Sarah Gray, MD MPH

Nerandomilast in Patients with Progressive Pulmonary Fibrosis | NEJM Nerandomilast (BI 1015550) is an orally administered preferential inhibitor of phosphodiesterase 4B with antifibrotic and immunomodulatory properties. Nerandomilast has been shown to slow the progr...

www.nejm.org/doi/full/10....

Nerandomilast in Patients with Idiopathic Pulmonary Fibrosis | NEJM Nerandomilast (BI 1015550) is an orally administered preferential inhibitor of phosphodiesterase 4B with antifibrotic and immunomodulatory effects. In a phase 2 trial involving patients with idiopa...

www.nejm.org/doi/full/10....

ERS 2025: Boehringer shares additional data for lung fibrosis therapy Pooled Phase III data show Boehringer Ingelheim's nerandomilast may reduce death risk in pulmonary fibrosis, IPF and PPF.

📢 FDA approves Nerandomilast in IPF, first new pulmonary fibrosis drug in over a decade. Slower progression of FVC decline and a (non-significant) trend toward improved mortality (FIBRONEER-IPF, FIBRONEER-ILD)

#pulmsky #ILD #IPF

druganddeviceworld.com/2025/10/02/e...

^ this 100x over. If you give them a diabetic diet in the hospital and then at home they eat whenever they want, their sugars will not be well controlled at home. Figure out what meds they need (diuretic, anti-HTN, insulin) for the food they will be eating at home

FDA approves new twice-yearly HIV shot. What to know The FDA approved Gilead's HIV prevention drug lenacapavir, a twice-a-year injectable medication that clinical trials show prevents new infections.

A bit of positive news today. FDA has just approved Lenacapavir for PrEP in the US. In clinical trials one injection every 6 months was close to 100% effective in preventing HIV transmission.
PrEP is for everyone who needs it.
www.usatoday.com/story/news/h...

Jan 30, 2025:

“CHEST remains steadfast in our mission to prevent, diagnose, and treat chest diseases using all available means to advance the best patient outcomes. We maintain that striving for health equity is essential to achieving this goal”

www.chestnet.org/newsroom/che...

Here’s my hang up in this. I used to be just the “Covid/flu/RSV panel” only kinda gal - because those could potentially affect therapies. Full panel was just for immunocompromised. But now our full RVP includes mycoplasma, which is helpful to know 🤷‍♀️

I’ve had decent luck with Breyna in the last year for sure as well after everyone dropped Symbicort from formulary.

The loss of fluticasone HFA is crushing. As as adult doc I don’t often need it, but so many friends/family/colleagues with kids who literally are out of options since it was dropped

#medsky

@robyncohenmd.bsky.social - I know we’ve both had mixed luck with Symbicort because of NDC blocks. Have you had anyone try the BI coupons?

Hopefully with the addition of GSK, we’ll have at least one option on formulary for patients

Boehringer Ingelheim (since 6/2024)
Spiriva or Atrovent
(*I have not had anyone try this one)

- COVERED- just show up at the pharmacy
-NOT covered get a co-pay card
Atrovent: patient.boehringer-ingelheim.com/us/products/...
Spiriva: patient.boehringer-ingelheim.com/us/products/...

AstraZeneca (since 6/2024)
(Also has to be on formulary, no NDC block)

AirSupra, Symbicort, Breztri* or Bevespi: 

*Breztri has a $0 co-pay card for commercial insurance

- Go to the AstraZeneca website or call to get a co-pay card: 

azpatientsupport.com
1-800-236-9933

GSK Coupons and Free Trial Offers | GSKForYou Find more information about the coupons and free trial offers that may be available for the medicines you are taking. Eligibility criteria apply.

GSK:

Advair, Anoro, Arnuity, Breo, Incruse, Serevent, Trelegy*

*Trelegy has a $0 co-pay card for commercial insurance

Go to the GSK website to get a co-pay card:
gskforyou.com/programs/gsk...

Heads up inhaler peeps!
Jan 1 GSK joined AZ and BI for the $35 inhaler list, adding:
Advair, Anoro, Arnuity, Breo, Incruse, Serevent, Trelegy

NOTES
-only for commercial insurance or uninsured. NOT Medicare/Medicaid
-has to be on formulary, no PA/NDC block

Not ideal, but a start
details —>
#pulmsky

🙄🙄🙄

This may be a silly question… but are they running under part B? Nebs are run under part B, but a lot of pharmacies mistakenly try to bill/charge them under part D. Happens way too often. It’s the first thing our nurses check if nebs are denied, so I’m guessing its it’s not as easy as a fix as that

Dec 25, Disney+!

With the case? I’m not sure - this was exploratory info/looking at preICU care. I was dismissed after/not involved further

With the dep? We moved on from the sepsis definition. Later split hairs when asked if a pH 7.3 was an acidosis… it is an alkalemia, but might be both acidosis/alkalosis physio

I was once a respondent in discovery in a deposition and the lawyer posed a question along the lines of “what (lab/VS) defines sepsis” buckle up, friends. Let’s just say she did not get the answer she was looking for. Got into how scoring systems aren’t actually definitions of the syndromic process

Used to be at a place that did 2. 1 is so much more manageable. Spouse holding down the home front for 1 week vs 2 weeks makes a huge difference for home balance too

People would be surprised how many times ivc/fvc doesn’t meet the quality guidelines. We need good data to make good decisions!

🙋‍♀️

🙋‍♀️ please!

Guilty of this trap as well/waiting for a “big chunk” of time. Looking forward to your progress and hopefully will help to motivate some new behaviors of my own!

Pizza for sure. Definitely have to do lunch food. By the time you get home it will be late for families to to lunch and nap without meltdowns. We’ve done pizza and donuts for morning parties

AAAAI come out pretty strong against inhaled epi as well!

It was for a healthcentral article. I even warned them before the interview that my stance would be I would not recommend

(And I just went to fact check myself - looks like they ended up finding someone else and did publish a piece on “when to use otc inhalers” a month or two later still)

I once was asked to give and interview about otc primatene mist… in summary I just kept reiterating “no, I would not recommend because…” and listed all the reasons why and all the better alternatives. The article did not end up getting printed

🙋‍♀️ would love to be included

Always on the look out in my asthma clinic! These things can go unrecognized for so long. And now with biologics, we have so many more options to help