Filipa Simões

Filipa Simões

@simoesfilipa.bsky.social

Development and Regeneration of the Heart | Cardio-Immuno Genomics | Group Leader University of Oxford IDRM-DPAG | playing with zebrafish & cardiac organoids | academic mama of 2 children & 1 dog | curiosity led

3,177 Followers 723 Following 124 Posts Joined Oct 2023
1 day ago
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Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

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1 day ago

Excited to share my new preprint from the McKinley lab, where we explored regenerative mechanisms across menstruation and pregnancy! We thought specialized glands would regenerate everything.

We were wrong.

But the real mechanism turned out to be way cooler :) 🧪🧵
www.biorxiv.org/content/10.6...

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2 days ago
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Applications are now open for the Stem Cell & Development Biology Early Career Symposium!

Together with @isscr.org and @socdevbio.bsky.social, we're hosting a scientific symposium focused on incubating the next generation of research leaders.

Apply by 5/1 at: https://bit.ly/4lriiZm

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1 day ago
LinkedIn This link will take you to a page that’s not on LinkedIn

We are looking for a Postdoc to join our lab at @oxfordbiochemistry.bsky.social. This is a dry-lab focused post on the computational analysis of long read single-cell sequencing data to understand the role of transposable elements (TEs) in early development. my.corehr.com/pls/uoxrecru... #TEsky

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2 days ago
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Today at SY-Stem: Marianne Bronner, California Institute of Technology, presented on “Gene regulatory subcircuits controlling neural crest stem cell fate along the body axis.”

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2 days ago
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Don’t deprioritize curiosity-driven research Around the world, governments are demanding that research funding follow broader political priorities. They should be careful what they wish for.

A very important editorial:

Don’t deprioritize curiosity-driven research www.nature.com/articles/d41...

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3 days ago

Some background to this, and an example I think of Phil's attitudes towards fostering students and encouraging others. I never got a chance to meet Phil in person, but will share his act of generosity that helped myself and @hdashnow.bsky.social and I think had in indelible mark on our careers. 1/8

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4 days ago
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Remembering Phil Bourne Personal reflections on a legendary scientist, leader, builder, and mentor

'Phil was also the founding Editor-in-Chief of PLOS Computational Biology, where he created the beloved Ten Simple Rules series. He was so prolific in the series that the meta-article “Ten Simple Rules for Writing a PLOS Ten Simple Rules Article” literally includes, as Rule 4: “Be Philip E. Bourne.”

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1 week ago
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🚨 Job Alert - Please share! 🙏

Interested in 3D gene regulation in development & evolution? 🤓🧬

💥 Our lab at @cabd-upo-csic.bsky.social is expanding!

We’re recruiting:
✅ PhD students
✅ Postdocs
💻🧪 Experimental or computational backgrounds welcome

👇 Details below

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4 days ago
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Gene regulatory networks: from correlative models to causal explanations Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations"

Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations?

rdcu.be/e7zx7

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5 days ago

I love this, Teresa!!

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5 days ago
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#WomanInScience

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1 week ago
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In imaging-based spatial transcriptomics (Xenium CosMx), 40% RNAs are Not assigned to segmented cells

This amazing preprint @fabiantheis.bsky.social studies the origin, heterogeneity & biological inference (Modeling cell protrusion/contacts😎) of unassigned RNAs

www.biorxiv.org/content/10.6...

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1 week ago
A blue round cake. The cake has a blue 30 on top, and some white drawings of zebrafish embryos. The cake sits on a wooden table.

30 years of the Schier Lab @schierlab.bsky.social 🐟🧪

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1 week ago

We are one of the potential host labs for a Lecturer position in Molecular Genetics & Genomics — please share, and get in touch for more info! 🧬📣

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1 week ago
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Congratulations to all awardees of ISSCR Early Career Impact Award but specially to @nmoris.bsky.social and @nicolasrivron.bsky.social with many thanks for their efforts to navigate and shape the ethical issues associated with the emerging field of a #SCEmbryoModels #SCBEM

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1 week ago
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What a pleasure to host @hsiuchuanlin.bsky.social @crg.eu to @idrm.ox.ac.uk @oxforddpag.bsky.social! We discussed in much depth novel technologies pushing forward the engineering human cell fate space- looking forward to exciting collaborations 🤩 And always a treat to visit @jesusoxford.bsky.social!

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1 week ago
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🚨3-year Postdoc Position @halloulab.bsky.social (Kennedy Institute, Oxford) - on Spatial Biology & Bioinformatics of Fibrosis🚨

An exciting project combining #SpatialTranscriptomics & #Mechanobiology👇:

shorturl.at/LLS5r

Deadline: 16 March - Please RT 📢!

@kiroxford.bsky.social @ox.ac.uk

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2 weeks ago
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Bridging the gap (axonal regeneration in zebrafish recorded live!)

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2 weeks ago
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Karolinska Institute is hiring for 7 new positions!

Individual job details below!👇

#ScienceJobs

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2 weeks ago

💯

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2 weeks ago

In addition to all the well-documented stresses on the system, reviewer fatigue/saturation drives worse reviews which in turn promotes more journal shopping by authors which leads to paper recirculation and, yes, you guessed it, more reviewer fatigue 😵‍💫

@reviewcommons.org @asapbio.bsky.social

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2 weeks ago
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Fantastic launch to our exciting @wellcometrust.bsky.social #UNICIL project in Exeter with a symposium entirely dedicated to our favourite things #MotileCilia with our teams & new friends! Great things ahead under @micromotility.bsky.social ‘s helm.. @jekely.biologists.social.ap.brid.gy /1

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2 weeks ago

This afternoon I took my mom to the ballet. She was as a dancer and choreographer for decades & has been in memory care for 8 years. She can’t recall many details of her past but dance—and her identity as a dancer—lives in her soul 1/
#alzheimers

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3 weeks ago
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Jennifer Doudna’s $1 Billion Plan To Bring Gene Editing To The Masses Crispr’s ability to cut genetic code like scissors has just started to turn into medicines. Now, gene editing pioneer Jennifer Doudna wants to build an entire ecosystem to bring these treatments mains...

“The best that I can do in terms of making the next breakthrough or discovery is not to do it by myself, but to enable other scientists to do it”
— Jennifer Doudna

www.forbes.com/sites/amyfel...

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1 month ago
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Happy birthday to one of my favourite haters, Charles Darwin

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1 month ago
YouTube
Women in Science 2026 YouTube video by BiozentrumBasel

Happy International Day of Women & Girls in Science🧪. To mark this day, we feature three female scientists from our core facilities and share their professional journeys, which reflect the diversity of careers in science. #WIS #STEM
👉 www.biozentrum.unibas.ch/research/res...

youtu.be/BVkxirHBqJk

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1 month ago
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Happy International Day of Women and Girls in Science! 🧪 Don't forget to send in your nominations for the FEBS | EMBO #WomenInScience Award.

Deadline: 15 May

Read more:
https://www.embo.org/the-embo-communities/febsembo-women-in-science-awardees/nominate-for-the-women-in-science-award/
#award

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1 month ago
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Whole-body Single-cell Spatial transcriptomic atlas of adult Danionella ~1 cm long

scRNAseq
MERFISH (500-gene)
HCR

Endothelial cell podxl+ (Fig S8)

Vascular vs Visceral mural cell (Fig S10)

Peter Reddien lab bioRxiv 2026
www.biorxiv.org/content/10.6...

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1 month ago
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Happy International Day of Women and Girls in Science! 🧪

The EMBO Women in Science Lectures address issues related to gender and diversity in science.

Find out more and apply here:
https://www.embo.org/funding/lecture-travel-and-childcare-grants/women-in-science-lectures/

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