Estefania Sanchez-Vasquez

Estefania Sanchez-Vasquez

@niasv.bsky.social

NICHD T32 fellow HSRU postdoctoral fellow Pew Latin American fellow Development & Stem cell bio ‍🌈 UNMSM 🇵🇪 UNSAM 🇦🇷 UCSC/Caltech 🇺🇸

595 Followers 1,807 Following 106 Posts Joined Nov 2024
17 hours ago
from random data to a story, using legos

🌐🧪

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Our #CellLineOfTheWeek is beta-actin - illuminating actin filaments! 🧫

Our entire catalog of stem cell lines & plasmids are available to researchers for just the cost of shipping to reduce the barriers to discovery

📦 Distributed by @Coriell_Science and @Addgene

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New preprint! Our workflow for processing single cell and nuclei data, called 🎉 scprocess 🎉 We have been working on it for ~18 months now, over which time we have processed at least 2k samples with it, so it has had a decent amount of testing.

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Our cover image for the March issue is up!
Check out the issue here: www.sciencedirect.com/journal/cell...

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Stem Cell & Developmental Biology Early Career Symposium
September 23-25, 2026
Allen Institute, Seattle, WA
Apply to attend today! Applications close May 1
QR Code to symposium website: https://alleninstitute.org/events/stem-cell-developmental-biology-early-career-symposium/
Allen Institute logo; International Society for Stem Cell Research logo; Society for Developmental Biology logo

Applications open for the Stem Cell & Developmental Biology Early Career Symposium being held September 23-25, 2026 in Seattle, WA. This joint symposium is a collaboration between @alleninstitute.org, @isscr.org and @socdevbio.bsky.social Application Deadline: May 1. bit.ly/4p98dkv

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✨Development from the tail up 🦎 Gecko embryo tail glowing with HNK1 🟢 and DAPI 🔵 under the microscope 🔬 Proof that even the tail end of an embryo can be fabulous. 📸 Image by Maria Elena de Ballard #FluorescenceFriday

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A solar flare erupting on a glass coverslip ☀️🔬

This mouse cell has broken symmetry, erupting to drive itself across the surface.

🧡 Actin: Sweeping golden kinetic energy
🩵 Septin 7: Swirling membrane regulation
🩷 Lipids: Burning metabolic fuel
💙 DNA: The anchored core

#SciArt #FluorescenceFriday

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Prolonged starvation deepens quiescence in Vasa2/Piwi1-expressing cells of a sea anemone Animals with lifelong growth modulate cell proliferation in response to nutrient availability, but the underlying mechanisms are not fully understood. This study shows that starvation induces a revers...

💡How does nutrition regulate cell cycle in stem cells? Check out our new paper from @prhsteinmetz.bsky.social lab & @msarscentre.bsky.social, out now in
@plosbiology.org (plos.io/48J2o6P)
#SeaAnemone #Nematostella #StemCell #CellCycle #Quiescence #TORsignalling 1/12

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A split-image composition featuring two historical photographs side by side, highlighting Maria Reiche and one of the famous Nazca Lines geoglyphs she dedicated her life to studying.

Left side: A black-and-white portrait of Maria Reiche, the renowned German-born Peruvian mathematician and archaeologist (1903–1998), known as the "Lady of the Lines." She appears as a woman in her later years, with a serious and determined expression, wearing round wire-rimmed glasses, a light-colored headscarf, and a simple button-up shirt or work blouse with short sleeves. A camera or binoculars hangs from a strap around her neck, resting against her chest as she holds it in her hands. 

Right side: An aerial black-and-white view of the Nazca Lines' iconic hummingbird geoglyph etched into the arid Pampa Colorada desert near Nazca, Peru. The large biomorphic figure, created by removing the darker surface pebbles to reveal lighter soil beneath, depicts a stylized hummingbird in profile with an elongated beak pointing right, a rounded head, detailed eye, outstretched wings formed by parallel straight lines, a compact body, and a fanned tail. The lines are precise and continuous, measuring over 90 meters (about 300 feet) in length, surrounded by faint straight lines and trapezoids typical of the ancient Nazca culture's vast network of geoglyphs visible only from the air.

This diptych juxtaposes the dedicated researcher with one of the enigmatic ancient artworks she meticulously mapped, preserved, and brought to global attention through decades of on-site work starting in the 1940s.

Maria Reiche (1903–1998) was a mathematician & archaeologist who dedicated >50 yrs of her life to the study & preservation of the Nazca Lines in Peru.

The "Lady of the Lines" is credited with bringing these ancient geoglyphs to international attention & ensuring their protection. #WomenInSTEM #WHM

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Gene expression patterns in zebrafish embryos (6-somite stage; anterior at top).

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A new mechanism for “RNA memory”! This time in Planaria! (Here's a video of a Planarian with mulitple heads, one of the heritable phenotypes we studied).

This work summarizes >10 years of research and is an amazing collaboration with the labs of Jochen Rink and Omri Wurtzel labs. Read thrad below👇

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Gisela Cairo @giselacairobaza.bsky.social, Muhammad Haseeb @muhammad-haseeb.bsky.social, Soni Lacefield @lacefieldlab.bsky.social & team find that the MOS-MAPK pathway regulates polar body fate in mouse oocytes.
journals.biologists.com/jcs/article/...

journals.biologists.com/jcs/article/...

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Review @jem.org
Myeloid diversity in tumors: Shaped by genes, location, and time
rupress.org/jem/article/...

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napari 0.7.0 ⚠️ Note: these release notes are still in draft while 0.7.0 is in release candidate testing. ⚠️ Tue, Mar 10, 2026 We’re happy to announce the release of napari 0.7.0! napari is a fast, interactive,…

Check out and give feedback on the latest pre-release 0.7.0rc0! You can install with `pip install "napari[all]>=0.7.0rc0"` or via the bundled app. 😁 🥳

The release notes, with highlights, include so many great new features and changes: napari.org/dev/release/...

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For those interested! More details here: www.grc.org/visual-syste... #ZebrafishMeeting

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Spider-like neurons finding their way: signposts for multipolar migration in the developing brain - FocalPlane Spider-like neurons finding their way: signposts for multipolar migration in the developing brain - News

📢New behind the paper story

Using the #zebrafish retina as a model, Jaakko Lehtimäki
@jalehtimaki.bsky.social, Caren Norden
@nordenlab.bsky.social & team dissect multipolar migration in the developing brain. In this post, Jaakko takes us through their research.

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🐟 We are hiring a postdoc!
Interested in RNA regulation, gene expression, and zebrafish embryogenesis? Join the Bazzini Lab at @stowersinstitute.bsky.social
www.stowers.org/labs/bazzini...
Please share! Details below 👇
#Postdoc #RNAbiology #zebrafish #devbio #Genomics

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Society for Developmental Biology Ethel Browne Harvey Postdoctoral Seminar Series
Friday, March 13, 2026, 3:00pm - 4:00 pm Eastern Time
Martha Echevarría-Andino (University of Wisconsin-Madison)
Hoxa11/Hoxd11 transcription factors regulate extracellular matrix genes during osteochondral differentiation
M. Fernanda Palominos (University of California, Berkeley)
Novel craniofacial genes linked to extreme jaw evolution in pupfishes revealed by tissue-specific transcriptomics and speciation genomics

The next the Ethel Browne Harvey Postdoc Seminar will be held this Friday, March 13 at 3 pm Eastern Time with Martha Echevarría-Andino @uwmadison.bsky.social and M. Fernanda Palominos @ucberkeleyofficial.bsky.social. Register today and join us. bit.ly/47QVIEK #SDBPostdocSeminar

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Gene regulatory networks: from correlative models to causal explanations - Nature Reviews Genetics In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without compromising explanatory power.

"GRNs, which should provide mechanistic explanations, are increasingly reduced to statistical correlations — ‘hairballs’ that fail to capture molecular causation"

By Maizels and @jamesbriscoe.bsky.social

www.nature.com/articles/s41...

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Please check out our new preprint! Using single cell analysis paired with HCR to visualize transcript localization we have identified cell and tissue-specific expression of various genes encoding tubulins, kifs, and dyneins during neural crest development!

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Call for Papers! Submit to the Splicing in Development and Disease special issue

Deadline extended: Submit your research on splicing in development and disease to the Differentiation special issue led by Guest Editors Natoya Peart and Karine Choquet by June 30, 2026. Learn more: https://www.sciencedirect.com/special-issue/322731/splicing-in-development-and-disease

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Imaging spotlight: Altair-LSFM - FocalPlane Imaging spotlight: Altair-LSFM - News

🔬🔦In this Imaging spotlight, Kevin Dean @kevin-dean.bsky.social and team tell us about their motivation for designing Altair-LSFM, describe its key features, how to setup and use the system and their planned developments.
focalplane.biologists.com/2026/03/09/i...

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RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...

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First 24 hours of embryonic development in 9 different animal species: (From left to right) Zebrafish, Sea urchin, Black widow spider, Tardigrade, Sea squirt, Comb jelly, Parchment tube worm, Roundworm, Slipper snail. Credit to @tessamontague.bsky.social & Zuzka Vavrušová. #ZebrafishZunday #devbio 🧪

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Colorful comparison of different zygote sizes from the minuscule C. elegans (50 micrometers) to the massive chick zygote (30k micrometers). Credit to Prof. Richard Behringer.

To give people a sense of the scale of these videos, check out this comparison of zygote sizes created by @rrbehringer.bsky.social 🧪 #devbio

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Cells use proteins like morphogens to talk to each other in order to build and maintain 3D tissue structures. But how do these morphogens reach distant cells when they are all packed together? We think long #cytonemes play a big role in shaping how cells talk to one another for growth.

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#Dros26 Day 2

What antibodies do you wish we had? Comment below your antibody wishlist!

📸 Drosophila egg chamber labeled with DSHB anti-hts in yellow
🧫 dshb.biology.uiowa.edu/hts-RC

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Confocal micrograph of a mouse embryonic fibroblast with membrane labeled in blue, nuclei in yellow and cellular cytoplasm in red.

Happy #FluorescenceFriday! Here is a mouse fibroblast with multiple thin membrane extensions reaching out toward its neighbors. The long (>10 um) extensions are a type of signaling filopodia called #cytonemes that transport signals like SHH, WNT, Notch, and GFs! 🔬 by Senior Scientist Hong Lin. 🧪 👩‍🔬

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Two complementary articles from the lab of Anming Meng and Katie McDole discussing the history and biology of organizer in 🐟, 🐸, and 🐭. Even after more than 100 years since its discovery, major questions remain, especially for mammals.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...

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How early pregnancy impacts aging: implications for breast-cancer risk New study by UC Santa Cruz team discovers that early pregnancy in mice reduces buildup of ‘confused’ cells that could lead to breast cancer later in life

For #WomensHistoryMonth we spotlight Prof. Shaheen Sikandar. Her research shows how early pregnancy may protect against breast cancer by blocking age-related cell changes. A new @americancancersoc.bsky.social grant will allow her to shift focus from cure to prevention.

news.ucsc.edu/2026/01/preg...

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