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Ed Phelps

@eaphelps.bsky.social

Associate Professor of Biomedical Engineering at the University of Florida. I study Beta Cell Biology, Biomaterials Engineering, and the Immunology of Type 1 Diabetes. https://www.bme.ufl.edu/labs/phelps/

450 Followers  |  192 Following  |  25 Posts  |  Joined: 23.12.2023  |  1.9883

Latest posts by eaphelps.bsky.social on Bluesky

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Blood methylome signatures in children exposed to maternal type 1 diabetes are linked to protection against islet autoimmunity - Nature Metabolism Through an epigenome-wide blood analysis in children of mothers with or without type 1 diabetes, the authors identify epigenetic modifications of type 1 diabetes susceptibility loci through which mate...

Insights on downstream immunity from blood methylome signatures in children exposed to maternal type 1 diabetes #T1D #Genetics #Epigenetics www.nature.com/articles/s42...

06.11.2025 12:06 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Beta cell secreted GABA sets appropriate insulin secretion by modulating islet calcium oscillations Gamma-aminobutyric acid (GABA) is produced in pancreatic beta cells and is implicated in modulating islet function, yet its precise physiological role…

Pleased to share our latest paper characterizing a beta cell specific GABA knockout by first-author and fantastic postdoc Sandra Ferreira
www.sciencedirect.com/science/arti...

29.10.2025 18:37 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

LOVE the audio signal in the supplementary videos. Wonderfully creative interpretive aid for the reader/listener. Excellent data, cool work! Congrats!

17.09.2025 01:09 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators This study combines live pancreas tissue slices with adenoviral transduction of the Calcium Modulated Photoactivatable Ratiometric Integrator 2 (CaMPARI2) biosensor for high-throughput analysis of isl...

New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky

13.09.2025 10:47 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Nuc Yellow

12.09.2025 13:00 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses u...

Pleased to share our latest article by first author @molliehuber.bsky.social focusing on beta cell function in living pancreas tissue slices from organ donors with T1D, a co-equal collaboration with Clayton Mathews. Includes live videos of insulitis in human T1D. #nPOD

www.cell.com/cell-reports...

29.08.2025 17:57 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses u...

I am excited to announce our paper β€œBeta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis” is out in Cell Reports! @eaphelps.bsky.social
www.cell.com/cell-reports...

28.08.2025 14:24 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...

Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...

04.08.2025 23:38 β€” πŸ‘ 300    πŸ” 77    πŸ’¬ 12    πŸ“Œ 8
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First ADA 5k in the bag. #ADAChicago

22.06.2025 12:30 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

What an amazing time to be a biomedical scientist.

www.nejm.org/doi/abs/10.1...

21.06.2025 06:56 β€” πŸ‘ 115    πŸ” 19    πŸ’¬ 0    πŸ“Œ 1
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Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donor... Aims/hypothesis Progression to type 1 diabetes is associated with genetic factors, the presence of autoantibodies and a decline in beta cell insulin secretion in response to glucose. Very little is kn...

Human islet proteome changes in stage 1 type 1 diabetes reveals increased inflammation and decreased endoplasmic reticulum stress.
link.springer.com/article/10.1... πŸ”“

10.06.2025 14:35 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1

I had a nightmare last night that I arrived at in-person NIH study section without having read a single assigned grant. And I was rev. 1 on the first grant up for discussion.

23.05.2025 13:15 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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When a Decision on Manuscript email arrives a minute before you go out to celebrate your birthday

20.05.2025 16:36 β€” πŸ‘ 95    πŸ” 12    πŸ’¬ 3    πŸ“Œ 1
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How academics imagine their lives would look like if they decide to work in tech

11.04.2025 19:15 β€” πŸ‘ 8963    πŸ” 1064    πŸ’¬ 311    πŸ“Œ 287

I'm the 1st scientist in my family. My parents were amazed I could attend @caltech.edu, an elite private school, for my PhD studies FOR FREE. In fact, I was paid to become a PhD chemist. STEM is a pathway to a good career. I study TB- a disease that impacts millions. Fund NIH.

13.05.2025 18:24 β€” πŸ‘ 158    πŸ” 24    πŸ’¬ 1    πŸ“Œ 1
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Role of GLP1-receptor-mediated Ξ±-Ξ²-cell communication in functional Ξ²-cell heterogeneity. While the islet Ξ²-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual Ξ²-cells differ in their calcium dynamics and insu...

Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!

www.biorxiv.org/content/10.1...

29.04.2025 20:59 β€” πŸ‘ 11    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

very sorry to hear about your loss of Rosa

16.04.2025 01:30 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Great session on biomaterials for beta cell replacement in T1D at #SFB2025. Thanks to all the speakers and co-organizer Jess Weaver.

11.04.2025 15:50 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
CaMPARI2 provides a marker of beta-cell function, allowing high content analysis

CaMPARI2 provides a marker of beta-cell function, allowing high content analysis

Tracking Ca2+ responses in pancreas just got better! Our latest preprint by Charles Lazimi and Austin Stis showcases CaMPARI 🍸 as a fixable functional marker in living pancreas slices. @cherie-stabler.bsky.social @linnemannlab.bsky.social
www.biorxiv.org/content/10.1...
#CalciumImaging #Diabetes

26.03.2025 23:54 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Sitting in a journal club-style class right now and after the main presenters present, there are "roles" from others in the group, like the "archeologist" who looks into the citation trail, the "private investigator" who tries to dig into the history, and the "industry practitioner", etc. Cool idea!

18.03.2025 15:15 β€” πŸ‘ 57    πŸ” 13    πŸ’¬ 4    πŸ“Œ 0
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Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375 The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).

We're looking for postdoctoral scholars to join our team in Vancouver πŸ‡¨πŸ‡¦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...

10.03.2025 23:48 β€” πŸ‘ 20    πŸ” 23    πŸ’¬ 0    πŸ“Œ 1
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New aquarium denizens

09.03.2025 02:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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UF Biomedical Engineering STEM Outreach Day Dr. Edward Phelps of the University of Florida J. Crayton Pruitt Family Department of Biomedical Engineering talks about STEM Outreach Day on Saturday, March 8 from 10 a.m. to 1 p.m. in the UF Reitz U...

Listen to my interview on our local NPR station @wuft.org show "Tell Me About It" to learn more about this awesome event to connect the public with the research we do on UF's campus. www.wuft.org/podcast/tell...

26.02.2025 20:02 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
UF Biomedical Engineering STEM Outreach Day

Date/Time
Date(s) - 03/08/2025
10:00 am - 1:00 pm

Location
Reitz Student Union

Join us on Saturday, March 8, 2025, from 10 a.m. to 1 p.m. at the Reitz Student Union on the UF campus for a free, family-friendly event designed to spark curiosity and inspire the next generation of STEM leaders. This outreach event is perfect for students in grades K-12, offering an exciting glimpse into the world of biomedical engineeringβ€”a field where science, technology, engineering, and mathematics come together to revolutionize healthcare.

UF Biomedical Engineering STEM Outreach Day Date/Time Date(s) - 03/08/2025 10:00 am - 1:00 pm Location Reitz Student Union Join us on Saturday, March 8, 2025, from 10 a.m. to 1 p.m. at the Reitz Student Union on the UF campus for a free, family-friendly event designed to spark curiosity and inspire the next generation of STEM leaders. This outreach event is perfect for students in grades K-12, offering an exciting glimpse into the world of biomedical engineeringβ€”a field where science, technology, engineering, and mathematics come together to revolutionize healthcare.

Saturday March 8 is UF Biomedical Engineering STEM Outreach Day! Come and learn about the amazing world of Biomedical Engineering. See how our incredible research impacts human health. Event is free and open to the public with free parking! Free cookies and lemonade too!
bme.ufl.edu/events/uf-bi...

26.02.2025 19:58 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Exiting the microscopy room

19.02.2025 11:57 β€” πŸ‘ 156    πŸ” 15    πŸ’¬ 4    πŸ“Œ 2
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IFN-Ξ± Induces Heterogenous ROS Production in Human Ξ²-Cells Type 1 diabetes (T1D) is a multifactorial disease involving genetic and environmental factors, including viral infection. We investigated the impact of interferon alpha (IFN-Ξ±), a cytokine produced du...

Proud to share a new preprint from my lab that is the product of hard work from several talented lab members and collaboration with valued colleagues: www.biorxiv.org/content/10.1...

21.02.2025 14:03 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 2    πŸ“Œ 1

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction.

https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1

21.02.2025 12:40 β€” πŸ‘ 41    πŸ” 22    πŸ’¬ 1    πŸ“Œ 2

major FOMO

14.02.2025 00:26 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Glucokinase activity controls peripherally located subpopulations of Ξ²-cells that lead islet Ca2+ oscillations 3D light-sheet imaging identifies the location and metabolic sensitivity of Ξ²-cell subpopulations that lead and coordinate islet Ca2+ oscillations.

Leading the pack: Glucokinase reinforces Ca2+-waves
#PancSky #BetaCellSky

elifesciences.org/articles/103...

13.02.2025 20:29 β€” πŸ‘ 8    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
Why Do Planarians Have Those Triangles on their Heads?
YouTube video by Journey to the Microcosmos Why Do Planarians Have Those Triangles on their Heads?

I love @journeytomicro.bsky.social
but they don't seem active on here, so I'm going to post my favorite videos of theirs here to spread their chill science vibes

12.02.2025 22:22 β€” πŸ‘ 17    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

@eaphelps is following 19 prominent accounts