Matt Doyle

Congrats to #USYD's A/Prof Yu Heng Lau for landing a $958,564 ARC Discovery grant to develop tiny protein cages to improve how plants use carbon, water & nutrients + boost crop yields. Sydney Analytical + Sydney Mass Spectrometry look forward to continuing our collaboration.
@yuhenglau.bsky.social

This strain has lost its virulence plasmid (presuming Congo red velvet)

The scientific process #science

Text reads “Antibiotic resistance is rising,” with an upward arrow and a “40%” warning icon. Below, a text box says: “Between 2018 and 2023, resistance increased in over 40% of the monitored pathogen–antibiotic combinations, with an annual rise of 5–15%.”

Between 2018–2023, antibiotic resistance increased in over 40% of the pathogen–antibiotic combinations monitored, with an average annual rise of 5–15%.

Resistance is highest in the WHO South-East Asian & Eastern Mediterranean Regions, where 1 in 3 reported infections were resistant 👉 bit.ly/438Ta1u

This is super

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.

Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social

We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.

doi.org/10.1038/s415...

You guys did great organising. My folks loved the venue being UQ.

Thanks for coming Doyle lab! It was great to have you here.

Congratulations to all our poster and speaker prize winners!! 🏆🏆🏆

And that's a wrap! A huge shout out goes to our conference chair Michael Landsberg @dr-berger.bsky.social and the rest of the organizing committee for putting together such a vibrant #ASBMB2025! See you all at #ComBio2026!

Thanking support from @asbmbaus.bsky.social for travel award to Alanah, @sydney.edu.au for travel support for Alfred, and Sydney Infectious Diseases Institute and the Centre for Drug Discovery Innovation for supporting their research.

Very proud of both my students @itzfredz.bsky.social (Alfred Hartojo) and @alanaheisenhuth.bsky.social (Alanah Eisenhuth) for presenting their research at ASBMB2025. Also congrats to Alfred for his poster prize! 👏🏆

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

This is an amazing paper led by the Grinter lab on bacterial protein antibiotics called pyocins and the mechanism by which they inhibit the BAM outer membrane complex. @rhyswg.bsky.social, @knottrna.bsky.social, @debnathghosal.bsky.social, @doylemt1.bsky.social, @fabianmunder.bsky.social

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬

PINK1 Parkinson's Disease Research Team @wehi-research.bsky.social is a finalist in the @unsw.edu.au Eureka Prize for Scientific Research.

Learn more: youtu.be/senXARXzO20

#EurekaPrizes @komanderlab.bsky.social @zhongyangan.bsky.social @sylviecallegari.bsky.social @nskirk.bsky.social

“Revolutionary Science Comes from Unexpected Angles”

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve.

Preprint 📝: biorxiv.org/content/10.1...

🧵 1/n

Introducing Latent-X — our all-atom frontier AI model for protein binder design.

State-of-the-art lab performance, widely accessible via the Latent Labs Platform.

Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X

Forecasting the Fallout from AMR: Economic Impacts of Antimicrobial Resistance in Humans Antimicrobial resistance (AMR) is a growing global health crisis that threatens to undo decades of progress in medicine. This tool allows you to explore the potential impact of different interventions...

The costs of #antimicrobial resistance 🦠 continue to rise 📈. The Center for Global Development reports that by 2050 #AMR could shrink the global economy by US$1.7T.
Improving treatments and funding development of new antimicrobials 💊 could save millions of lives and billions in healthcare costs.

Unfortunately I have to skip this one because I'm at ASM. Break a leg @rhyswg.bsky.social !

Excited to be in Adelaide for the MTPconnect Innovation in Antimicrobials event ahead of attending 2025 ASM Conference @aussocmic.bsky.social

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...

Check out these amazing lipid-monolayer-trapping oligomeric OMPs published by @lalouxlab.bsky.social and Lovering Labs. The BAM complex in these bugs must be wild!

www.nature.com/articles/s41...

Lost in the labyrinth of poorly LLM written "scientific" articles. Bad science writing example excerpt:

"Initially, we delve into the intricacies of […], accentuating its indispensability in cellular physiology, the enzymatic labyrinth governing its flux, and the pivotal […] mechanisms."

...boy

PhD Scholarships at Monash University - MACSYS Do cutting-edge research at the frontiers of Whole Cell Modelling! The MACSYS Node at Monash University has multiple PhD Scholarships available to work on some exciting projects! $41,753 p.a. stipend ...

Great science looks at big unknowns.

In bacteria, sRNAs control gene expression but ‘how’ they do this at systems level is far from known. @MACSYS is recruiting for courageous PhD students who would learn, know and report how sRNAs deliver systems level phenotypes

macsys.org/monash-phd-s... for

Cryo-EM structures of the E. coli Ton and Tol motor complexes - Nature Communications The Ton and Tol systems are bacterial energy-transducing complexes that use the proton motive force at the inner membrane to exert force on outer membrane proteins. Here the authors present the high-r...

After an unexpectedly long editorial process, our paper describing the structures of the E coli TolAQR and TonB-ExbBD complexes is finally out. The coordinates are to be released on July 9th on the PDB.

www.nature.com/articles/s41...

It is a very short list of cities in which you can visit three world class research universities on three consecutive days without switching hotels.

Tomorrow, Sydney University. Wednesday, UNSW. Thursday, Macquarie University.

Feeling very humbled by receiving this award and equally excited to attend ASM in Adelaide this year! 🎉

JAMS June Monthly is next week🥳

📅 Tuesday 24th June, 2024
📍 The Rose, Chippendale (LOCATION CHANGE!)

Can't wait to see you all at this new location! Come for the microbes, stay for the mates 🍻

#microbiolgy #JAMSmicro #science #seminar #networking #biology #research

@doylemt1.bsky.social

Super excited to share our latest work revealing impt of protein-lipid interactions for the pri fn of the Tol-Pal complex in maintaining outer memb lipid homeostasis in E. coli! Huge discovery by Nadege Lim in collab @pstansfeld.bsky.social @robincorey.bsky.social 1/7
www.biorxiv.org/content/10.1...