Raghunath M

How mRNA Vaccines Can Help Fight Cancer Turning "cold" tumors "hot"

How do mRNA vaccines help fight cancer?
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...

Same here.

abg showing severe metabolic acidosis in a pt with esrf

See it to believe it! The heights(depths) of compensation! #nephsky

#morningrun

Useful guidance for bashing reviewers in the face when they talk beyond their expertise.

Determining sample size for pilot trials: a tutorial

www.bmj.com/content/bmj/...

Acanthocyte - phase contrast (original mag x400) - from patient with hydralazine-induced vasculitis #UrineMicroscopy #UrinarySediment

Hydranca strikes again. I just wonder whether we are missing a lot of hydralazine induced vasculitis here in our place. Hydralzine+- nitrate is such a big hit among our cardios. Or is there a race predeliction for this? 🤷

#gardenfeed
Bridal bouquet in rain

2/2 whats against MEST score? it being a snapshot in time? no trial evidence?

1/2 They say MEST scoring shouldn't inform Rx decisions. But it does, doesn't it? Witha high M/E score you would like to give strong antinflamm rx; you would think twice about giving steroid/mmf with S1/T2 score. So it does influence your choice in a way.
#nephsky

Very subtle 😂

Had a doctor patient, 37M, few days back with young onset HTN and USG showing AML and few cysts b/l. No family history. Have advised genetic testing. Let's see.

Thank you

Can someone make sense of this figure? It's from the nephjc article on EMPAKIDNEY followup trial. Does this mean that the longer you remain on sglt2is, the benifit wanes over time? Am I reading that right? #nephsky

I spoke about 'Biomarkers in AKI' at the Critical Care Nephrology Conference (CCNA 2.0) at Mumbai earlier today. A short tutorial.
#AKI #CCNA2.0
1/18

Tamil one. 'Margan'.

Scene from a movie where a doctor comments on a high BP in a patient.

The doctor asks the nurse to give iv hydralazine for the BP . We all know nephrologists hate hydralazine.

When even movie script writers reach for hydralazine so fast, nephrologists don't stand a chance! @hswapnil.medsky.social
@kidneyboy.bsky.social

Not in Trichur I assure you😁. See them every night.

1/ July 16 is #WorldSnakeDay - raising awareness of the incredible diversity of snakes and their vital role in our ecosystems. But did you know snakebites can also cause acute kidney injury? Join me, Dr. Fong Voon Ken, as we discuss their impact, management, and the need for awareness.

SGLT2i in CKD: impact beyond kidneys

🔻 15% all-cause hospitalizations
✅ Consistent regardless of eGFR, UACR & diabetes
🏥 ~36 fewer hospitalizations per 1000 pt-years

Large absolute gains for patients & health systems

Meta-analysis in @asnpublications.bsky.social

journals.lww.com/cjasn/pages/...

@nephjc.bsky.social
#nephjc Raghunath, nephrologist from Kerala, India. No COI. Mostly lurking and learning.

And I thought clonidine was just an antiHTNsive only

#nephsky Hi! What do you guys would work best in a patient with bx proven IC-MPGN? Nephrotic synd + creat 2. Workup for paraprotein, infection and autoimmune ds negative.
Rtx or CNI or MMF?

Check out this from Dr Meghan Sise #NephGR for us on the topic

youtu.be/qFYVhjpnYIU?...

#OncoNeph #NephSky

Here in Kerala, India, this would make us think of a viral infection like Dengue. Or even Leptospirosis (but expect the TLCs to be high). Then scrub typhus.

Tough!

A 7-year-old lioness reunites with the man who raised her after she was abandoned as a cub 🦁❤️ He slept beside her outside so she'd grow up as naturally as possible. Now she tackles him with love-hugs, face rubs, pure joy-until they collapse in a pile of trust. 🫶 #WildBond #HeartmeltingNature

Wait, but this is is anuric pts!

This is interesting. I usually continue loops in dialysis patients if they have at least 300ml /d of output left. Some vindication, i guess.

#nephsky query!
When you have ⬆️K, is there a rule as to how much aldo should rise? i hv a pt with K consistently around 5.5 and aldo level 14.2ng/dl, DRC 1.33mIU/ml, would you say that the aldo is inappropriately nrml & this is hyporeninemic hypoaldo?
@kidneyboy.bsky.social @hswapnil.medsky.social