Morandi Research Group

Congrats to Emilien, Maurus and Giorgia! Metal- and CO-Free Carbonylation of Alkyl Iodides @jacs.acspublications.org pubs.acs.org/doi/abs/10.1...

Great to see this published!

In short, we introduced causal inference logic to test which of metal electronics, ancillary ligand sterics and metal coordination number (CN) directly affect the rate of reductive elimination at Pd(II) (and presumably other metals...)

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Congrats Bence on this @orgsynth.bsky.social prep describing a scalable nitrogen insertion protocol. Thanks to the Dixon lab for checking. 10.15227/orgsyn.102.0465

Congrats to Sooyeon Moon, Julia Reisenbauer, Ann-Sophie Paschke, Alessandro Scotto, Luca Terraneo, Niklas Brenner, as well as collaborators from Spirochem AG Quentin Lefebvre, Thomas Fessard for a continuous flow nitrogen atom insertion. @chemcomm.rsc.org @Innosuisse. pubs.rsc.org/en/content/a...

Congrats to @mixalhsmpogdos.bsky.social, @sevenroediger.bsky.social, @fruepp.bsky.social, Nathalie, Patrick, Fabio and Jan on this epic study of C-N red. elim. in @jacs.acspublications.org - using causal inference, organometallics, electrochemistry, kinetics and DFT. pubs.acs.org/doi/full/10....

YouTube video by ETH News for Industry Recycling of organic pollutants: Nominated for the Spark Award

Congrats to Alberto and Patrick! @ethz.ch. youtu.be/NcMTOI25yb8?...

Congrats to @fruepp.bsky.social, Vasily Grebennikov, Mykola Avramenko, Marc-Olivier Ebert "Kinetic, Spectroscopic, and Computational Investigation of Oxidative Aminative Alkene Cleavage Reveals an N-Iodonium-Iminoiodinane Pathway" now @chemrxiv.org - chemrxiv.org/engage/chemr...

Congrats to Ann-Sophie Paschke, @ybraegger.bsky.social, Bence Botlik, Erich Staudinger, @origreen.bsky.social! "Carbon-to-nitrogen atom swap enables direct access to benzimidazoles from drug-like indoles". www.nature.com/articles/s41.... @natchem.nature.com.

Their electrochemical Lindane destruction has so much potential. Just thinking about the Lindane scandal in Basel-Kleinhüningen, where it was mixed into the street concrete…

Join us today to hear from Ann-Sophie Paschke and Stefanie Schiele from the @morandilab.bsky.social about their work on C-to-N atom swapping reactions!! Thanks to Karim for hosting and editing!

Link: youtu.be/D513hX1gOTg

@chemicalscience.rsc.org
doi.org/10.1039/D5SC...

Congrats to Elliott, @hls111.bsky.social, Olivera, Patrick, Alexander and Daniel! Ligand Design Enables the Palladium-Catalyzed Intermolecular Carbochlorocarbonylation of Alkynes and Cyclopentenone Formation @jacs.acspublications.org pubs.acs.org/doi/full/10....

Last day at #eucomc2025 starts with #plenary lecture @morandilab.bsky.social 🇨🇭 @ethz.ch introducing new concepts for atom and funcional transfer #Ni #organicsynthesis

Congrats to Ann-Sophie Paschke, Eva Meeus, Florin and our collaborators from the pharmacy institute M. Masota and @nathalie-grob.bsky.social - Late-Stage Diversification of Peptides and Peptide Drugs through Nitrogen Atom Insertion | @ChemRxiv - go.shr.lc/44mL6Kg

Congrats to Tanner Jankins, Barnabé Berger, Françoise A. Aouane, Sergio Barbeira-Arán, Christophe Didier, Bettina Hürlimann and Claudius Zimmer: C–H Functionalization via Single Atom Metathesis of C–H and C–X Bonds @jacs.acspublications.org pubs.acs.org/doi/10.1021/...

Efficient Optimization and Synthesis of Diverse Azaarenes via Nitrogen Atom Insertion under Continuous Flow Conditions We report the development of a continuous flow approach to nitrogen atom insertion. The setup is modular, enabling the rapid optimization of reaction conditions for a wide range of substrates. The mil...

Congrats to Sooyeon Moon, Julia Reisenbauer, Ann-Sophie Paschke, Alessandro Scotto, Luca Terraneo, Niklas Brenner, as well as collaborators from Spirochem AG Quentin Lefebvre, Thomas Fessard for a continuous flow approach to nitrogen atom insertion. @Innosuisse. chemrxiv.org/engage/chemr...

Chemodivergent C-to-N atom swap from benzofurans to benzisoxazoles and benzoxazoles Facile derivatization of biologically active compounds without prefunctionalization expands the chemical space and accelerates the discovery of new molecules. Atom swap reactions have recently emerged...

Congrats to Ann-Sophie Paschke, Stefanie Schiele, Camille Pinard, and Filippo Sandrini: Chemodivergent C-to-N atom swap pubs.rsc.org/en/content/a.... Please also check our other paper (10.26434/chemrxiv-2024-prwm8) as well Studer's work.

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My lab at @ethzurich.bsky.social is looking for a motivated PhD student. We develop chemical tools for advanced fluorescence microscopy 🔬 and work at the interface of synthetic chemistry ⚗️ and protein engineering 🦠. Sharing with skilled Master students appreciated. More info at tinyurl.com/2dbjk5ty

Metal Electronics Mediate Steric and Coordination Number Effects on Palladium (II) C–X Reductive Elimination Reductive elimination is the key bond-forming elementary step in many transition metal catalyzed reactions relevant to the synthesis of pharmaceuticals, materials and fine chemicals. Metal electronics...

Congrats to @mixalhsmpogdos.bsky.social, @sevenroediger.bsky.social, @fruepp.bsky.social, Patrick, Nathalie, Fabio on this epic study of the factors governing reductive elimination - using causal inference, organometallics, electrochemistry, kinetics and DFT
@chemrxiv.bsky.social go.shr.lc/4j8O5MM

Palladium-Catalyzed Transfer Iodination from Aryl Iodides to Nonactivated C(sp3)–H Bonds We report a new strategy for the catalytic iodination of nonactivated C(sp3)–H bonds. The method merges the concepts of shuttle and light-enabled palladium catalysis to employ aryl iodides as both hyd...

Many congrats to Emilien Le Saux for this new publication in @jacs.acspublications.org describing a catalytic approach to Transfer Iodination from Aryl Iodides to Nonactivated C(sp3)–H Bonds.
pubs.acs.org/doi/10.1021/...

Our @snf-fns-ch.bsky.social research project "Hypervalent iodine reagents for peptide and protein modification and applications in chemical biology" has been accepted! 2 PhD and one postdoc positions are now open @lcsolab.bsky.social For more details to apply, See:

www.epfl.ch/labs/lcso/gr...

Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds The synthesis of nitrogen-containing molecules through carbon–nitrogen (C–N) bond formation is critical for the discovery and preparation of medicines, agrochemicals, and materials. Here, we report th...

Many Congrats to @ybraegger.bsky.social,
Ann-Sophie Paschke, Nima Nasiri, Bence Botlik
and Francesco Felician for this masterpiece! Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds in Science, @ethzurich.bsky.social.
www.science.org/doi/10.1126/...

Are you inspired by complex reaction mechanisms and organometallic chemistry? At the European Symposium on Organic Chemistry (@ESOC_ISC) in Copenhagen (www.esoc2025.com) Jennifer A. Love (
@jenlove.bsky.social
) and Bill Morandi (
@morandilab.bsky.social
) will share their latest results!

Some Items of Interest to Process R&D Chemists and Engineers

Congrats to @sevenroediger.bsky.social and team as well as Tanner Jankins and team for having their papers highlighted this month in OPRD items of interest to process chem 😀 pubs.acs.org/doi/10.1021/...

It is time to say good bye to @pfritz.bsky.social. Aside from being a stellar PhD student, Patrick has contributed immensely to lab organization, You will be missed Patrick! At the same time, we are also very much excited for his new chapter in @morandilab.bsky.social . You will do great things!

Thank you 😀