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Diana Giron

@dianagironce.bsky.social

Experimental Medicine PhD Student at University of British Columbia and BCCHR | Studying #immunology #organoids #IBD & #microbes

135 Followers  |  142 Following  |  1 Posts  |  Joined: 22.03.2024  |  1.5745

Latest posts by dianagironce.bsky.social on Bluesky

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How much does your gut health impact your overall health? A lot, doctors say | CBC News Doctors are tapping into to the emerging field of the gut microbiome to try to treat some diseases differently.

🚨 We’re featured in @CBCNews!
Our team is using organoids to study how microbes interact with the gut mucus layer, and how this relationship impacts diseases like IBD πŸ’©πŸ”¬
πŸ“° Read the full story: www.cbc.ca/news/health/...
#Microbiome #GutHealth #Organoids #IBD

02.06.2025 22:10 β€” πŸ‘ 12    πŸ” 9    πŸ’¬ 1    πŸ“Œ 0
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Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined. F...

New paper from our lab! We developed an organoid-based air-liquid interface (ALI) model that produces physiologically relevant intestinal mucus and discovered that EspC has a mucinolytic superpower which enables C. rodentium to degrade mucus. 🧫🦠https://pmc.ncbi.nlm.nih.gov/articles/PMC12054374/

08.05.2025 23:45 β€” πŸ‘ 6    πŸ” 4    πŸ’¬ 2    πŸ“Œ 1
JCI Insight - MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease

πŸŽ„ Santa came early this year!πŸŽ„

We’re unwrapping an exciting discovery from our lab that reveals the critical role of the transmembrane mucin MUC17 in protecting the small intestine against bacterial challenges.

insight.jci.org/articles/vie...

#mucins #glycotime #Crohns #gut

22.12.2024 11:43 β€” πŸ‘ 16    πŸ” 5    πŸ’¬ 8    πŸ“Œ 0
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IFN-Ξ³-dependent regulation of intestinal epithelial homeostasis by NKT cells The crosstalk between immune and epithelial cells is vital to maintain intestinal homeostasis. Lebrusant-Fernandez etΒ al. identify NKT cells in the small intestine as key regulators of epithelial biol...

Our first πŸ¦‹ post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out!
@vivianlilab.bsky.social @kingscollegelondon.bsky.social

www.cell.com/cell-reports...

24.11.2024 11:00 β€” πŸ‘ 203    πŸ” 57    πŸ’¬ 5    πŸ“Œ 6

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05.12.2024 06:10 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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