Versiti Blood Research Institute

Quick peek at the 2nd deck concrete pour of the VBRI expansion! From groundbreaking 11 months ago to this milestone! We're building the future of blood health research day by day. #PublicHealth #BloodHealth

The Kastrup Lab @ VBRI recently published a technique that may prevent dangerous blood clots after trauma without stopping normal healing. The targeted siRNA therapy keeps clotting proteins in the safe zone in the murine model. Learn more: journals.lww.com/jtrauma/abst...

We're proud to stand with our colleagues at @ash.hematology.org and the #Fight4Hematology campaign. Supporting emerging researchers and innovative care approaches strengthens our entire field's capacity to transform lives. Learn more and get involved: www.hematology.org/advocacy/fig...

Congratulations to Bob Montgomery @versitiresearch.bsky.social for the being the recipient of the 2025 Harold R. Roberts Award @isth.org #ISTH2025

🥳The ISTH proudly presents the Harold R. Roberts Award to Dr. Robert R. Montgomery in recognition of his enduring contributions. His decades of leadership through the ISTH SSC and @versitiresearch.bsky.social reflect a career shaped by curiosity, perseverance & impact.

Read more: bit.ly/3FO1cVe

Versiti - Brian Curtis, PhD | Versiti Blood Research Institute Dr. Curtis is the senior director of diagnostic hematology and director of the Platelet & Neutrophil Immunology Lab.

Learn more about the Curtis Lab at VBRI: versiti.org/our-experts/...

PF4-dependent P-selectin expression assay in comparison to the heparin-induced platelet activation assay for the diagnosis of heparin-induced thrombocytopenia - PubMed These findings suggest that the PEA is a promising functional test for HIT laboratory diagnostics based on the relatively high sensitivity; however, further studies are needed to validate its clinical...

PF4-dependent P-selectin expression assay in comparison to the heparin-induced platelet activation assay for the diagnosis of heparin-induced thrombocytopenia

pubmed.ncbi.nlm.nih.gov/40191970/

Versiti - Subramaniam Malarkannan, PhD | Versiti Blood Research Institute Dr. Malarkannan is the Gardetto Chair for Immunology and Immunotherapy and a senior investigator at Versiti Blood Research Institute.

Learn more about the Malarkannan Lab and their work: versiti.org/versiti-bloo...

Supercharged NK cells, unlike primary activated NK cells, effectively target ovarian cancer cells irrespective of MHC-class I expression - PubMed The use of sNK cells in immunotherapy emerges as a potentially effective strategy to target and eliminate the majority of ovarian tumour clones, thereby providing a potential therapeutic opportunity i...

Supercharged NK cells, unlike primary activated NK cells, effectively target ovarian cancer cells irrespective of MHC-class I expression: pubmed.ncbi.nlm.nih.gov/40196236/

Great work and great collaboration! #TeamScience

Learn more about Dr. Alan Mast and the Thrombosis and Hemostasis Lab at Versiti: versiti.org/versiti-bloo...

Join us on Wed. 4/23 as we showcase the groundbreaking work of women in science at the VBRI!

All ages are welcome as we profile the impactful innovation coming from @versiti.bsky.social and inspire future researchers.

Register for free: versiti.org/ways-to-give...

#WeResearchCures

At Versiti Perspective: Sickle Cell Disease, experts, advocates and community members joined to advance awareness and research. Guests heard from Chris Miskel, Prithu Sundd, Ph.D., and more, toured VBRI and learned their blood type. Give blood, save lives: bitly.versiti.org/3DaSHlw.

Versiti - Bonnie Dittel Laboratory | Versiti Blood Research Institute The Dittel Laboratory investigates cellular and molecular mechanisms involved in the regulation of inflammation, a component of virtually every disease.

Learn more: versiti.org/versiti-bloo...

Elevated frequencies of activated memory B cells in multiple sclerosis are reset to healthy control levels after B cell depletion with Ocrelizumab - PubMed In multiple sclerosis (MS) the B cell depleting drug ocrelizumab has shown high efficacy in reducing inflammatory activity. Its mechanism of action is unclear due to B cell subset complexity and unkno...

Check out publication by VBRI Senior investigator Bonnie Dittel and collaborators
pubmed.ncbi.nlm.nih.gov/39643951/

Versiti - Alan E. Mast, MD, PhD | Versiti Blood Research Institute Dr. Mast is the Walter Schroeder Endowed Chair for Blood Research and a senior investigator at Versiti Blood Research Institute.

Learn more: versiti.org/versiti-bloo...

The roadmap to integrate diversity, equity, and inclusion in hematology clinical trials: an American Society of Hematology initiative - PubMed Clinical trial design for classical hematologic diseases is difficult because samples sizes are often small and not representative of the disease population. The American Society of Hematology initiat...

Check out publication by VBRI Senior Investigator and Program Co-Leader Alan Mast and collaborators
pubmed.ncbi.nlm.nih.gov/39652409/

Versiti - Lisa Baumann Kreuziger, MD, MS | Versiti Blood Research Institute Dr. Baumann Kreuziger is a medical director of hematology and investigator at Versiti Blood Research Institute who specializes in non-malignant hematology.

Learn more: versiti.org/our-experts/...

Lack of Standardized Coding Limits Accuracy of Electronic Clinical Quality Measure for Pulmonary Embolism Diagnosis - PubMed Guidelines for diagnosing pulmonary embolism (PE) start with a risk assessment using a pretest probability (PTP) tool, followed by D-dimer testing or computed tomography pulmonary angiography (CTPA) d...

Check out publication by VBRI Senior Medical Director, Investigator Lisa Baumann Kreuziger and collaborators
pubmed.ncbi.nlm.nih.gov/39930618/

Versiti - Tirthadipa Pradhan-Sundd, PhD | Versiti Blood Research Institute Tirthadipa Pradhan-Sundd, PhD is an associate investigator at Versiti Blood Research Institute, whose research focuses on Transfusion Medicine, Vascular Biology and Cell Therapy.

Learn more: versiti.org/versiti-bloo...

Heme-Oxygenase 1 Mediated Activation of Cyp3A11 Protects Against Non-Steroidal Pain Analgesics Induced Acute Liver Damage in Sickle Cell Disease Mice - PubMed Pain constitutes a significant comorbidity associated with sickle cell disease (SCD). Analgesics serve as the primary method for pain management; however, the long-term effects of these drugs on the l...

Check out publication by VBRI Associate investigator Dipa Pradhan-Sundd and collaborators
pubmed.ncbi.nlm.nih.gov/39936985/

Versiti - Yiliang Chen, MBBS, PhD | Versiti Blood Research Institute Dr. Chen is an assistant investigator at Versiti Blood Research Institute, whose research focuses on atherosclerosis and its underlying mechanisms.

Learn more: versiti.org/versiti-bloo...

Angiotensin 1-7 and a TERT activator individually restore vasodilatory capacity within the microcirculation previous SARS-CoV-2 infection - PubMed Angiotensin 1-7 and a TERT activator individually restore vasodilatory capacity within the microcirculation previous SARS-CoV-2 infection

Check out publication by VBRI Associate investigator Yiliang Chen and collaborators
pubmed.ncbi.nlm.nih.gov/39943809/

Versiti - Joshua Muia, PhD | Versiti Blood Research Institute Joshua Muia, PhD is an associate investigator at Versiti Blood Research Institute, whose research focuses on structural and functional studies of ADAMTS13, vascular biology, and coronary artery diseas...

Learn more: versiti.org/versiti-bloo...

Arginine Methylation by PRMT1 Affects ADAMTS13 Secretion and Enzymatic Activity - PubMed These results demonstrate the crucial role of arginine methylation on ADAMTS13 secretion and activity. Our findings may shed new light on the mechanism of allosteric regulation of ADAMTS13, which may ...

Check out publication by VBRI Associate investigator Joshua Muia and collaborators
pubmed.ncbi.nlm.nih.gov/39945068/

Versiti - Thomas Abshire, MD | Versiti Blood Research Institute Senior Investigator Emeritus Thomas Abshire, MD, studied the evaluation of mild bleeding disorders and clinical trials in Von Willebrand disease (VWD).

Learn more: versiti.org/our-experts/...

Duration of anticoagulation for venous thromboembolism in pediatric patients: Evaluation of the Duration of Therapy for Thrombosis in Children (Kids-DOTT) trial outcomes at 2 years - PubMed These findings support durability of the Kids-DOTT randomized clinical trial findings of net clinical benefit at 2 years.

Check out publication by VBRI Senior Investigator Emeritus Thomas Abshire and collaborators
pubmed.ncbi.nlm.nih.gov/39461724/

Versiti - Alan E. Mast, MD, PhD | Versiti Blood Research Institute Dr. Mast is the Walter Schroeder Endowed Chair for Blood Research and a senior investigator at Versiti Blood Research Institute.

Learn more: versiti.org/versiti-bloo...

Examining downstream effects of concizumab in hemophilia A with a mathematical modeling approach - PubMed The effectiveness of concizumab is mediated through the blockade of TFPI anticoagulant activities in plasma and on multiple physiological surfaces. An important and previously unrecognized function of...

Check out publication by VBRI Senior Investigator and Program Co-Leader Alan Mast and collaborators
pubmed.ncbi.nlm.nih.gov/39536817/

Versiti - Jieqing Zhu, PhD | Versiti Blood Research Institute Dr. Zhu is an investigator at Versiti Blood Research Institute who focuses on understanding cell surface receptors and how they transmit signals.

Learn more: versiti.org/versiti-bloo...

Borrelia burgdorferi tolerates alteration to P66 porin function in a murine infectivity model - PubMed <span><i>Borrelia burgdorferi</i> exists in a complex enzootic life cycle requiring differential gene regulation. P66, a porin and adhesin, is upregulated and essential during mammalian infection, but...

Check out publication by VBRI Senior investigator Jieqing Zhu and collaborators in
pubmed.ncbi.nlm.nih.gov/39906208/