Marc Stadler

Exploring the Substitution of the C21‐OAc Moiety in [11]Cytochalasans: Synthesis and Evaluation of Fluorophore Conjugates Via in silico docking of pyrichalasin H on G- and F-actin, the C21-OAc moiety is identified as a modifiable site tolerated for actin binding. Fluorescent [11]cytochalasan probes from pyrichalasin H a....

Thanks to all collaborators! Check out our new publication on: "Exploring the Substitution of the C21-OAc Moiety in [11]Cytochalasans: Synthesis and Evaluation of Fluorophore Conjugates" chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Collage der Portraits von Andreas Keller, Max Kellner und Marc Stadler

Drei Forscher des HZI sind #HighlyCited2025: Andreas Keller @helmholtzhips.bsky.social, @mjkellner.bsky.social und @ms-fungi.bsky.social wurden von @clarivateag.bsky.social für ihre vielfach zitierte Forschung ausgezeichnet. Herzlichen Glückwunsch! 🎉
www.helmholtz-hzi.de/media-center...

Researchers reveal how mitonuclear interactions can either enhance or impair key qualitative and quantitative traits—contributing to improved fruiting body yield or, conversely, triggering oxidative stress and hybrid breakdown in the model system 𝑃𝑙𝑒𝑢𝑟𝑜𝑡𝑢𝑠 𝑜𝑠𝑡𝑟𝑒𝑎𝑡𝑢𝑠.

🔗 doi.org/10.3897/imaf...

Unveiling an asymmetric plant–fungal symbiosis: morphological, cytogenetic, and molecular characterization of a haploid Epichloë festucae strain associated with three polyploid cytotypes of the Iberia... The ecological and evolutionary outcomes of plant–fungal interactions are strongly influenced by genome size and ploidy, yet the ploidy level of both partners is rarely assessed simultaneously. Epichl...

A previously undocumented symbiosis is described: a haploid 𝐸𝑝𝑖𝑐ℎ𝑙𝑜ë 𝑓𝑒𝑠𝑡𝑢𝑐𝑎𝑒 strain consistently colonising the Iberian endemic 𝐹𝑒𝑠𝑡𝑢𝑐𝑎 𝑟𝑜𝑡ℎ𝑚𝑎𝑙𝑒𝑟𝑖 across its three polyploidy cytotypes.

🔗 doi.org/10.3897/imaf...

Lichtmikroskopie von roten Blutzellen, einzelne mit Plasmodium infiziert (violett). ©Armin Passecker

Jährlich sterben etwa 600.000 Menschen an einer Malaria-Infektion und immer mehr Erreger sind gegen bestehende Medikamente resistent. Forscher:innen am @helmholtzhips.bsky.social & @swisstph.ch haben nun einen Wirkstoff mit einem neuen Wirkmechanismus entwickelt.
www.helmholtz-hzi.de/media-center...

Fluoreszenzmikroskopie von Zellen in magenta und blau

Einem Team um @togulab.bsky.social @helmholtzhips.bsky.social gelang es, Strategien zur Herstellung von #Furanoliden zu entwickeln. Diese #Naturstoffe sind Wirkstoffkandidaten gegen Infektions- und Krebserkrankungen. www.helmholtz-hzi.de/media-center...
📷HIPS; CC-BY 4-0 DOI: 10.1021/jacs.5c08354

Phylogenetic assessment and taxonomic revision of Scytalidium (Helotiales, Leotiomycetes) Members of Scytalidium are primarily saprotrophic and are known for their ability to colonize a variety of substrates, including soil, decaying plant material, and wood. During an investigation of soi...

Researchers revise the genus 𝑆𝑐𝑦𝑡𝑎𝑙𝑖𝑑𝑖𝑢𝑚, expanding its species diversity and geographical distribution, and laying the foundation for future taxonomic research.

🔗 doi.org/10.3897/imaf...

Scientists describe 10 new species of wood-decaying fungi and reveal that 𝐶𝑒𝑟𝑖𝑝𝑜𝑟𝑖𝑎 and 𝑀𝑒𝑟𝑖𝑝𝑖𝑙𝑢𝑠 lineages emerged during the late Cretaceous period ~80-83 million years ago.

🔗 doi.org/10.3897/imaf...

Including a position in my group to work on Evolutionary Genomics of Fungal pathogens

Cordypyridones E–J: Antibiofilm 2-Pyridone Alkaloids from the Nematode Antagonistic Fungus Laburnicola nematophila In the course of biochemical prospection of Laburnicola nematophila isolated from eggs of the plant-parasitic cyst nematode Heterodera filipjevi, eight 2-pyridone alkaloids were isolated from its solid-state BRFT cultures and identified as six previously undescribed, cordypyridones E–J (1–6), and two known congeners, cordypyridones C (7) and D (8). The structures and absolute configurations of all isolated compounds were elucidated through HR-ESI–MS, 1D/2D NMR spectroscopy, and TDDFT–ECD calculations. Compound 4, bearing a rare N-hydroxy-2-pyridone moiety structurally related to that of PF1140, exhibited broad-spectrum bioactivity in cytotoxicity and antimicrobial assays. Compounds 5 and 6 demonstrated potent antibiofilm activities against Staphylococcus aureus, reducing its biofilm formation by almost 50% at 0.25 and 7.8 μg/mL, respectively.

pubs.acs.org/doi/10.1021/...
JNP just published our paper on new biolactive metabolites from a nematode parasitic fungus. Some of them have strong anti-biofilm effects. Thanks to @MSCActions (#Mycobiomics), @AVHStiftung & Landwirtschafliche Rentenbank for funding & congrats to all coauthors!

#structuralbiology #biomolecularanalysis #scientificsymposium #chembiochem #biophysics #drugdiscovery #ai #biomolecules | LD Organisation - Scientific Conference Producers Discover the final programme of ChemBioChem and ChemPhysChem 25th Anniversary Symposium on Advances in Structural Analysis of Biomolecules! Join us for 1,5 days of exciting science showcasing:  >> 14...

Join us in Berlin for the 25th Anniversary Symposium of ChemBioChem and ChemPhysChem on October 23rd and 24th. There will be a great line-up of speakers! www.cbc-cpc2025.org/programme

www.linkedin.com/posts/ld-org...

CC: @chemistryeurope.bsky.social

Three new species and one new record of Scleroderma (Sclerodermataceae, Boletales) from northern Thailand The genus Scleroderma (Sclerodermataceae) contains gasteroid ectomycorrhizal fungi and is distributed worldwide in temperate and tropical regions. Fresh specimens were collected in Thailand and report...

mycokeys.pensoft.net/article/1604...
Finally Yok's last paper from her successful PhD thesis where she worked at #Mae Fah Luang University and with us at #HZI (among others) on Thai Earthballs is also out. It was just published by #Mycokeys. Congrats to all co-authors & thanks for funding from RRI!

Deadly drug-resistant fungus spreading rapidly through European hospitals Health authorities race to contain fungus that survives routine disinfection.

Candidozyma auris breitet sich in immer mehr europäischen Kliniken aus. Der multiresistente Pilz kann bei immungeschwächten & vorerkrankten Personen schwere #Infektionen verursachen. @uk.theconversation.com berichtet über die Verbreitung & nötige Hygienemaßnahmen: theconversation.com/deadly-drug-...

New molecular analysis excludes 𝐸𝑛𝑡𝑒𝑟𝑖𝑑𝑖𝑢𝑚 from the order Cribrariales, revealing three distinct subgenera and clarifying evolutionary relationships in bright-spored Myxomycetes.

🔗 doi.org/10.3897/imaf...

Annotation and functional prediction of RNA helicases in Ustilago maydis RNA helicases are conserved enzymes found in both prokaryotes and eukaryotes. They function in all aspects of RNA metabolism and are known to influence various cellular and metabolic processes. In add...

Detailed annotation of 46 RNA helicases in 𝑈𝑠𝑡𝑖𝑙𝑎𝑔𝑜 𝑚𝑎𝑦𝑑𝑖𝑠 uncovers their potential roles in fungal growth, stress response, and plant pathogenesis, informing strategies to curb crop diseases.

🔗 doi.org/10.3897/imaf...

Chemical diversity of three lichens of genus Graphis (Graphidaceae) of the tropical dry forest from the northern region of Colombia - Mycological Progress Lichens are specialized complex ecosystems formed by algae/fungi living in interspecific symbiosis, which produce secondary metabolites that function as a defense against pathogens/competitors and/or external abiotic factors acting as antibiotics, antifeedants, UV protectants, etc., but also as a tool for taxonomy of lichen-forming fungi. However, the lichen substance content of crustose lichens of the genus Graphis from Colombian tropical dry forests has been poorly explored. In this work, the chemical composition of total extracts from three lichens belonging to the genus Graphis collected in the tropical dry forests of northern Colombia was determined by TLC/HPLC–DAD/MS (ESI); and from one of them, two depsidones were isolated/structurally characterized (LC-HRMS, 1H-13C (DEPT135, HSQC)-NMR). Consequently, the main findings were as follows: (i) stictic (1)/constictic (2), norstictic (5), and protocetraric (13) acids were the representative depsidones for G. dendrogramma (Tubará), G. dendrogramma (Piojó), and G. supracola, respectively; and (ii) the isolated depsidones from G. dendrogramma (Tubará) were stictic ( −)-(1) and constictic ( +)-(2) acids. These results provided key insights into the chemical diversity and taxonomic biomarkers of these species, and therefore, it could be concluded that (i) there was chemical variability between G. dendrogramma collected in different places, although all contained stictic acid–derived depsidones; (ii) for the first time, extrolites other than protocetraric acid (13) were identified for G. supracola, as well as norstictic acid (5) as major lichen substance for G. dendrogramma; (iii) the main chemical biomarker [stictic acid (1)] reported in the scientific literature for one of G. dendrogramma sample (Tubará) was confirmed (by LC–MS and NMR analysis); and (iv) for the first time, the specific optical rotation related to the chirality of the two isolated depsidones was determined [( −)-(1), ( +)-(2)].

link.springer.com/article/10.1...
Our new paper in collaboration with Colombian lichenologists has jut been published by #Mycological Progress. Congrats to all co-authors and thanks for #DAAD for funding!

he Department of Plant Pathology at the University of California, Davis is seeking applications for a fulltime, tenure-track Assistant Professor position in Mycology, with a focus on plant pathogenic, symbiotic, or mycotoxigenic fungi and fungal-like organisms (e.g., oomycetes). We are looking for a highly motivated and creative scientist with a strong background in mycology and/or the biology of fungi and fungal-like organisms that interact with plants. The successful candidate will be expected to develop a world-class, externally funded research program that integrates both fundamental and applied aspects of fungal biology within the context of plant pathology. We welcome applicants pursuing a wide range of research topics related to plant-associated fungi, including but not limited to mechanisms of fungal pathogenesis or symbiosis with plants, population genomics and evolution of fungal plant pathogens, plant-associated fungal microbiomes and plant-microbe interactions, and/or one health approaches to fungal diseases and antifungal resistance. Applicants working in other relevant research areas involving pathogenic, symbiotic, or mycotoxigenic fungi or fungal-like organisms that affect plant health are also encouraged to apply. The successful candidate will have significant opportunities for collaboration with faculty in plant pathology, microbiology, genomics, and agricultural sciences, and to contribute to addressing issues of importance to California’s agricultural and natural ecosystems. The appointee primary teaching responsibilities will be teaching Introductory Mycology, an upperdivision lab class, and SAS 30, Mushroom, Molds & Society, a general education class for non-majors. Additional graduate and undergraduate teaching responsibilities may be assigned based on departmental needs and the candidate’s expertise. The department offers modern instructional facilities, including a newly renovated teaching laboratory.

Please repost -- The Univ. California Davis dept of Plant Pathology is hiring a Fungal biologist / Mycologist

Applications due Dec 1

Application portal: recruit.ucdavis.edu/JPF07339

Screenshot shows part of the job posting (with alt-text of the same text)

Drought stress responses revealed by genomic and transcriptomic analyses of two macrofungi (Inonotus hispidus and Inocutis levis) from Populus euphratica Populus euphratica is a key deciduous and tall arbour capable of forming forests in arid and desert environments, exhibiting notable tolerance to drought, salinity and bacterial resistance. This study...

Whole-genome and transcriptome analyses of two drought-resistant macrofungi from arid 𝑃𝑜𝑝𝑢𝑙𝑢𝑠 𝑒𝑢𝑝ℎ𝑟𝑎𝑡𝑖𝑐𝑎 forests show distinct genetic mechanisms for surviving extreme water scarcity.

🔗 doi.org/10.3897/imaf...

I have noted the same. Impossible to put them all on the spam blacklist as they even change the email domain all the time..

Studying the decomposition of pine and spruce wood, researchers found that 𝐼𝑠𝑐ℎ𝑛𝑜𝑑𝑒𝑟𝑚𝑎 𝑏𝑒𝑛𝑧𝑜𝑖𝑛𝑢𝑚 can function either as a strong competitor or as a co-coloniser with 𝐻𝑒𝑡𝑒𝑟𝑜𝑏𝑎𝑠𝑖𝑑𝑖𝑜𝑛 𝑎𝑛𝑛𝑜𝑠𝑢𝑚, with interaction outcomes determined by isolate origin and host tree species.

🔗 doi.org/10.3897/imaf...

Mit Wissenschaft hautnah in Berührung kommen – beim #ScienceTalk im #phaeno! Am 18.09. zeigt HZI-Forscher Christian Sieben @christian-7.bsky.social die „Kommunikation zwischen Virus & Zelle“. Eintritt frei und hybrid vor Ort & online! Neugierig geworden? Näheres unter: www.phaeno.de/veranstaltun...

A hidden diversity of stromatal metabolites of 14 newly described Annulohypoxylon species, and diagnostic keys for identification, with Rostrohypoxylon reduced to synonymy under Annulohypoxylon.

🔗 𝐅𝐮𝐥𝐥 𝐚𝐫𝐭𝐢𝐜𝐥𝐞:
https://f.mtr.cool/madfhtfvwn

www.ingentaconnect.com/content/wfbi...
In our new paper we have described several new species of Hypoxylaceae and found that the genus Rostrohypoxylon is obsolete because it is nested in Annulohypoxylon in the multi-locus phylogeny. Secondary metabolite profiles of all taxa are also reported.

Onygenales from marine sediments: diversity, novel taxa, global distribution, and adaptability to the marine environment The Onygenales represent a versatile group of fungi that primarily inhabit soils, degrading cellulose and/or keratin. While some are known human pathogens, others are osmotolerant or colonize chitin s...

Researchers unveil six novel onygenalean fungi from Mediterranean marine sediments, highlighting their global diversity, salty adaptability, and potential roles in ocean nutrient cycles.

🔗 doi.org/10.3897/imaf...

📣🍄🦇🍄🦇🍄📣
I am looking for a postdoctoral researcher for my lab in Ceske Budejovice, Czechia. We study biodiversity monitoring, ecology, conservation, and microbiology. Some of our work deals with bats, most with fungi! Email at danny dot haelewaters at gmail dot com if interested. #TeamLaboul #newPI

Linalool-triggered plant-soil feedback drives defense adaptation in dense maize plantings High planting density boosts crop yields but also heightens pest and pathogen risks. How plants adapt their defenses under these conditions remains unclear. In this study, we reveal that maize enhance...

Very interesting!

Guo et al.

Linalool-triggered plant-soil feedback drives defense adaptation in dense maize plantings | Science www.science.org/doi/10.1126/...

Folge 3: Warum verlieren Antibiotika ihre Wirkung? Wie kommt es zu Resistenzen? Was genau passiert da in der Bakterienzelle? Und welche Alternativen gibt es zu klassischen Antibiotika? Darum geht es in der neuen Folge.

Ohne #Antibiotika keine moderne #Medizin – doch die Wunderwaffe verliert an Wirkung: #Bakterien entwickeln Resistenzen. Wie #multiresistente #Keime entstehen & warum #AMR zu den größten Gesundheitsrisiken zählt, erklärt der Podcast "Mikroben im Visier": mikroben-im-visier.podigee.io/3-neue-episode

Coprophilous fungi in the search for new antimicrobials and other beneficial natural products Covering: up to 2025Microbial interactions involve complex processes shaped by their ecological contexts. Herbivore animal dung denotes an interesting ecological niche for the study of interorganism c...

pubs.rsc.org/en/content/a...
Our new review on the secondary metabolites of coprophilous fungi has just been published by Natural Product Reports. Thanks for funding from the @humboldt-foundation.de foundation.de, the @dfg.de & the @daadworldwide.bsky.social Congrats to all coauthors!

Although polar, high altitude montane and cold desert environments harbour only sparse plant life, they do provide an environment for numerous new species of fungi

🔗 𝐅𝐮𝐥𝐥 𝐚𝐫𝐭𝐢𝐜𝐥𝐞:
https://doi.org/10.3114/sim.2025.112.03

Brown locusts, Locustana pardalina, host fluconazole resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains Abstract. The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is

#Candida auris from insects! amazing!
Brown locusts, Locustana pardalina, host fluconazole resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains url: academic.oup.com/mmy/article/...