Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...
21.05.2025 18:59 β π 73 π 29 π¬ 2 π 0
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
If you always wanted to know the kinetics of how the Polycomb enzymes modify chromatin, we are thrilled to share our work!!! πππ§¬π¬
Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support!
doi.org/10.1126/scia...
22.05.2025 11:00 β π 23 π 5 π¬ 1 π 0
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. πππ
www.science.org/doi/10.1126/...
22.05.2025 10:47 β π 32 π 8 π¬ 0 π 2
Congratulations @matteodoudin.bsky.social for this PhD fellowship π₯³π. Stay tuned for his next achievements about nucleosome depletion.
22.05.2025 10:39 β π 5 π 1 π¬ 0 π 0
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity π
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky
04.02.2025 13:13 β π 43 π 17 π¬ 1 π 1
Scientific Graphic Designer & Illustrator, PhD
- Illustrations, covers, visual identities, etc.
Check out my website : https://kg-for-sciences.com/
Professor of Chemical Biology at @Uni_MR. Optochemical tools for controlling biological processes at molecular level. #ChemBioLovers #ChemicalEpigenetics #Photoswitches #Fluorophores #Photosensitizers. Be the Light!β¨β¨
Just another LLM. Tweets do not necessarily reflect the views of people in my lab or even my own views last week. http://rajlab.seas.upenn.edu https://rajlaboratory.blogspot.com
Scientific Director at MPFI | Developing optical & molecular tools for π§ research & π discovery | Baseball mom, swim mom & dog mom
Y. Eva Tan Professor in Neurotechnology, MIT. Investigator, HHMI. Leader, Synthetic Neurobiology Group, http://synthneuro.org. Scientist, inventor, entrepreneur.
Upconversion nanoparticles, optical biosensors, chiral spectroscopy, scicomm, blood oxygen | bass player | uranium glass collector
Group website: www.mackenzie-lab.org
he/him | Glasgow π΄σ §σ ’σ ³σ £σ ΄σ Ώ | Expect typos
Synapse modulation, biophysics, optogenetics, opsins, optoGPCRs & channelrhodopsins... garden stuff, photography, cats, cycling, parenting...still postdocing. Patch-clamper with imaging ambitions
https://scholar.google.com/citations?user=4xDsEF4AAAAJ&hl=en
Associate Professor at Cornell University: chemical biology, cell biology, #lipidtime and membrane biology
Professor at CU Boulder, Biochemistry, BioFrontiers Institute, Director College of Arts and Sciences Honors Program, zincophile, builder of fluorescence tools, cell gazer, single molecule tracker, researcher, teacher, mentor
Group Leader @ Janelia Research Campus, protein engineer, π³οΈβπ she/they
π«π·π¬π§ π§ββοΈ π΄π»
Postdoc at @SLCU Cambridge, plant biologist by day, Auxin biosensor and protein engineer by night π±π¬
Representing Team Biosensor at Sainsbury Laboratory Cambridge University. https://www.slcu.cam.ac.uk/research/jones-group
---Hormone biosensor engineering and imaging---
Biosensor developer, Recovering academic
I'm a microscopist | I like everything from fluorescent sensors to custom microscope hardware | I also do my best to garden in a Bay Area apartment
Royal Society University Research Fellow at the University of Sheffield. Interested in how ABA patterns control water fluxes in leaves using ABA biosensors and image analysis.
https://www.sheffield.ac.uk/biosciences/academic-staff/people/jim-rowe
Staff scientist, Gerst lab, Weizmann Inst.
Husband, father
Topics: Science, Molec/Cell Biology, RNA, microscopy, Tunneling Nanotubes, Sci fi.
Life in Israel (Hebrew)
Blogs: https://greenfluorescentblog.wordpress.com
https://flyingsaucermovies.wordpress.com
PI at the Uni Medical Center GΓΆttingen (UMG), Founder and CTO of NanoTag Biotechnologies. Using nanobodies for super-resolution microscopy in neurosciences. Opinions are my own.
Sharing speeds science! Addgene helps scientists around the world find and share research materials - plasmids, viral preps, antibodies, data, and more.
Amateur πΏ Biologist β’ Aspiring π» Designer
Independent Researcher at Binomica Labs
Degreeless Heathen β’ #diybio β’ #homelab
Open Lab Notebook: tinyurl.com/ATGCFFE
YouTube Channel: https://youtube.com/@atinygreencell
Cell biologist, Assistant professor @ Erasmus MC, Optical Imaging Centre (OIC). Postdoc alumnus @ UCSF. Interested in cytoskeleton dynamics, neuronal growth cones, live cell microscopy, optogenetics. Opinions are my own.
