@the-asci.org.bsky.social
The ASCI is a nonprofit honor society of physician-scientists. Founded in 1908, the Society is home to 3,500+ members across academic medicine and industry. https://the-asci.org Take action for federal funding of research: https://www.fundresearch.org/
How do leukemia fusion proteins drive malignant transformation?
ASCI member Paul P. Liu & team reveal a mechanism in which increased binding affinity between RUNX1 and its target DNA is a critical for the fusion gene CBFB-MYH11 to induce leukemia in mice: www.jci.org/articles/vie...
A promising drug target for regenerating functional Ξ²-cell mass in diabetes!
ASCI member @sanderlaberlin.bsky.social & team discover the deacetylase SIRT2 restrains proliferation of pancreatic Ξ²-cells in a glucose-dependent manner: www.jci.org/articles/vie...
Personalized treatment in HPV+ oropharynx cancer using genomic adjusted radiation dose
ASCI member @cancerconnector.bsky.social & team analyze gene expression profiles in patients with HPV+ OSCC & provide a model that outperforms standard measures for predicting OS: www.jci.org/articles/vie...
We thought the brain couldnβt use fatty acids or metabolize triglyceride-rich lipoproteins.
ASCI member Stephen G. Young & team now provide convincing evidence for lipoprotein lipase-mediated intravascular triglyceride processing in the CNS: www.jci.org/articles/vie...
ASCI member Quaggin & team now show SGLT2 inhibition increases tissue levels of SAM, resulting in enhanced H3K27 trimethylation & repression of inflammatory genes:
www.jci.org/articles/vie...
How might air pollution contribute to insulin resistance?
ASCI member Sanjay Rajagopalan & team demonstrate exposure to PM2.5 air pollution in mice leads to mitochondrial dysfunction in brown fat & metabolic dysfunction through epigenetic regulation: insight.jci.org/articles/vie...
Progress towards enhancing #cancer immunotherapies in the context of solid tumors!
ASCI member William E. Carson III & team show BRD4 inhibition can reduce suppressive immune cells in murine cancer models: www.jci.org/articles/vie...
Update: The Early-Career Award (YPSA/E-Gen) deadline has been extended to October 21
06.10.2025 15:27 β π 0 π 0 π¬ 0 π 0
A major barrier to HIV cure is a population of T cells that harbors replication-competent proviruses
Here, ASCI member Robert F. Siliciano & team report most viruses in the latent HIV-1 reservoir are resistant to autologous neutralizing antibodies: www.jci.org/articles/vie...
T cell engagers are effective in treating myeloma, but dosing schedules have not been defined.
In this research letter, ASCI member Madhav V. Dhodapkar & team find in vivo CD4+ T cell fitness within 48 hours following TCE therapy correlates with outcomes: www.jci.org/articles/vie...
Maybe you didnβt hearβthis molecule is silencing oncogenes
ASCI member Chad V. Pecot & team developed an inverted RNAi molecule that enhances dual silencing of KRAS and MYC in cancer models: buff.ly/xzjBnEL
On a FOX hunt in severe autoimmunity
ASCI member Jonathan S. Maltzman & team explore the functional interactions among FOXP family members in regulatory T cells, revealing loss of Foxp1 & Foxp4 in Tregs from mice causes systemic inflammation and premature lethality: buff.ly/4kzMQe0
Emerging roles for complement in lung transplantation
As part of JCIβs Review series on complement biology and therapeutics, ASCI member Hrishikesh S. Kulkarni et al. explore complement activation and strategies for inhibition in the lung transplant process: buff.ly/UXQWFKq
ATTN: Medical School Deans! The ASCI PSSF Fellowship Nominations are open.
Our immersive, mentored, gap-year opportunity is for MD-only medical students.
MS Deanβs nomination deadline: 10/13/25
Final application deadline: 1/6/26
Contact: programs@the-asci.org
Details: buff.ly/O4zWRl1
Irregular heartbeat is a common complication after surgery.
In this research letter, ASCI member Xander H.T. Wehrens & team reveal a factor derived from atrial fibroblastsβMIFβnecessary for atrial macrophage recruitment and post-operative AFib: buff.ly/PL8GnGT
An open letter to the NIH: Value and costs in publishing
Here we share our response to the NIHβs request for information on maximizing research funds by limiting allowable publishing costs: buff.ly/K6hbsA4
#AcademicPublishing #ScholarlyPublishing #OpenAccess
@scholarlykitchen.bsky.social
Acute kidney injury increases the risk for long-term kidney dysfunction.
Here, ASCI member Chirag R. Parikh & team identify urine proteins in pathways of degenerative tubular cell injury, inflammation & fibrosis associated with long-term eGFR decline after hospitalization with AKI: buff.ly/6xqmTk5
Can we root out the seeds of metastasis?
ASCI member Huiping Liu & team identify a rare T cell subset that cluster circulating tumor cells to promote metastasis in breast cancer, then provide a proof-of-concept block using VLA-4 antibody in preclinical models: buff.ly/o5N4RMr
Classical type 1 dendritic cells have roles in immunoregulation, but their involvement in organ transplant was unclear.
ASCI member Kory J. Lavine & team reveal cDC1s expand after costimulation blockade & are essential for long-term cardiac allograft acceptance in mice:
buff.ly/VECueEr
Can we drive anti-tumor immunity in advanced prostate and ovarian cancers?
ASCI member Arul M. Chinnaiyan & team find pharmacologic degradation of CDK12/13 delays tumor growth and improves ICB response in several cancer models: buff.ly/SDFvlox
Getting a grip on TSH-resistant hypothyroidism
ASCI member Peter Arvan & team reveal thyroidal expression of ER molecular chaperone GRP170 is required for efficient TSH-mediated thyroid hormone synthesis: buff.ly/fhwpCeK
Erythropoietic protoporphyria causes phototoxicity and can also involve the liver due to protoporphyrin IX accumulation in red blood cells.
ASCI member Mark D. Fleming & team find bitopertin reduces PPIX accumulation and mitigates liver disease in EPP models: buff.ly/9TuVOy3
Somatic mutations are surprisingly widespread in most tissues, and some may protect against disease.
ASCI member @haozhulab.bsky.social & team now reveal TBX3 somatic mutations in the liver influence metabolic dysfunction-associated steatotic liver disease
(#MASLD): buff.ly/Ob2JxYY
Could metformin reduce structural heart disease?
ASCI member Chinmay M. Trivedi & team find epigenetic changes in nuclear DNA aberrantly activate mitochondria, causing aortic valve stenosis, with improvement by metformin in mice:
buff.ly/rmQsCU0
Current dogma posits IFN-Ξ³ and CD8+ T cells have anti-tumor roles.
Now, ASCI member Alexander Sasha Krupnick & team examine multiple lung adenocarcinoma models and discover IFN-Ξ³ derived from lung cancer cells can, in fact, promote tumor growth via CD8+ T cell chemokines: buff.ly/mEVwWHy
A vaccine for Pseudomonas has eluded researchers for decades
ASCI member @nizet.bsky.social & team now provide a different vaccination approach, demonstrating an engineered nanoparticle vaccine protects mice against lethal pneumonia.
Full report: buff.ly/Ipwj7gT
People with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares.
In this research letter, ASCI member Johann E. Gudjonsson & team show spesolimab treatment helps control the inflammation and prevent future flares.
buff.ly/cYw1WJG
Cancer can activate the coagulation system, but how do anticoagulants affect checkpoint therapy?
ASCI member Wolfram Ruf & team show coagulation signaling subverts the tumor-DNA immune response & anticoagulants with ICB synergistically reduce tumor growth in mice.
buff.ly/jyIQNvz
Could blocking FSH hormone prevent osteoporosis, obesity, and Alzheimerβs disease?
In this issue, ASCI member Mone Zaidi & team develop a humanized FSH-blocking antibody that reduces obesity and rescues memory & learning loss in preclinical models.
See full report: buff.ly/c6XYm3p
Understanding the STING in autoimmunity!
ASCI member Anthony Shum & team investigate mouse models of the immune dysregulation disorder COPA syndrome and show STING activation in thymic epithelial cells has a role in shaping the T cell repertoire and promoting autoimmunity:
buff.ly/l8QUW0D
