Elliott Bernard

The week of publications continues for the lab with a @currentbiology.bsky.social piece on ninj1 by @elliottbernard.bsky.social and @ehartenian.bsky.social check it out to have all your pressing ninj1 questions answered :)

www.cell.com/current-biol...

The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage | The EMBO Journal imageimageThe innate immune sensor NLRP6 is known to control host defense against bacteria and viruses in the gastrointestinal tract by a poorly-understood mechanism. This study shows that NLRP6 forms...

Our latest work from @brozlab.bsky.social and led by @alexandraboegli.bsky.social is out now in @embojournal.org. Check out our findings on how the intestinal #inflammasome NLRP6 senses lysosomal damage to trigger pyroptotic cell death.

It's always a pleasure to spend the day out with the lab. Today was all about sharing our research and hearing about the other work going on in the department.

I was able to share and get valuable feedback on our latest insights on NINJ1 in #celldeath and #inflammation.

Registration opens soon for the second Pattern Recognition receptor symposium in Lausanne Switzerland in October 2025. Check out the link for the great list of speakers.

wp.unil.ch/immunobiolog...

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.

Registrations open March 1 - Attendance limited to 150 participants.

More info: wp.unil.ch/immunobiolog...

#ImmunoSky

#Pathogens #Lysosomes #CellDeath what's not to like? Check out our latest work deciphering how the protein NLRP6 links all of these to protect your gut from infections like Listeria.

Ninjurin-1 mediated plasma membrane rupture is a two-step process requiring cell swelling Plasma membrane rupture (PMR) and the release of cytosolic content are hallmarks of necrotic cell death. The plasma membrane protein ninjurin-1 (NINJ1) actively promotes cell lysis by polymerizing int...

And for our latest insights into how NINJ1 is activated and forms membrane-rupturing filaments during cells death, check out our recent preprint.
www.biorxiv.org/content/10.1...

Interested in learning more about NINJ1? My colleagues in the @brozlab.bsky.social, including @ehartenian.bsky.social, wrote a nice review of our current knowledge. www.cell.com/trends/bioch...

New research revealed how NINJ1 is kept inactive in living cells. Head over to Nature News & Views to check out our thoughts on these cool findings. Free to read at rdcu.be/d2nqH

Ninjurin-1 mediated plasma membrane rupture is a two-step process requiring cell swelling Plasma membrane rupture (PMR) and the release of cytosolic content are hallmarks of necrotic cell death. The plasma membrane protein ninjurin-1 (NINJ1) actively promotes cell lysis by polymerizing int...

If you're interested in knowing what I'm currently working on in the lab, we recently posted a preprint of our findings www.biorxiv.org/content/10.1...

I study cell death and inflammation and am also interested in how cells defend themselves against infection.