Klebanoff Lab

Excited to announce a new paper in ‪@aacrjournals.bsky.social‬ with Junwei Shi and Tony Daniyan. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in a variety of hematologic malignancies:
aacrjournals.org/cancerdiscov...

12.08.2025 17:09 — 👍 14    🔁 5    💬 1    📌 0

CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit - Nature Cancer Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS signaling enhances their an...

📢New Article published at Nature Cancer!

✒️By Christopher Klebanoff and colleagues

'CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit'

🔗 www.nature.com/articles/s43...

30.07.2025 11:51 — 👍 5    🔁 1    💬 0    📌 0

Cellular Immunotherapies Carry Seeds of Self-Destruction but Can Be Rescued With Genetic Engineering Read about a new discovery that could lead to more powerful cell-based therapies for cancer.

MSK’s @klebanofflab.bsky.social and team found that FAS ligand, which hampers #CAR-T and #CAR-NK therapies, is actually produced by immune cells themselves.

28.07.2025 15:07 — 👍 11    🔁 2    💬 1    📌 0

Complete tumor eradication with cell therapies depends on persistence of donor CAR-cells in the patient
@klebanofflab.bsky.social show that deletion of Fas on donor CAR-T/CAR-NK improves persistence in FasL-dependent (host NK & T) manner @natcancer.nature.com
www.nature.com/articles/s43...

24.07.2025 20:27 — 👍 6    🔁 1    💬 2    📌 0

CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit Nature Cancer - Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS...

🚨Today, in #NatureCancer, we show that #CAR-T cells and #CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy. @mskcancercenter.bsky.social @parkerici.bsky.social

23.07.2025 20:39 — 👍 13    🔁 9    💬 0    📌 0

🙌🎉🙌

04.06.2025 23:22 — 👍 0    🔁 0    💬 0    📌 0

MSK physician-scientist Dr. Christopher Klebanoff talked about all things #neoantigens for the Novel Classes of Human Cancer Rejection Antigens session this morning at #AACR25.

29.04.2025 16:58 — 👍 7    🔁 2    💬 0    📌 0

This is part of a long-standing collaboration with Rob Bradley’s lab
‪@fredhutch.bsky.social‬ and with amazing TCR discovery expertise from Chris Klebanoff’s lab @klebanofflab.bsky.social @mskcancercenter.bsky.social‬‬. Also incredible help from Jeff Molldrem @mdanderson.bsky.social‬‬‬‬‬

23.04.2025 20:30 — 👍 4    🔁 1    💬 1    📌 0