Eric Van Nostrand Lab @ BCM

Some cool work with the www.daughertylab.org at UCSD is up! Started by looking at how IFIT2/3 inhibit VSV infection, wound up uncovering a new mechanism for translation inhibition of mRNAs with short 5'UTRs pubmed.ncbi.nlm.nih.gov/41093992

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...

Great work led by @maureenakinyi.bsky.social and Wenjie, with key help from multiple folks here & the Kurian lab (particularly Jakub, Clara, and Deniz)

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

Excited to share some new work from our group - www.biorxiv.org/content/10.1...

A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS

With pending NIH support, we also anticipate having at least 20 travel awards for trainees to attend – more details on that to follow soon

-Eric, @ruggerolab.bsky.social , Anna, Ly, Esther, & Gene

We’ve got a good mix of exciting talks on various aspects of how RNA biology both influences and is controlled by tumorigenesis, and we’d love to have more folks join our effort to continue cross-pollinating these exciting fields! Abstract deadline is Aug 25th

If you’re interested in the interplay between regulation (or mis-regulation) of RNA processing and cancer, please check out the 2025 FASEB RNA Processing in Cancer meeting Oct 5-9 2025 in Sacramento CA!
events.faseb.org/event/RNA-Pr...

From our lab, Joey will be presenting her snoRNA work in Concurrent session 5 (5/28 afternoon), and Maureen & Jen-Yun have posters on Wed evening

Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!

Looking forward to seeing everyone at the @rnasociety.bsky.social meeting!

Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP - Genome Biology Background Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and...

Happy to say our paper with the Whipple lab on snoRNA target profiling with chimeric eCLIP is now out! Great work by co-first authors Joey & Min with the help of a bunch of other folks!

genomebiology.biomedcentral.com/articles/10....

Add please! Thanks!

Mapping snoRNA-target RNA interactions in an RNA binding protein-dependent manner with chimeric eCLIP Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and spliceosom...

(re-post) Happy to share that our preprint on using chimeric eCLIP to map snoRNA interactions (and find new non-canonical snoRNA:RBP subnetworks) is now up! A fun co-collaboration with the great @LabWhipple lab, and great work by Joey, Min, and others!

www.biorxiv.org/content/10.1...

Good to be here!