Carlo Maley

We are excited to announce a new clinical trial - adaptive therapy for metastatic ER+ breast cancer at Mayo Clinic AZ (NCT06525766). Adaptive therapy manages the evolution of the cancer to extend survival time and reduce toxicity (improve quality of life). bit.ly/4cehaWe

I was listening to the AI generated music of The Velvet Sundown as a thought provoking exercise. I think it is wrong to think of generative AI as being made by a machine, with no humans trying to communicate something. It is more like a melding pot chorus of humanity, and interesting as such.

I'm looking forward to the big AACR Cancer Evolution conference in Albuquerque Dec. 4-6: www.aacr.org/meeting/aacr...

We are hiring a postdoc to profile the evolvability of tumors in longitudinal samples from three clinical trials as part of the ARPA-H ADAPT program. This is essentially an evolutionary bioinformatics position. If you are interested, please apply here ASAP apply.interfolio.com/172521

YouTube video by Arizona State University Research What evolution can teach us about outsmarting cancer, with Carlo Maley

If you are interested in our research about discovering species with extremely low cancer rates or using ideas from integrated pest management to improve cancer therapy, ASU has a new podcast Lab Coat Optional that featured my work in an episode: www.youtube.com/watch?v=P8r0...

YouTube video by ProSocial World Science of Imagined Worlds: Evolution+Ecology for World Builders |Carlo Maley & Vaughn Aktipis-Maley

My son and I were interviewed by David Sloan Wilson about the article we published with Beckett Stearner on using evolution and ecology for world building in fiction. We also ended up talking about prosocial issues. www.youtube.com/watch?v=BS74...

We just published a fun article on applying evolution and ecology to world building (for authors and gamers). It's based on a talk I gave at GenCon last year. www.prosocial.world/special-publ... @prosocialworld.bsky.social
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Special Publications This series of special publications features edited collections of essays written by leading experts in their respective fields, exploring the intersection of evolution and human society. Through these thought-provoking contributions, the series examines how evolutionary science can inform our understanding of the arts, culture, and social systems, offering fresh insights into how cultural evolution and cooperation can drive positive change in the world.

Evolution & Ecology for World Builders is a science-powered guide to making your creatures, races, and ecosystems make sense — no biology degree required. www.prosocial.world/special-publ...
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Resistance Management for Cancer: Lessons from Farmers Abstract. One of the main reasons we have not been able to cure cancers is that treatments select for drug-resistant cells. Pest managers face similar challenges with pesticides selecting for pesticid...

We just published a review of lessons farmers have learned for how to control pesticide resistance from evolving, and how to apply those to oncology to prevent cancers from evolving therapeutic resistance: bit.ly/48OfFdX

Cancer Prevalence across Vertebrates Abstract. Cancer is pervasive across multicellular species, but what explains the differences in cancer prevalence across species? Using 16,049 necropsy records for 292 species spanning three clades o...

We are excited to announce that a 10 year project to gather and analyze veterinary necropsy data to discover cancer prevalence across (292) vertebrate species has finally been published open access in Cancer Discovery @aacr bit.ly/40nCqmH #componc #cancer #AcademicSky