Signal Transduction and Targeted Therapy

This #STTT study identified glycolytic heterogeneity within the #PDAC #TumorMicroenvironment and proposes a novel glycolysis-based framework for patient stratification to guide personalized medicine & #PrecisionOncology.

#OpenAccess: doi.org/10.1038/s413...

An overview of the landscape of #Antiviral #DrugDiscovery and challenges like viral resistance & delivery barriers, while identifying AI-driven design & host-targeting strategies as future development trajectories. @shandonguniversitysdu1901

#OpenAccess: doi.org/10.1038/s413...

A glimpse into what #STTT does!

Publishing high-quality research transcending from basic research to clinical trials to clinical applications. Visit our YouTube page to know more about us: www.youtube.com/watch?v=FghO...

#STTTJournal #CancerResearch #PrecisionMedicine #Bioinformatics

This review explores #CancerNeuroscience, showing how #NeuronalSignaling and neuro-immune factors drive #tumor growth and invasion, and highlights #multiomics targets and hurdles for clinical translation. @northeasternu.bsky.social

#OpenAccess in #STTT: doi.org/10.1038/s413...

This #STTT study reveals that #Gaylussacin inhibits CK2-dependent aberrant activation of CTCF to prevent #ChromatinRemodeling in macrophages, thereby suppressing #ParticulateMatter-induced #ChronicObstructivePulmonaryDisease (#COPD). #Medsky

#OpenAccess: doi.org/10.1038/s413...

#RNAprofiling adds clinical value in cancer therapy: ≥6 altered genes link to shorter survival, while #TP53 mutations correlate with #VEGFA overexpression, suggesting possible #bevacizumab sensitivity. @mdanderson.bsky.social

#OpenAccess in #STTT: doi.org/10.1038/s413...

This study identifies PTHrP1-34 from bronchial epithelial cells as a driver of #IdiopathicPulmonaryFibrosis, providing mechanistic insights that establish it as a critical #TherapeuticTarget for pulmonary intervention.

#STTT #OpenAccess: doi.org/10.1038/s413...

This study defines four consensus #ESCC subtypes and introduces imECMS, a #DeepLearning image-based classifier validated across cohorts, offering a robust framework for #PrecisionMedicine and targeted therapies in #EsophagealCancer.

#OpenAccess #STTT: doi.org/10.1038/s413...

🎙️ New #ESCCardioTalk episode

Another piece of the puzzle: long-term follow-up of conduction system pacing with Pranav Mankad & Kenneth Ellenbogen.

Discover what long-term data means for real-world pacing practice.
👉 https://bit.ly/4cftQfw

#Cardiology #Electrophysiology #ConductionSystemPacing

📹 Joaquim Bellmunt, MD, PhD, of @danafarber.bsky.social discusses the mechanism of action of FX909 in patients with locally-advanced or metastatic urothelial cancer during the 2026 Genitourinary Cancers Symposium. @ascocancer.bsky.social #GU26 #oncology #ASCOGU2026

An overview of #LipidMetabolism in #Homeostasis & disease, highlighting how lipid signaling reprograms #ImmuneCells and exploring innovative therapeutic strategies for #Cancer, #CardiovascularDisease, and metabolic disorders.

#OpenAccess: doi.org/10.1038/s413...

This review highlights #UlcerativeColitis as a #chronicinflammatorydisease with #cancer risk, outlining key cellular pathways, current treatments, and the need for multi-target, personalized therapies to improve patient outcomes.

#OpenAccess in #STTT: doi.org/10.1038/s413...

An overview of #OncolyticVirus (OV) therapy, detailing multimodal mechanisms targeting #Tumorigenesis and #Metastasis while addressing current clinical challenges and future perspectives for enhanced efficacy.

#STTT #OpenAccess: doi.org/10.1038/s413...

This review highlights #EnhancerRNAs as regulators of #geneexpression linked to #cancer, outlining roles in health and disease, diagnostic and prognostic value, and therapeutic potential, while noting current RNA-targeting strategies and challenges.

#STTT: doi.org/10.1038/s413...

Promotional image for ASCO Breakthrough 2026 conference. Text reads: "REGISTRATION OPEN. Singapore, June 25–27, 2026. Early Registration Deadline: May 20 at 11:59 PM (ET)." The background features a world map with illuminated regions and a geometric pattern with the hashtag #ASCOBT26.

Thinking about what’s next after #GU26?

ASCO Breakthrough is happening this June in Singapore! From cutting-edge tech to global clinical insights, it’s an event you won’t want to miss.

There’s still time to register—secure your spot today: https://bit.ly/4cBu2X1

#ASCOBT26

🎙️ On this episode of OncLive On Air, Megan Kruse, MD, of @clevelandclinic.bsky.social, and Sophia O'Brien, MD, of @pennmedicine.bsky.social, discussed how breast cancer imaging aids diagnosis and decision-making. #bcsm #oncology
Listen to the whole episode here ➡️ www.onclive.com/view/breast-...

Dr Mehra on the Safety Profile of Subcutaneous Amivantamab in HNSCC | OncLive Ranee Mehra, MD, discusses the toxicities associated with subcutaneous amivantamab in recurrent or metastatic HNSCC.

WATCH: Ranee Mehra, MD, discusses the toxicities associated with subcutaneous amivantamab in recurrent or metastatic HNSCC. #hncsm #Oncology www.onclive.com/view/dr-mehr...

This #STTT review summarizes the multifaceted role of #Microbiota in #Oncogenesis, #ImmuneModulation, and therapeutic response, discussing the emerging anti-#Cancer strategies targeting microbiota and highlighting future research directions.

#OpenAccess: doi.org/10.1038/s413...

Multiomics #MendelianRandomization links #SERPING1 to #COPD risk; higher levels associate with better #lungfunction and slower FEV₁ decline, while mouse overexpression improves lung health, supporting a complement-pathway biomarker and target.

#STTT: doi.org/10.1038/s413...

#Microbiota-derived deoxycholic acid reprograms #AlveolarMacrophages via TGR5-PKA-STAT3 signaling to suppress pro-#Inflammatory cytokine production, offering a novel #TherapeuticTarget for treating #AcuteLungInjury.

#STTT #OpenAccess: doi.org/10.1038/s413...

A modular albumin-based #BispecificTcellEngagers platform uses SpyCatcher/SpyTag for rapid tumor targeting, extended half-life, dose-dependent cytotoxicity, and stronger suppression than #Cetuximab in #BreastCancerModels.

#OpenAccess in #STTT: doi.org/10.1038/s413...

The WNT5B-NFATc2-MMP14 axis is a critical driver of #HuntingtonsDisease, accelerating ECM degradation, and therapeutic modulation of this pathway with #Genistein reduces #Neuropathology and improves motor coordination. @bumedicine.bsky.social

#OpenAccess: doi.org/10.1038/s413...

#MASLD increases #PDAC risk & #livermetastasis by creating an #immunosuppressive niche driven by the MIF–CD44 axis, which enhances PDAC cell migration, stemness, and adhesion, while MIF inhibition reduces #metastasis, highlighting a targetable pathway.

#STTT: doi.org/10.1038/s413...

Findings from a phase II #ClinicalTrial reveal that perioperative #Penpulimab + #Anlotinib provides promising efficacy and a manageable safety profile for resectable #NSCLC, identifying a potent new combination therapy.
#STTT #OpenAccess: doi.org/10.1038/s413...

Dual SHP2/MEK inhibition in #PDAC triggers mitochondrial remodeling and #LipidPeroxidase dependency, creating a #ferroptosis vulnerability; combining #GPX4 blockade or withaferin A enhances #tumor suppression across PDAC subtypes.

#STTT: doi.org/10.1038/s413...

YTHDF1 regulates chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer.
RNA regulation intersects with treatment resistance.
doi.org/10.1038/s413...
#ColorectalCancer #YTHDF1 #NOTCH1 #CancerStemness #ChemotherapyResponse #Epitranscriptomics

The dysadherin/CA9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression.
Microenvironmental acidity as a driver of malignancy.
doi.org/10.1038/s413...
#ColorectalCancer #TumorMicroenvironment #CA9 #Dysadherin #TumorAcidity #CancerProgression

Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis.
High-resolution insight into tumor evolution.
doi.org/10.1038/s413...
#ColonCancer #SingleCellSequencing #CancerGenomics #Metastasis #TRPS1 #TumorEvolution

5
A comprehensive overview of signaling pathways in colorectal cancer, spanning pathogenesis to targeted therapy.
A roadmap for translational research.
doi.org/10.1038/s413...
#ColorectalCancer #SignalTransduction #CancerPathogenesis #TargetedTherapy #OncologyReview