Giulia Boezio

Happy to share this work from Carlos Camacho de la Maccora that reveals how rates of posterior progenitor addition and anterior vacuolation are balanced across the notochord. With Alberto Ceccarelli and @osvaldo-chara.bsky.social we present a model of long-range communication to provide robustness.

Published 30 years ago, 'The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio' by the Nüsslein-Volhard Lab highlighted the arduous work that took place during 'The Big Screen'. In total, 1163 mutants were described. #ZebrafishFunFacts 🧪

I think that, like with art, papers offer an opportunity for you to tell the story your own way. Could another person research the same question? Yes. However, each person has the opportunity to do it and communicate it in their own way, and we must protect that 🧪

Want to come do a postdoc with us?

We’re interested in how sensorimotor function is carried out by the cells and circuits of the spinal cord. We have an awesome team, lots of cool techniques, and we’re open to new ideas/approaches/connections. Get in touch!

Our latest: A gene selection method for single-cell RNA-seq that identifies developmental & spatial patterns missed by other analysis pipelines

ESFS: A Noise-Resilient Framework for Feature Selection and Marker Gene Discovery in Single-Cell Transcriptomics | bioRxiv www.biorxiv.org/content/10.6...

A competition model of multilineage priming and cell-fate decisions In development, cells navigate highly complex gene-regulatory landscapes to make fate choices. Steinschaden et al. synthesize concepts of multilineage priming, microheterogeneity, and collective multi...

Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...

Ontogeny of the spinal cord dorsal horn The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in beha...

Excited to share @rbrianroome.bsky.social ‘s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org

This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.

www.science.org/doi/10.1126/...

Congrats all, beautiful work! I'm very happy to see it out!

Save the date 23-26 June 2026
The Third Edition of
The PALS Summer School in OMICS is on!
Soon registration+other info
If you are interested to teach (if you are a former participant) please get in touch with me or @remeseiro-lab.bsky.social
🙏 @scilifelab.se @kawresearch.bsky.social

Meeting schedule now online for @bsdb.bsky.social 2026 spring meeting: Molecules to Morphogenesis!

***Abstracts due in by January 16***

Join the outstanding line up! Submit your abstract for a short talk, flash talk, or poster presentation:
👇👇👇
bsdb.org/meetings/

It's always special when you find your own paper in the table of contents of the journal 😍

"The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube" -> Now out in its final form

www.cell.com/developmenta...

Thanks a lot Karina!

Thank you so much, very happy you liked it!

Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks How do transcription factors, with pleotropic functions, generate organized cellular diversity in developing tissues? This study shows that PAX3 and PAX7 orchestrate spinal cord patterning by acting a...

Good to see this study from Ribes & co in print: PAX3/PAX7 transcription factors control neural tube patterning by simultaneously repressing ventral fates via H3K27me3 deposition at silencers & activating dorsal fates as pioneer factors at enhancers
@ribes
journals.plos.org/plosbiology/...

Doctoral clinical fellows The Crick's clinical PhD programme.

Just a few weeks left to apply for our clinical PhD programme.

We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.

Learn more and see what positions are available ⬇️

www.crick.ac.uk/careers-and-...

Evolutionarily conserved transcriptional regulators control monoaminergic neuron development To what extent conserved developmental programs specify homologous cell types is a central question in biology. Here, we address this by focusing on reconstructing monoaminergic neuron development in ...

New preprint out! Evolutionarily conserved transcriptional regulators control monoaminergic neuron development.
We uncover how ancient regulatory programs orchestrate the neurons that produce serotonin and dopamine across 550 million years of evolution.
doi.org/10.1101/2025...

Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*

For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social

www.biorxiv.org/content/10.1...

Thanks a lot, Antoine! Hope to catch up soon.

I am absolutely delighted to share the invited speakers for our upcoming @bsdb.bsky.social "Molecules to Morphogenesis" meeting!

Registration and abstract submission is now open - join us!

bsdb.org/meetings/

March 23-26, 2026 - UK

Join us next year for this amazing conference on human development from many angles

The HDBI has been one of the best things I've got to take part in during my postdoc. Excited to end it with a blast!

Come and join us for a fantastic conference around all things human development and growth!

Lots of talks from abstracts and a stellar lineup of invited speakers? YES.

Hope to see you all there !

@wellcometrust.bsky.social

We've updated our first #preprint from the lab! A collaboration with @jamesbriscoe.bsky.social

🔥 now including in vivo 🐭&👤 embryo data

www.biorxiv.org/content/10.1...

Oh thanks Alejo, that's very kind! And well, thanks for developing the approach, it's amazing to be able to use it in so many systems!

🥹🤍

I'm all ears. Let's chat soon!

Thanks! I'm so glad this GIF got to Bluesky too! What a privilege 😎

Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment

A special thanks to the incredible @crick.ac.uk facilities, HDBR and their donors, the @wellcometrust.bsky.social -funded HDBI consortium, EMBO, URKI and Wellcome.

None of this would have been possible without my amazing coauthors Jasper Depotter, Tom Frith, Arthur Radley, Stephanie Strohbuecker, Ana Cunha and Michael Howell. Special thanks to my mentor @jamesbriscoe.bsky.social for unwavering support and invaluable scientific guidance

This project let me explore some of my favourite questions: how progenitors generate diversity, how lineage sculpts organ complexity, and whether memory & trajectories leave a mark in final cell identity. Grateful for the journey so far, and excited to keep exploring these ideas moving forward!