Happy to share this paper led by super talented postdoc Michele Chirichella at @astrazeneca.bsky.social Published in @cp-cellsystems.bsky.social
All kudos to him. Glad to have contributed as academic advisor and with some experiments and data.
Hopefully first of many !
I’m excited to recruit a postdoc to join my lab at NIAID (Rocky Mountain Labs). We study mucosal immunity and vaccine responses to respiratory viruses in a collaborative, supportive environment.
Details & apply: www.training.nih.gov/jobs/pdf-miv...
#Postdoc #Immunology #Virology #NIHJobs
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Mucosal delivery of influenza antigens using a replication deficient adenovirus supports broadly reactive antibody responses and heterologous viral immunity in the respiratory tract of animals https://www.biorxiv.org/content/10.1101/2025.10.13.682194v1
I am really excited to see this article on basic experimental design principles published. Definitely will be mandatory reading for incoming graduate students in my lab. Maggie Wagner who led this article did an amazing job with the illustrations of basic principles www.nature.com/articles/s41...
New review paper from the influenza group
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...
Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social
www.biorxiv.org/content/10.1...
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
Last chance TODAY - to register and submit abstracts for #EMBObarrierTissues in Basel 🇨🇭🇨🇭🇨🇭! We've hit our registration goal 🥳, but there's always room for more. Join @maurogaya.bsky.social and me to explore the latest in lymphocyte and mucosal immunology. Details: meetings.embo.org/event/25-bar...
Congrats Danica 😀
Very proud of Danica Besavilla, PhD student in the lab, receiving the Poster award at the #Antibodies & Complement meeting, taking place in Catania.
She presented her paper on mAbs to #Influenza #Neuraminidase , just published in @natureportfolio.nature.com #npjViruses
www.nature.com/articles/s44...
Proud to announce our new technique for tracking relative B cell clonality in situ with B Cell Receptor MERFISH (BCR-MERFISH)! Congratulations to Evan Yang and our colleagues in the Carroll laboratory! Check out our bioRxiv: www.biorxiv.org/content/10.1... 1/9
Our @immunolcellbiol.bsky.social "Highlights of 2024: Germinal Centers" is now out. Led by Theresa Pankhurst, we discuss some (there's never enough space for all!) neat germinal centre papers that were published in 2024, and whose findings are moving the field forward. doi.org/10.1111/imcb...
Postdoctoral position in Computational Biology open !
Our Lab is trying to understand the molecular and cellular mechanisms involved in establishing intestinal immune homeostasis and how a breakdown of these mechanisms may lead to diseases
More info 👇 :
lnkd.in/dQZq55nv
lnkd.in/d6sbw59P
The American Society for Microbiology is committed to ensuring that scientific research is conducted adhering to strict standards for biosafety and biosecurity, but pausing research is not the path forward. Read our statement: asm.org/press-releas...
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
In @jem.org, Conlon, Huang, and Gerner show that immunization generates concentration gradients of antigens and #inflammation across interconnected chains of lymph nodes that regulate the magnitude and heterogeneity of adaptive immunity. rupress.org/jem/article/...
Neat @pnas.org paper from @angelettilab.bsky.social & @matsbemark.bsky.social on ectopic germinal centres in the nasal turbinates of mice and humans. doi.org/10.1073/pnas...
Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination @angelettilab.bsky.social
www.pnas.org/doi/10.1073/...
Thank you, Marty!
Thank you! This work opened up a lot of questions, which we hope to answer in future studies
Thank you @maurogaya.bsky.social , looking forward to the meeting!
And I forgot to thank the collaborators, without whom the work would have not been possible.
@matsbemark.bsky.social for continued discussions and key scientific input.
#KaWeiTang for swabs #JohanHellgren and team for tonsils
Other lab members: #NimithaMathew , #LauraReusch and #KarinSchön above all
We show that the same structures are also present at steady state, after vaccination and also in humans.
Our work adds to recent studies that identified DALT, nasal immunity and ectopic GC in skin.
We thank the funders @vetenskapsradet.bsky.social , @kawresearch.bsky.social and @erc.europa.eu !
Interestingly, another old paper described M cells in mouse nasal turbinates.
By sequencing we showed that germinal centers in nasal tissue were essentially transcriptionally identical, but clonally distinct, to those in cervical lymph nodes and NALT. (5/N)
But we found some old studies describing nasal tissue immunity after influenza infection in absence of NALT and cervical lymph nodes. Indeed, we could confirm ectopic germinal centers in the nasal turbinates by microscopy. Cells express AID, we also found Tfh and FDCs. (4/N)
By flow cytometry, a lot of these cells looked like germinal center B cells and followed the same dynamics as those in secondary lymphoid organs (and were antigen specific).
We were confused because we had carefully removed the NALTs before running them. (3/N)
First, Romain showed that by infecting with higher viral titer in lower volume we can increase viral replication in nasal tissue and also had more B cells within the cervical lymph node and nasal tissue itself (2/N)
Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
Cool germinal center acrobatics from Juhee Pae et al, check it out!
www.nature.com/articles/s41...
