100 mg/kg melatonin achieved better results than 50 mg/kg in suppressing aggressive Ehrlich ascites carcinoma in mice. The question is, how much is a 100 mg/kg mouse dose for a 65kg human?
Answer: 4600 mg (with adjustment for body surface area, metabolic rate, bioavailability, and administration).

17.06.2025 17:35 — 👍 4    🔁 1    💬 0    📌 0

Why do cancer cells develop resistance to chemo drugs like doxorubicin?

Doxorubicin interacts with the tumor suppressor gene p53 (wildtype and mutants) to cause phase separation and accelerated aggregation, leading to increased survival and proliferation.

pubmed.ncbi.nlm.nih.gov/38435052/

27.05.2025 14:45 — 👍 1    🔁 0    💬 0    📌 0

www.frontiersin.org/journals/pai...

17.05.2025 21:20 — 👍 0    🔁 0    💬 0    📌 0

RUNX2 Phase Separation Mediates Long‐Range Regulation Between Osteoporosis‐Susceptibility Variant and XCR1 to Promote Osteoblast Differentiation A GWAS intergenic SNP (rs4683184) acts as an enhancer, altering the binding affinity of the transcription factor RUNX2 and resulting in changes in XCR1 expression and osteoblast differentiation. RUNX....

Zhang Y, Li X-H, Peng P, Qiu Z-H, Di C-X, Chen X-F, et al. RUNX2 phase separation mediates long-range regulation between osteoporosis-susceptibility variant and XCR1 to promote osteoblast differentiation. Adv Sci (Weinh). 2025;12:e2413561.
advanced.onlinelibrary.wiley.com/doi/10.1002/...

21.04.2025 14:11 — 👍 3    🔁 0    💬 0    📌 0

RUNX2 Phase Separation Mediates Long‐Range Regulation Between Osteoporosis‐Susceptibility Variant and XCR1 to Promote Osteoblast Differentiation A GWAS intergenic SNP (rs4683184) acts as an enhancer, altering the binding affinity of the transcription factor RUNX2 and resulting in changes in XCR1 expression and osteoblast differentiation. RUNX....

Worried about your pathogenic SNPs? Peer-reviewed 2025 paper shows how phase separation mediates non-coding SNP interactions with their target genes. When the transcription factor RUNX2 phase separates, it can recruit SNP rs4683184, associated with osteoporosis, to increase osteoblast production.

21.04.2025 14:11 — 👍 3    🔁 0    💬 1    📌 0

Thank you Allan!

09.04.2025 19:42 — 👍 0    🔁 0    💬 0    📌 0

Very happy to connect with you on Bluesky. I have been undecided over the switch. It took me quite a few years to build up a modest following at X. I don't mind getting verified for credibility. I do mind having to pay a monthly fee for the privilege.

09.04.2025 19:41 — 👍 2    🔁 0    💬 1    📌 0

ATP is biphasic: low levels promote & high levels inhibit protein aggregation. Novel discovery shows a-Syn amyloids fully degrade ATP at normal cellular concentrations (2 mM), using it to stabilize pathological aggregations. tinyurl.com/e7626sc4 Melatonin complexes with ATP to inhibit aggregation.

09.04.2025 18:43 — 👍 36    🔁 4    💬 2    📌 0