Bérénice A. Benayoun, PhD

Single-cell exploration of ovarian aging across vertebrate models Mammalian female reproductive span is thought to be limited by a fixed "ovarian reserve" determined at birth. With age, a dwindling ovarian reserve leads to infertility, culminating in menopause in hu...

We are grateful for funding from the @cziscience.bsky.social data insights program for supporting this study, which we hope will be useful for the field!
#ovarian #singlecell #genomics #aging
Find the preprint at www.biorxiv.org/content/10.1...

Minhoo also leveraged #ASGARD to identify potential drugs that could revert transcriptional aging signatures across cell types and across species, yielding candidate conserved anti-ovarian aging compounds which will deserve further investigation. 5/5

Granulosa and Theca cells, major somatic cell types of ovarian follicles, showed clear changes with aging, with some species-specific gene regulation, but also conserved changes. Importantly, expression of FSHR and OSGIN2 was consistently decreased across datasets and models. 4/5

Datasets were processed with a unified standardized pipeline for easy #integration and #comparison. This included analysis of cell proportion changes, differential gene expression, and potential drug repurposing targets. 3/5

Study sample description

Minhoo identified a number of high-quality #ovarian aging datasets across mammalian species, spanning humans🚶‍♀️, monkeys🐒, mice 🐁, and goat🐐, with samples across the reproductive lifespan. We reasoned this would allow us to identify conserved signatures of #ovarian aging. 2/5

Happy to share a new @biorxivpreprint.bsky.social from the lab, led by talented postdoctoral fellow #MinhooKim: "Single-cell exploration of ovarian aging across vertebrate models", a meta-analysis study of public ovarian aging sc/snRNA-seq data! www.biorxiv.org/content/10.1... A 🧵, 1/5 🧬🖥️🧪 #GeroSky

I think mandating preprinting (like many private funders like CZI do) would be the perfect compromise instead of mandating gold OA and then restricting the amount of APC that can be spent. We always preprint before 1st submission in my lab, and I consider it the “director’s cut” anyway.

Undergrad flash talks are starting - the future of #Geroscience research is here!

😅

USC LDS Vice Dean Sean Curran opening the day!!!

#GLAM2025

#GLA2025 is on! attendees from all over and >100 trainee presentations (talks, flash talks, posters)!
Thanks to our sponsors for supporting the event!
#Hevolution @simonsfoundation.org @activemotifusa.bsky.social #CedarsSinai #Vwr #Echo #IDT and @cellpress.bsky.social editor Swapnila Ranu

So excited for #GLAM2025 tomorrow at the Cal Science Center! Looking forward to a day of great science from our LA and SoCal #Geroscience trainees, as well as a keynote from Pr Eileen Crimmins!

👀

The outrage is great, but the reality is gold OA is >>$2K, and capping the spending will have 2 effects: (1) only rich labs will be able to afford publishing in the most prestigious journals, (2) ECR who need these papers in their CVs will be screwed. At this point- not a victory for us scientists.

Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):

Age-dependent effect of environmental enrichment on the neural 3D chromatin interactome Gancedo-Verdejo et al. reveal age-associated molecular changes in mouse hippocampus and an age-dependent effect of environmental enrichment, focusing on 3D chromatin structure and gene expression. Environmental enrichment promotes aging-like changes in young mice, likely related to brain maturation; conversely, it reverts age-related alterations in old mice, suggesting neuronal rejuvenation.

Age-dependent effect of environmental enrichment on the neural 3D chromatin interactome

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways During aging and cellular senescence, repetitive elements are frequently transcriptionally derepressed across species and cell types. Among these, the most abundant repeats by copy number in the human...

🚨 Another preprint from the lab out today! 🚨
This work led by former trainee Dr. Juan Brado @the-te-guy.bsky.social and new grad student Ms. Eyael Tewelde, to undertstand how upregulation of a single retrotransposon (here, AluJB) impacts cellular phenotypes! A 🧵, 1/9
www.biorxiv.org/content/10.1...

REVIEW: Studying ovarian aging and its health impacts: modern tools and approaches
By Bérénice A. Benayoun, Alison Kochersberger, and Jennifer L. Garrison
➡️ genesdev.cshlp.org/content/39/1...

@bbparis1984.bsky.social @jennifergarrison.bsky.social
#reproductiveaging #ovary #aging #womenshealth

grants.nih.gov/grants/guide...

if you haven’t been paying attention a whole lot of countries just aren’t shipping to the US now because of tariffs

When boasting of 8-day to 1st decision (and charging >10K APC), it is unbelievable to be unable to provide not even a timeline to 1st decision to authors after ≥6 weeks. #Scientific #publishing is just broken. I hope my trainees can get a respectful and timely review of their work elsewhere. 2/2

A story in 2 panels: submission of a manuscript on July 11th, 6 weeks ago. Inexistent communication from the journal, and a status as "with editor" the whole time. Emailed for an update after 4 and 5 weeks of inactivity. 1/2
#AcademicRant 🧪🧬

What do you do when a journal has been sitting on a manuscript for almost 6 weeks and there still hasn’t been a decision on whether to send out for review? #SMH 🤦‍♀️🤦‍♀️🤦‍♀️

Sex differences in tissue-specific immunity and immunology Biological sex exerts a substantial influence on the immune system and immune-related diseases. Males are more susceptible to the acute effects of viral disease and certain cancers, whereas females ex...

www.science.org/doi/10.1126/...

@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease.

Details below
careersearch.stanford.edu/jobs/computa...

Plz RT

Please read the whole piece.

It's devastating. The cruelty at every turn is hard to stomach, the indignity of it all.

When reading about Dr. Wu, I see a lot of my mom. About seeing work as a calling and pushing as long as possible, despite the devastating effects of racism and sinophobia.

Had to try this out with insects and HOO BOY is this embarrassing.

Assistant Professor in Aging - Montréal, Quebec (CA) job with IRIC – Université de Montréal | 12842218 This is for an Assistant or Associate Research Professor position in Aging

Faculty position in aging in Montreal!

www.nature.com/naturecareer...

An absolutely awful turn of events. I am heartbroken over the firing of the Flybase staff. Thanks to @claudia-lopez.bsky.social for covering this important story.