⚡️GREG_CORDER⚡️

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Thrilled to share that I’ll be joining the Perelman School of Medicine at the University of Pennsylvania! Our lab will be relocating to the Department of Pharmacology in Jan ’26. We’re hiring at all levels—reach out if you’re interested! @isbupenn.bsky.social @pennmedicine.bsky.social

FAAH inhibitors fail to replicate human KO reports. But check out the many cases of PAIN ASYMBOLIA that also suggest overlap between broad affective-motivational systems and “pain”(READ: unpleasantness) in BLA and posterior insula

become my colleague at penn bioengineering: apply.interfolio.com/173716

Say whaaattttttt!!!!??? FAAAHHHHCKKKK

We could always get some re-interpretation language from NIH but at present the "council in a calendar year" is pretty dang clear. For 2026 Councils, we can submit six apps between May 2025 and March 2026.

so me being super cautious, we have six R01 subs for Oct 5 '25 and Feb 5 '26? Then another 6 for June 5 '26 / Oct 5 '26 / Feb 5 '27?

☝️ do yall know this answer by chance? I am getting so many conflicting interpretations ...
@jasonsynaptic.bsky.social @jeremymberg.bsky.social @drugmonkey.bsky.social

🙏 Please help!

ad nauseam topic but for new NIH n=6 submission policy is it:

a. 6 subs in 2025 calendar year = we can sub 6 R01s for Oct '25 + another 6 for Jan-Dec '26?

b. subs in Oct '25 w/ May '26 Council = we can sub 6 R01s Oct '25 to June '26; count resets Oct '26?

(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium

Have you ever wondered how some of the leaders in the pain field got their start? Check out this essay from @painthejournal.bsky.social about PRF editorial board member, Allan Basbaum, to learn how he became the journal’s 3rd Editor-in-Chief bit.ly/3JIJTXf #PRF #PainAwarenessMonth

Emotion research has a communication conundrum In 2025, the words we use to describe emotions matter, but their definitions are controversial. Here, I unpack the different positions in this space and the rationales behind them—and I invite 13…

My new essay for @thetransmitter.bsky.social. Why is understanding emotion so challenging? The debates around what counts as an "emotion" shed insight.

These disputes are multidimensional, principled and fascinating. Here, I unpack them.

www.thetransmitter.org/the-big-pict...

Phd candidate or postdoc– Genetic determinants of opioid responsiveness The Department of Research and Development at the Division of Emergencies and Critical Care, Oslo University Hospital in collaboration with Leknes Affective Brain lab (www.affectivebrains.com) and the...

What can *genetic insensitivity to opioids* teach us about endogenous opioid function in humans?

Fully funded position in Oslo (PhD student or postdoc)

Interested in pain, mu/kappa opioids, behavioural genetics, RCTs, or related? Apply here:
2411.webcruiter.no/Main2/Recrui...

Please RT for reach

Just heard the same from NIDA PO:

“Your application will get council clearance on Sept 3, however it's unlikely the funding plan will go through in the fall, most likely funding decisions will get pushed to later in 2026, once NIH has a budget.”

I’m going to present on LUPE — our deep-learning system for automated pain behavior analysis — and the Affective-Motivational Pain Scale (AMPS) model for quantifying complex pain states

📄 Preprint: www.biorxiv.org/content/10.1...

💻 Analysis package: github.com/justin05423/...

squidward from spongebob squarepants is sitting in a cardboard box holding a mug ALT: squidward from spongebob squarepants is sitting in a cardboard box holding a mug

im losing too much already 🤑😭

Mouse brain tissue magnified 20 times under a microscope. Pain-processing neurons (red) cluster in the mouse amygdala—its emotion-processing center—and send axons toward the striatum to shape motivational behavior.

A new study pinpoints an emotion-to-motivation gateway that converts painful signals into negative feelings, offering a promising target for non-opioid pain relief.

Learn more in this week’s issue of #ScienceAdvances: scim.ag/46jefZE

Totally get it—here’s the TL;DR 👇

We mapped neurons in the amygdala that makes pain feel unpleasant... Chronic pain rewires it… Quieting those neurons in mice eased that “hurt” …

Pinpointing these neurons and unique genes opens the door to precision, non-opioid painkillers with fewer side effects

ehh, lots of bots to wade thru but im still having good science interactions there (but i also use it to keep up with various sports)

big thanks to all the authors and my co-Senior Collaborator @korblab.bsky.social !!!

... and huge congrats to Jess Wojick who spent 5+ years developing this story (you can keep following her work over at @superkash.bsky.social Lab at UNC)

11. Last, using projection-specific + nociceptive intersectional chemogenetics we linked this BLA-->NAcSh cell-type to acute and chronic pain affective-motivational behaviors

10. BLA-noci axon-photometry over the NAcSh-noci ensemble showed nociceptive transmissions.

In fact, light-touch information used this nociceptive amygdala-striatal pathway during chronic pain states, indicating a role in aversion to allodynia

9. This nociceptive NAcSh ensemble mirrored the functional stability of the BLAnoci ensemble and may show an increased recruitment in chronic pain

... we are now doing calcium iamging of these pain-active NAc cells + opto

8. RNAseq suggested chronic pain alters to downstream axon regulation + signaling. We examined the projection targets of the BLA-noci ensemble to correlate axon density with brain-wide nociceptive hotspots

… we found one very interesting hit—the nucleus accumbens shell (NAcSh)

7. But how does chronic pain impact the BLA transcriptomic landscape?

Next, comparing uninjured vs neuropathic injured groups we discovered multiple up/down-regulated genes that we are now exploring for therapeutic targeting

6. We subset the Rspo2+ neurons into IEG+ clusters responsive to noxious or innocuous stimuli and found functional heterogeneity in this “(-)valence” cell-type.

We found new markers for nociceptive nuclei, eg Htr2a—a target of psychedelics that we're now exploring for analgesia