Leuven Brain Institute

The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer’s disease - Molecular Neurodegeneration Advances Background Over 300 mutations in PSEN1 have been identified as causes of early-onset Alzheimer’s disease (EOAD). While these include missense mutations and a few insertions, deletions, or duplications...

'The curious case of a heterozygous loss-of-function #PSEN1 variant associated with early-onset #AlzheimersDisease'

Inmaculada Sanjuan-Ruiz, Lutgarde Serneels, Katleen Craessaerts...Bart De Strooper @leuvenbrainins.bsky.social @ukdri.ac.uk @viblifesciences.bsky.social

bit.ly/3L0QhK6

🌟 Congratulations to the laureates of the 2025 Queen Elisabeth Medical Foundation for Neuroscience scientific awards, which include two researchers from our Center!

Find out more 👉 cbd.sites.vib.be/en/news#/new...

Grateful for the opportunity to contribute to the ‪@eraneuron.bsky.social‬ MINERVA consortium on microglia/neuron crosstalk in autism – @leuvenbrainins.bsky.social‬, with amazing collaborators: Tarja Malm, Carsten Culmsee, Judith Alferink, Laura Ricceri! Exciting meeting @unimarburg.bsky.social!

Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism.
authors.elsevier.com/a/1l7HS5Sx5g...
Work from Ben Verpoort and colleagues, with special thanks to our collaborators.

Beyond CEN.PK - parallel engineering of selected S. cerevisiae strains reveals that superior chassis strains require different engineering approaches for limonene production Genetically engineered microbes are increasingly utilized to produce a broad range of high-value compounds. However, most studies start with only a ve…

📃🥳 Proud to share the latest research from our lab! Yanmei and colleagues used high-throughput screening and parallel metabolic engineering to optimize S. cerevisiae chassis strains for the production of limonene 🍋. You can read all about it here 👇: www.sciencedirect.com/science/arti...

❤️ Verliefdheid vergelijkbaar met dopinggebruik, commentaar door LBI lid professor biologische psychologie Rudi D'Hooge.

🚗 “Eigenlijk kan je het vergelijken met een nieuwe auto kopen, elke keer als je erin stapt, ben je gelukkig. Maar een jaar later is dat al een oude auto.”

@biopsylbp.bsky.social

YouTube video by VIB-KU Leuven Center for Brain & Disease Research Vlog Mass Spectrometry

⚡ This #TechnologyTuesday, we're being taken around the VIB Metabolomics Core Leuven with Bart Ghesquière, Camila Cologna and Pedro Magalhães! ✨

#metabolomics #proteomics #massspectrometry #biology #neuroscience #brain #research

www.youtube.com/watch?v=EZuA...

Congrats on this milestone Dr Crotti 👏

📣 Scientists led by Sandrine Da Cruz have successfully seeded the accumulation of TDP-43—a hallmark of ALS and frontotemporal dementia—using lab-engineered protein fragments 🧠🔬 Find out more 👉 cbd.sites.vib.be/en/news#/new...

Generalization and extinction of platform-mediated avoidance in male and female rats Scientific Reports - Generalization and extinction of platform-mediated avoidance in male and female rats

🚨Paper alert!!🚨

Excited to share out latest research where we investigated avoidance, fear generalization and extinction learning using a modified platform-mediated avoidance procedure in male and female rats.

rdcu.be/eesmc

Het Leuvense biotechbedrijf Augustine Therapeutics heeft bij een kapitaalronde 77,7 miljoen euro opgehaald.

LBI leden prof Ludo Van Den Bosch & dr @robertprior.bsky.social (@cbdresearch.bsky.social) geven duiding bij dit belangrijke en hoopvolle nieuws dat extra zuurstof geeft aan het onderzoek.

🧠 On 19 March, Paris Brain Institute hosted the meeting of the CURE-ND 2025 alliance, bringing together the heads of the 4 partner institutions (@dzne.science, Mission Lucidity at @leuvenbrainins.bsky.social ky.social, @ukdri.ac.uk, PBI) to drive advances in research into neurodegenerative diseases.

YouTube video by VIB-KU Leuven Center for Brain & Disease Research Vlog Bioimaging Core

⚡ It's #TechnologyTuesday, and to kick-start the series we have a tour of the VIB Bioimaging Core by Pablo Hernández-Varas! 🔬 (1/4)

www.youtube.com/watch?v=hKUy...

💙 Leuven Brain Institute and its members support World Down Syndrome Day today 💛

#brainresearch #neuroscience #leuvenbraininstitute

🧠 #BrainAwarenessWeek aan het #LeuvenBrainInstitute

💡Gisteren werden leerlingen van het Sint-Pieterscollege Leuven ondergedompeld in de wondere wereld van het brein

🔬Lezingen door @lucasmergan.bsky.social & @eliskbv.bsky.social, demo’s door @cbdresearch.bsky.social @viblifesciences.bsky.social

Mooi nieuws op Dag Zeldzame Ziekten: LBI bestuurslid prof Patrik Verstreken krijgt dit jaar de Prijs Generet voor zeldzame ziekten van de Koning Boudewijn Stichting 🏆

Bekijk de infofilm hier images.app.goo.gl/xZ9z9187JH7m...

Of lees erover hier
kbs-frb.be/nl/1-miljoen...
@cbdresearch.bsky.social

De voorbije maand was heel druk met oa de lancering van het nieuwe Leuven Childhood Epilepsy Center 💓 en tijdens het weekend zetten maar liefst 20 onderzoeksgroepen en labo’s hun deuren open voor Insight / Inside KU Leuven 🧠

Alle foto’s en lezingen via deze weg: www.kuleuven.be/brain-institute/nl

🏆 Congratulations to LBI members drs Laura Luyten & Esther Klinger for obtaining an Brain & Behavior Research Foundation grant to either extend research fellowship training or begin careers as independent research faculty 🇺🇸

@bbrfoundation.bsky.social @lauraluyten.bsky.social @estherkli.bsky.social

Very excited to share that our collaborative research between @kuleuvenuniversity.bsky.social and the University of Cadiz is now available in the European Journal of Pediatric Neurology🎉Curious to know more about corpus callosum and cerebral palsy?🧠👀 --> doi.org/10.1016/j.ej...

‘Madammeke? Het is mevrouw’: Vlaamse ouderen hebben het gehad met betutteling

LBI directeur & ouderenpsychiater prof Vandenbulcke in @tijd.be

Lees het volledige artikel gratis via deze link

www.tijd.be/politiek-eco...

#LeuvenBrainInstitute
@upckuleuven

Detection, extraction and skeletonization of 🐭🧠 vessels from brain-wide angiograms acquired using fUS.

🎥 of the procedure : tinyurl.com/bdh46v6f