Insights on downstream immunity from blood methylome signatures in children exposed to maternal type 1 diabetes #T1D #Genetics #Epigenetics www.nature.com/articles/s42...
06.11.2025 12:06 β π 4 π 3 π¬ 0 π 0@eaphelps.bsky.social
Associate Professor of Biomedical Engineering at the University of Florida. I study Beta Cell Biology, Biomaterials Engineering, and the Immunology of Type 1 Diabetes. https://www.bme.ufl.edu/labs/phelps/
Insights on downstream immunity from blood methylome signatures in children exposed to maternal type 1 diabetes #T1D #Genetics #Epigenetics www.nature.com/articles/s42...
06.11.2025 12:06 β π 4 π 3 π¬ 0 π 0Pleased to share our latest paper characterizing a beta cell specific GABA knockout by first-author and fantastic postdoc Sandra Ferreira
www.sciencedirect.com/science/arti...
LOVE the audio signal in the supplementary videos. Wonderfully creative interpretive aid for the reader/listener. Excellent data, cool work! Congrats!
17.09.2025 01:09 β π 2 π 0 π¬ 1 π 0New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky
13.09.2025 10:47 β π 5 π 2 π¬ 0 π 0Nuc Yellow
12.09.2025 13:00 β π 1 π 0 π¬ 0 π 0Pleased to share our latest article by first author @molliehuber.bsky.social focusing on beta cell function in living pancreas tissue slices from organ donors with T1D, a co-equal collaboration with Clayton Mathews. Includes live videos of insulitis in human T1D. #nPOD
www.cell.com/cell-reports...
I am excited to announce our paper βBeta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesisβ is out in Cell Reports! @eaphelps.bsky.social
www.cell.com/cell-reports...
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
First ADA 5k in the bag. #ADAChicago
22.06.2025 12:30 β π 6 π 0 π¬ 0 π 0What an amazing time to be a biomedical scientist.
www.nejm.org/doi/abs/10.1...
Human islet proteome changes in stage 1 type 1 diabetes reveals increased inflammation and decreased endoplasmic reticulum stress.
link.springer.com/article/10.1... π
I had a nightmare last night that I arrived at in-person NIH study section without having read a single assigned grant. And I was rev. 1 on the first grant up for discussion.
23.05.2025 13:15 β π 0 π 0 π¬ 0 π 0When a Decision on Manuscript email arrives a minute before you go out to celebrate your birthday
20.05.2025 16:36 β π 95 π 12 π¬ 3 π 1How academics imagine their lives would look like if they decide to work in tech
11.04.2025 19:15 β π 8963 π 1064 π¬ 311 π 287I'm the 1st scientist in my family. My parents were amazed I could attend @caltech.edu, an elite private school, for my PhD studies FOR FREE. In fact, I was paid to become a PhD chemist. STEM is a pathway to a good career. I study TB- a disease that impacts millions. Fund NIH.
13.05.2025 18:24 β π 158 π 24 π¬ 1 π 1Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!
www.biorxiv.org/content/10.1...
very sorry to hear about your loss of Rosa
16.04.2025 01:30 β π 1 π 0 π¬ 0 π 0Great session on biomaterials for beta cell replacement in T1D at #SFB2025. Thanks to all the speakers and co-organizer Jess Weaver.
11.04.2025 15:50 β π 3 π 0 π¬ 0 π 0CaMPARI2 provides a marker of beta-cell function, allowing high content analysis
Tracking Ca2+ responses in pancreas just got better! Our latest preprint by Charles Lazimi and Austin Stis showcases CaMPARI πΈ as a fixable functional marker in living pancreas slices. @cherie-stabler.bsky.social @linnemannlab.bsky.social
www.biorxiv.org/content/10.1...
#CalciumImaging #Diabetes
Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!
18.03.2025 15:15 β π 57 π 13 π¬ 4 π 0We're looking for postdoctoral scholars to join our team in Vancouver π¨π¦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
10.03.2025 23:48 β π 20 π 23 π¬ 0 π 1New aquarium denizens
09.03.2025 02:48 β π 1 π 0 π¬ 0 π 0Listen to my interview on our local NPR station @wuft.org show "Tell Me About It" to learn more about this awesome event to connect the public with the research we do on UF's campus. www.wuft.org/podcast/tell...
26.02.2025 20:02 β π 1 π 0 π¬ 0 π 0UF Biomedical Engineering STEM Outreach Day Date/Time Date(s) - 03/08/2025 10:00 am - 1:00 pm Location Reitz Student Union Join us on Saturday, March 8, 2025, from 10 a.m. to 1 p.m. at the Reitz Student Union on the UF campus for a free, family-friendly event designed to spark curiosity and inspire the next generation of STEM leaders. This outreach event is perfect for students in grades K-12, offering an exciting glimpse into the world of biomedical engineeringβa field where science, technology, engineering, and mathematics come together to revolutionize healthcare.
Saturday March 8 is UF Biomedical Engineering STEM Outreach Day! Come and learn about the amazing world of Biomedical Engineering. See how our incredible research impacts human health. Event is free and open to the public with free parking! Free cookies and lemonade too!
bme.ufl.edu/events/uf-bi...
Exiting the microscopy room
19.02.2025 11:57 β π 156 π 15 π¬ 4 π 2Proud to share a new preprint from my lab that is the product of hard work from several talented lab members and collaboration with valued colleagues: www.biorxiv.org/content/10.1...
21.02.2025 14:03 β π 15 π 6 π¬ 2 π 1We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction.
https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1
major FOMO
14.02.2025 00:26 β π 1 π 0 π¬ 1 π 0Leading the pack: Glucokinase reinforces Ca2+-waves
#PancSky #BetaCellSky
elifesciences.org/articles/103...
I love @journeytomicro.bsky.social
but they don't seem active on here, so I'm going to post my favorite videos of theirs here to spread their chill science vibes