Daniel Bachurski

Isolation shapes identity.

📣 Our new paper is out in Advanced Healthcare Materials:

advanced.onlinelibrary.wiley.com/doi/10.1002/...

EV isolation defines functional identity.
Checklist compliance is not enough — function matters.

#ExtracellularVesicles #IsolationMatters #EVresearch

Small intracellular vesicles outperform small extracellular vesicles in uptake, drug delivery and retinal neuroprotection - Nature Biomedical Engineering A protocol to isolate small intracellular vesicles from human cells is reported; these are molecularly distinct from small extracellular vesicles and show superior therapeutic potential in retinal deg...

We've all heard of EVs for drug delivery, but what about intracellular vesicles?

Small intracellular vesicles outperform small extracellular vesicles in uptake, drug delivery and retinal neuroprotection | Nature Biomedical Engineering share.google/xWrOtYU4ElbJ...

Great news for everyone working on EVs and viruses: the #GFV2026 meeting will include a full session on #ExtracellularVesicles in Viral Infection! Looking forward to the discussions and abstracts from our communities.
📅 17–20 March 2026, Heidelberg
📝 Abstracts: 4 Jan 2026
🔗 virology-meeting.de

New graphical review out now from our Biology of B-cell Malignancies special issue

📕 Biological and technical complexities in analyzing extracellular vesicle immune interactions in B-cell malignancies

✍️ @danielbachurski.bsky.social & Michael Hallek

🔗 febs.onlinelibrary.wiley.com/doi/10.1002/...

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

Single recipient cell tracking of tellurium-labeled extracellular vesicle proteomes (TeLEV) identifies EV-driven immunomodulation Extracellular vesicles (EVs) mediate tumor-immune cell communication by carrying protein cargo that can immediately modulate signaling and antigen presentation. Yet mapping the uptake of primary EV pr...

Excited to share that TeLEV is now live! Our preprint introduces a new method to track #extracellularvesicle (EV) proteomes in single cells using advanced techniques. TeLEV reveals insights into an interleukin receptor triad and immune remodeling. Huge thanks to all collaborators! Preprint here:

Our illustration of immune cell-derived #extracellularvesicles (EVs) in B-cell malignancies is on the cover of FEBS Letters' "Biology of B-cell Malignancies".

We discuss how novel techniques enhance understanding of cell communication in the tumor-immune environment. doi.org/10.1002/1873...

Sswsesessssas

🔬 Extracellular vesicles shape immune crosstalk in B-cell malignancies—but remain elusive. Explore the latest insights from new single-EV & single-cell tools: febs.onlinelibrary.wiley.com/doi/10.1002/...
#EVs #CancerResearch #BCellLymphoma @danielbachurski.bsky.social

Editorial - A stronger Europe starts with science As leaders from industry, policy and science gathered in Brussels for a lively exchange this spring, o

“Europe’s success depends on treating #science and #research as tools for competitiveness and on recognising them as foundational to Europe’s long-term strategy” erc.europa.eu/news-events/... @erc.europa.eu

Thank you a lot, @broeckelmann.bsky.social, for your support and collaboration

FEBS Press Click on the article title to read more.

In recent years, we have developed tools to gain deeper insights into #extracellularvesicle immune cell interactions in B-cell malignancies. We have learned a lot and want to share our perspective: doi.org/10.1002/1873...

Extracellular exosomal RNAs are glyco-modified - Nature Cell Biology Sharma, Jiao and colleagues report glycosylation of small RNAs within exosomes and propose a glycosylation-dependent mechanism for RNA targeting into exosomes, which may influence intercellular commun...

More insights into #glycoRNA, this time found within exosomes!

www.nature.com/articles/s41...

GSEV POST-ISEV 2025 webinar
2 Jun 2025 · 15:00 CEST · Zoom

Recap of #ISEV2025 with Eva-Maria Krämer-Albers, Allegra Angenendt, Lisa Wessendorf, Fanni Borros + wrap-up team.

Register ➜ fau.zoom-x.de/webinar/regi...

#GSEV #EVresearch #extracellularvesicles

Inhibition of acid or neutral sphingomyelinases differentially impacts RNA and protein cargo sorting to extracellular vesicles Extracellular vesicles (EVs) form through regulated biogenesis processes involving sphingomyelinases (SMases), enzymes that metabolize sphingomyelin t…

Pretty cool study showing the effect of acid sphingomyelinase on non-coding RNA cargo of MCF-7 EVs.
Big changes in 'miscRNAs' 7SL and Y3 RNA, and functional effects in wound healing
www.sciencedirect.com/science/arti...

Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis | NEJM Semaglutide, a glucagon-like peptide-1 receptor agonist, is a candidate for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). In this ongoing phase 3, multicenter, randomize...

New @nejm.org
Another win for semaglutide (Ozempic) and the GLP-1 drugs: reduction of liver fibrosis in MASH
www.nejm.org/doi/full/10....

Thank you a lot, Christian! Also for highlighting our collaboration 😊

Thank you very much @genequan.bsky.social 😊

CONGRATULATONS 👏👏👏 #ISEV2025 Poster Prize for Daniel Bachurski from #GSEV

Great to be back!

Off to Vienna for #ISEV2025! Two projects from the Hallek Lab @unicologne.bsky.social:
– #TeLEV single‑cell EV profiling in CLL (Poster 410, Session 1, Apr 24)
– MULTI-TeLEV: Multiplexed EV uptake assay (OS22, Apr 26 14:30)

Excited to co-chair OS22 with @frederikverweij.bsky.social. DM to connect!

👉 Join us for the #GSEV PubQuiz at #ISEV2025 in Vienna!
🗓️ April 26 | 🕕 5:45–7:15 PM | 📍 Room Schubert 4–6
🎯 Fame, glory, free drinks + snacks, and prizes!
🚨 Max 100 spots — first come, first served!
🔗 gsev.org/gsev-pubquiz-at-isev2025/

🚨 Registration & abstract submission now open!
Join us at GSEV 2025, Sept 25–26 in Essen.
🔗 gsev.org/gsev-2025-au...

Topics: EV biogenesis, standardization, cancer, neuro & cardio disease, immunity & more.
Submit abstracts by May 31 (oral) / Jul 31 (poster)

#GSEV2025 #extracellularvesicles

Why should scientists remain apolitical (especially in times like these)?

Hello, Bluesky! ☀️

We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.

Follow us for updates on ERC funding, research policy, and our grantees' discoveries.

Not all tRNA fragments (tDRs) are created equal. Here we share methods to differentiate:

1) real tDRs and those produced by dissociation of nicked tRNAs, 2) nicked tRNAs / tDRs in extracellular vesicles vs outside.

1) www.sciencedirect.com/science/arti...

2) www.sciencedirect.com/science/arti...

B cells in non-lymphoid tissues - Nature Reviews Immunology B cells are major drivers of systemic immunity, but they also act locally in non-lymphoid organs. This Review highlights new insights into mechanisms of tissue B cell function as well as efforts to le...

Review @natrevimmunol.bsky.social @laurenrodda.bsky.social @georgecelis.bsky.social
B cells in non-lymphoid tissues
www.nature.com/articles/s41...

‘Dark proteins’ hiding in our cells could hold clues to cancer and other diseases The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.

"Dark proteins." Also known as microproteins. There are thousands of them in our cells and we're still struggling to define their function. Succinctly reviewed @nature.com www.nature.com/articles/d41...

This rate of validation suggests that antibodies should be considered non-specific until proven otherwise:

357 validated out of 1,124 tested.

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EU medicines agency quits X, moves to Bluesky The European Medicines Agency (EMA) said on Monday it would no longer post on X and would use rival Bluesky instead, becoming the latest organisation to quit a social media platform that some have criticised for its content.

EU medicines agency quits X & moves to Bluesky

"EMA will no longer post updates and content on X. We believe the X platform no longer suits our communication needs” the agency said in a statement

www.reuters.com/world/europe...