Marc Bühler marcbuhler - Bluesky Statics

💫 We're hiring! The Computational Biology Facility is looking for a Computational Proteomics Scientist to collaborate on cutting-edge proteomics projects, develop new analytical approaches, and publish impactful research.
Apply by April 12 at: www.fmi.ch/education-ca...

19.02.2026 12:21 — 👍 13 🔁 13 💬 0 📌 2

Job opening for one of the most important positions at our institute.

04.12.2025 09:02 — 👍 4 🔁 1 💬 0 📌 0

We are hiring-join us!

08.09.2025 10:31 — 👍 24 🔁 25 💬 0 📌 0

Kudos to @aheljo.bsky.social and the entire team for this important contribution to our mechanistic understanding of chromatin repression by the ChAHP complex. 🧬👏

06.07.2025 11:58 — 👍 3 🔁 0 💬 0 📌 0

In conclusion, we propose that ChAHP represents a functional module that enables sequence-specific targeting of chromatin remodeling activity to counteract the binding of other chromatin regulators.

06.07.2025 11:57 — 👍 1 🔁 0 💬 1 📌 0

ADNP binding to chromatin is independent of CHD4, and CHD4’s ATP-dependent remodeling activity is not required for its recruitment to these sites. Instead, CHD4 functions to restrict the access of other TFs, such as CTCF, to ChAHP target sites.

06.07.2025 11:57 — 👍 1 🔁 0 💬 1 📌 0

The prevailing view is that chromatin remodelers promote transcription factor (TF) binding by making chromatin more accessible. However, this paradigm is reversed in the case of the transcription factor ADNP and the chromatin remodeler CHD4 within the ChAHP complex.

06.07.2025 11:56 — 👍 1 🔁 0 💬 1 📌 0

Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin Transcription in eukaryotes is regulated by chromatin-based mechanisms that control nucleosome occupancy, chromatin modifications, and transcription factor binding. We have previously shown that the transcription factor ADNP forms the ChAHP complex with the chromatin remodeler CHD4 and HP1 proteins, acting as a site-specific regulator of transcription and antagonist of CTCF binding. However, the molecular basis of these functions remained unclear. Here, we demonstrate that the CHD4 subunit is essential to antagonize CTCF and silence transcription of transposons, while HP1 proteins are dispensable. Although the remodeling activity of CHD4 is not required for ChAHP chromatin association, it is critical for both transposon repression and CTCF antagonism. Our findings support a model wherein ADNP recruits chromatin remodeling activity in a sequence-specific manner, enabling transcriptional control and local modulation of chromatin architecture. ### Competing Interest Statement The Friedrich Miescher Institute for Biomedical Research (FMI) receives significant financial contributions from the Novartis Research Foundation. Published research reagents from the FMI are shared with the academic community under a Material Transfer Agreement (MTA) having terms and conditions corresponding to those of the UBMTA (Uniform Biological Material Transfer Agreement). Novartis Research Foundation, n.a. Swiss National Science Foundation, grant 310030_188835

preprint alert: www.biorxiv.org/content/10.1...

06.07.2025 11:55 — 👍 42 🔁 12 💬 3 📌 2

Novel insights into the silencing of an understudied transposable element - check out our latest preprint by @jakobschnabl.bsky.social and colleagues

03.07.2025 06:33 — 👍 29 🔁 11 💬 0 📌 0

This work is not only an amazing resource for the community, it is also a total masterclass in code reusability, data FAIRness and reproducibility. Hopefully, this is the future!

26.02.2025 16:58 — 👍 14 🔁 5 💬 0 📌 0

A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin Transcription factors (TFs) are key regulators of gene expression, yet many of their targets and modes of action remain unknown. In Schizosaccharomyce…

The realignment of research in our group @fmiscience.bsky.social is beginning to bear fruit. Proud of our captain @merleskribbe.bsky.social and the whole team!
www.sciencedirect.com/science/arti...

27.02.2025 07:31 — 👍 43 🔁 15 💬 0 📌 0

Event poster for the 2025 TriRhena Gene Regulation Club in Strasbourg in Feb. 5. Listing the schedule, you can check here: https://www.ie-freiburg.mpg.de/gene-regulation-club

We are super excited. The 1st #TriRhena Gene Regulation Club in 2025 will take place this Feb. 5th at @igbmc.bsky.social in Strasbourg.

Organizer: @marcbuhler.bsky.social (@fmiscience.bsky.social), @tomsextonlab.bsky.social (IGBMC) & Nicola Iovino (MPI-IE):
www.ie-freiburg.mpg.de/gene-regulat...

03.02.2025 11:11 — 👍 9 🔁 4 💬 0 📌 0

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

16.12.2024 11:50 — 👍 110 🔁 117 💬 4 📌 7

FMI TFexplorer TFexplorer is a web application that can be used to explore experimentally determined interactions of transcription factors with proteins and DNA.

An Essential Bookmark for Your Web Browser
data.fmi.ch/TFexplorer/ 🌐

25.11.2024 08:45 — 👍 16 🔁 6 💬 1 📌 1

Nitrogen signaling factor triggers a respiration-like gene expression program in fission yeast | The EMBO Journal imageimageChemical cell-to-cell communication in the fission yeast Schizosaccharomyces pombe is essential for adaption to environmental changes in nutrient availability. This study uncovers that the e...

www.embopress.org/doi/full/10....

25.11.2024 08:36 — 👍 9 🔁 2 💬 0 📌 0

Posts by Marc Bühler (@marcbuhler.bsky.social)