ID-LF

@lisiamouratomich.bsky.social @idclubr.bsky.social @absteward.bsky.social

🌍 🚨 ART Timing & Cryptococcal Meningitis: Starting ART ≤14 days before cryptococcal meningitis diagnosis spikes 2-week mortality to 20.8% vs. 7.1%–13% for longer ART or 12.4% for no ART. 🛑 Pausing ART improves survival.
🔗 Study: doi.org/10.1093/cid/ciae586
#HIV #ART #GlobalHealth #InfectiousDiseases

How to Dose Vancomycin in Overweight and Obese Patients with Varying Renal (Dys)function in the Novel Era of AUC 400–600 mg·h/L-Targeted Dosing - Clinical Pharmacokinetics Background and Objective The latest vancomycin guideline recommends area under the curve (AUC)-targeted dosing and monitoring for efficacy and safety. However, guidelines for AUC-targeted starting dos...

New vancomycin guidelines for obese patients recommend AUC-targeted dosing (400–600 mg·h/L) w/ tailored loading and maintenance doses based on weight, renal function, and ICU status to improve safety and efficacy. doi.org/10.1007/s402.... 💊⚖️ #VancomycinDosing #PrecisionMedicine
@idclubr.bsky.social

Safety of Triple-Dose Rifampin in Tuberculosis Treatment: A Systematic Review and Meta-Analysis There is growing interest in using high-dose rifampin for tuberculosis treatment. Recent studies suggest that triple-dose rifampin (TDR; ≥30 mg/kg/day) may be unsafe. We updated a systematic review to investigate the safety and efficacy of TDR.

Safety of Triple-Dose Rifampin in Tuberculosis Treatment: A Systematic Review and Meta-Analysis

✅ Just Accepted
⭐ Editor's Choice
#IDSky

#Stewardmeme

(Approved 2/2014)

Impact of policy changes expanding access to direct acting antivirals on hepatitis C virus-related hospitalizations in people with HIV: a population-based study The burden of hepatitis C virus (HCV)-related hospitalizations is substantial, particularly among people with HIV and HCV (HIV/HCV). In Ontario, Canada, use of direct-acting antivirals (DAAs) increased following policies removing fibrosis stage restrictions and the approval of pan-genotypic agents in 2017 and 2018, respectively.

Impact of policy changes expanding access to direct acting antivirals on hepatitis C virus-related hospitalizations in people with HIV: a population-based study

✅ Just Accepted
#IDSky