Juleen R. Zierath

Visited family this past weekend and one of my siblings has this posted in the front yard! I completely agree with each and every point! Happy summer!

Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks. www.nature.com/articles/s42...

Congratulations team! 👍
This will be of interest for muscle physiologists #MyoBlue @myoblue.bsky.social

HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise | PNAS The regulation of metabolism in peripheral tissues is intricately linked to circadian rhythms, with hypoxia-inducible factor-1α (HIF1α) implicated ...

Our latest: HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise. Great teamwork w/ Amy Ehrlich, Kirstin MacGregor & Ste Ashcroft at al! #MyoBlue @myoblue.bsky.social
www.pnas.org/doi/10.1073/...

Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: insights from in vitro analysis Physical activity promotes health, whereas inactivity is associated with metabolic impairment. The transcription factor nuclear receptor subfamily 4 g…

Our latest study connects reduced NR4A3 expression with physical inactivity and indicates that NR4A3 downregulation in human muscle has adverse effects on glucose metabolism and protein synthesis.

Congrats to Jon Smith Brendan Gabriel Nico Pillon & team!

www.sciencedirect.com/science/arti...

Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes - Diabetologia Aims/hypothesis The aim of this study was to investigate effects of time of day on glucose management in individuals with type 2 diabetes undertaking high-intensity interval exercise. Additionally, th...

Our latest!
Great team effort! We found that in men & women with type 2 diabetes, afternoon high-intensity interval exercise appears to be more effective than morning high-intensity interval exercise for maintaining glucose management. @diabetologiajnl.bsky.social
link.springer.com/10.1007/s001...

Attending Keystone Symposia Board of Directors meeting @keystonesymposia.bsky.social planning for future programs & initiatives.

Keystone Symposia serves as a catalyst for the advancement of biomedical & life sciences by connecting scientists within & across disciplines at conferences & workshops

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
Great collaboration with @adeshmukh.bsky.social @JeppeKjaergaard.bsky.social and team @cbmr.science

www.sciencedirect.com/science/arti...

Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice It remains unclear whether the adaptive response to different exercise models is mediated by extracellular vesicle (EV) microRNAs (miRNAs) released fr…

Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise-
New study by Paola Pinto-Hernandez reveals training-induced molecular mediators in the response and adaptation to training.
www.sciencedirect.com/science/arti...

Scientists discover unique molecular fingerprints of insulin resistance Scientists have unearthed surprising details about how our bodies handle insulin – the hormone that plays a crucial role in regulating blood sugar and developing diabetes.

Highlighting our latest research.
Deconvoluting insulin signaling in human skeletal muscle.
www.news-medical.net/news/2025052...

Personalized molecular signatures of insulin resistance and type 2 diabetes.

Great collaboration with @annakrook.bsky.social and @adeshmukh.bsky.social

A comprehensive clinically focused study of insulin signaling in skeletal muscle. 💪

Online today!

www.sciencedirect.com/science?_ob=...

Delighted to attend Genomic Mechanisms of Disease conference! The 31st Science Cluster conference, "Genomic Mechanisms of Disease" brings together experts to discuss research on the genomic influences underlying various diseases. Thx to novonordiskfonden.dk/en/projects/...
@novo-nordisk.bsky.social

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…

Latest from Jonas Treebak and team @cbmr.science

NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...

<em>Journal of Internal Medicine</em> | Wiley Online Library Cardiometabolic diseases—including Type 2 diabetes and obesity—remain leading causes of global mortality. Recent advancements in metabolomics have facilitated the identification of metabolites that a...

Our latest! Great collaborative effort with David Rizo-Roca & John Henderson!
Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes - Journal of Internal Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Congratulations to Mikael Ryden @ki.se @srpdiabetes.bsky.social
Looking forward to this lecture!!

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism
Great collaboration led by Satchin Panda and team! Happy to contribute.
Time to take timing into consideration!!
www.nature.com/articles/s42...

Yes, in fact I do!!

YouTube video by CBMR at the University of Copenhagen Metabolism Day 2025

If you missed Metabolism Day #MD25, @cbmr.science you can catch the talks here! m.youtube.com/watch?v=oUi9...

Happening now! 👍👇

Just wrapping up this Nobel Prize Dislogue Tokyo on the “Future of Life” @nobelprize.bsky.social
Very interesting discussions about opportunities and challenges for all to consider #NobelPrize catch up on the program online
More info here: www.nobelprize.org/events/nobel...

Our latest work by Ste Ashcroft and team -
“Enhanced Metabolic Adaptations Following Late Dark Phase Wheel Running in High-Fat Diet-Fed Mice” is now available online:
doi.org/10.1016/j.mo...

Congratulations! 👍

Honored to be recognized by @easdnews.bsky.social and @novo-nordisk.bsky.social

Postdocs and PhD students hit hard by Trump’s crackdown on science As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.

Postdocs/PhD students hit hard!
“Disruption & uncertainty are the enemy of science,” says Donna Ginther, an economist at the University of Kansas in Lawrence. And when disruption & uncertainty strike, she adds, “the people who lose their jobs are students & postdocs”

www.nature.com/articles/d41...

Indeed!

Congratulations to the scholarship award recipients for the Joint Keystone Symposia: MASH Pathogenesis and Therapeutic Approaches and Obesity and Adipose Tissue #KSMASH25 #KSObesity25 @keystonesymposia.bsky.social 👍

Our latest: @MolMetab
Enhanced Metabolic Adaptations Following Late Dark Phase Wheel Running in High-Fat Diet-Fed Mice
Another great collaboration w/ @Metabolcenter @srp_diabetes
Congrats Ste Ashcroft & team!
Rhythms in metabolism & exercise training

www.sciencedirect.com/science/arti...

👍🥇

Prepping for our latest exercise study! Getting new equipment up and running - or in this case, riding!

Celebrating all Women & Girls in Science today. I have had so many great mentors and colleagues throughout my career! 🙏🏻