth asteroid Bennu contain organic matter, including amino acids and all five DNA and RNA nucleobases, according to two papers in Nature Astronomy and Nature.
https://go.nature.com/40SlwfF
https://go.nature.com/3CC6ZLO
🔭 🧪

Researcher in pediatric IBD studying nutritional deficiencies, wound healing and epigenetics.

Will do, thanks

Nutritional deficiencies and associated pathologies present unique challenges of diagnosing paediatric inflammatory bowel disease in sub-Saharan Africa Inflammatory bowel disease (IBD) represents two idiopathic conditions (Crohn’s and ulcerative colitis (UC)) of chronic inflammation of the gastrointestinal tract affecting all ages with no known cure....

Nutritional deficiencies are a common complication of IBD. In this Editorial we discuss the challenges of diagnosing and managing IBD in sub-Saharan Africa where underlying nutritional deficiency is endemic. nutrition.bmj.com/content/earl...