Journal of Clinical Investigation

The reno-protective effects of SGLT2 inhibitors cannot be fully explained by their glucose-lowering actions.

Quaggin & team now show SGLT2 inhibition increases tissue levels of SAM, resulting in enhanced H3K27 trimethylation & repression of inflammatory genes: www.jci.org/articles/vie...

Genetic and environmental factors converge in congenital craniofacial birth defects

Paul A. Trainor @aussiebiologist.bsky.social & team explore a mouse model of Treacher Collins syndrome, reporting on ROS & genomic instability involved in phenotype variability:
www.jci.org/articles/vie...

Gut complement system: a new frontier in microbiota-host communication and intestinal homeostasis

As part of JCI’s ongoing Review series on complement biology and therapeutics, Xianbin Tian et al. discuss the unique adaptations of intestinal complement: www.jci.org/articles/vie...

Progress towards enhancing #cancer immunotherapies in the context of solid tumors!

William E. Carson III & team show BRD4 inhibition can reduce suppressive immune cells in murine cancer models: www.jci.org/articles/vie...

ICYMI: This issue’s cover art represents the potential for improving pain relief by restoring #circadian rhythmicity.

@ghasemloulab.bsky.social & team link daily pain rhythmicity with neutrophil activation, better biopsychosocial profiles, & reduced opioid use: jci.org/articles/vie...

#Medsky🧪 #immunosky #publichealth This study found circadian rhythms & biopsychosocial characteristics significantly influence opioid use in patients with chronic low back pain (CLBP). Poor circadian rhythmicity is associated with worse pain outcomes & higher opioid use,

From earlier this week: Another installment in JCI’s Review series on complement biology and therapeutics:

Carsten Krieg & Silvia Guglietta highlight the complement system in intestinal inflammation and cancer: www.jci.org/articles/vie...

Super happy about our new publication! JCI - TIE2 activation by antibody-clustered endogenous angiopoietin-2 prevents capillary loss and fibrosis in experimental kidney disease www.jci.org/articles/vie...

Ruling In, Ruling Out: The Clinical Utility of Plasma Biomarkers in Alzheimer’s Diagnosis

This Viewpoint by Julie K Wisch & Beau M Ances frames first FDA-approved test for amyloid pathology in a historical context and highlights implications for practice: www.jci.org/articles/vie...

A die is cast: Autologous neutralizing antibody resistance shapes the HIV reservoir during uninterrupted ART: www.jci.org/articles/vie...

Nancie M. Archin comments on Natalie F. McMyn et al.: www.jci.org/articles/vie...

A major barrier to HIV cure is a population of T cells that harbors replication-competent proviruses

Here, Robert F. Siliciano & team report most viruses in the latent HIV-1 reservoir are resistant to autologous neutralizing antibodies: www.jci.org/articles/vie...

T cell engagers are effective in treating myeloma, but dosing schedules have not been defined.

In this research letter, Madhav V. Dhodapkar & team find in vivo CD4+ T cell fitness within 48 hours following TCE therapy correlates with outcomes: www.jci.org/articles/vie...

The role of perturbation of our circadian clock plays in promoting the fibrosis (scarring) of organs
www.jci.org/articles/vie...

Nicole's collaborative paper accepted. Be on the lookout for the final version at the Journal of Clinical Investigation. www.jci.org/articles/vie...

It's great to see the final version of our SIRT2 paper in JCI along with an astute commentary from trailblazers in beta cell regeneration—thanks for highlighting our work! @likatz.bsky.social @donaldscottmssm.bsky.social @jci.org @sanderlaberlin.bsky.social tinyurl.com/y6rx69x7 tinyurl.com/ydvv9u2s

Another installment in JCI’s Review series on complement biology and therapeutics:

Carsten Krieg & Silvia Guglietta highlight the complement system in intestinal inflammation and cancer: buff.ly/DokQiAr

Maybe you didn’t hear—this molecule is silencing oncogenes

Chad V. Pecot & team developed an inverted RNAi molecule that enhances dual silencing of KRAS and MYC in cancer models: buff.ly/xzjBnEL

Our new paper is out! @ghasemloulab.bsky.social

The cover art was created by @quanamadison.bsky.social
inspired by her own experiences with chronic pain. It all started with a chat at the back of a taxi while at @napainschool.bsky.social and ended up with a beautiful piece of art.

Emerging roles for complement in lung transplantation

As part of JCI’s Review series on complement biology and therapeutics, Hrishikesh S. Kulkarni et al. explore complement activation and strategies for inhibition in the lung transplant process: buff.ly/UXQWFKq

This issue’s cover art represents the potential for improving pain relief by restoring circadian rhythmicity

@ghasemloulab.bsky.social & team link daily pain rhythmicity with neutrophil activation, better biopsychosocial profiles, & reduced opioid use: buff.ly/GR3SOAK

As part of JCI’s ongoing series, Evolving Insights into MASLD and MASH Pathogenesis and Treatment with series editor Scott Friedman @hepascott.bsky.social

Prakash Ramachandran & colleagues consider fibrosis mechanisms as informed by omics approaches: buff.ly/B1PYpFt

SNW1 variants are associated microcephaly, but mechanism for reduced brain volume was unclear.

Ji et al. employ Drosophila and human cerebral organoid models, revealing how SNW1 mutations disrupt RNA splicing, alter neurodevelopmental genes, & reduce the NSC pool:
buff.ly/RGD6ufw

Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...

Our most viewed research article this month...

Integrated screening identifies GPR31 as a key driver and druggable target for metabolic dysfunction–associated steatohepatitis: buff.ly/u8JJGxt

Welcome to the dark zone.

Claudio Tripodo & team leverage spatial profiling and find inhibition of ATR reverses the dark zone signature linked to T-cell exclusion in aggressive B-cell lymphomas: buff.ly/82qjt8s

Just in time for flu season!

Adriana Tomic & team develop an open-source, machine-learning framework for deciphering vaccine response and predicting outcomes: buff.ly/IzKxRGp

Could a gut-derived factor mitigate peripheral inflammation associated with chronic inflammatory disease?

Mario M. Zaiss & team reveal histamine from gut microbiota activates the enteric nervous system and reduces arthritis inflammation in mice via the CNS: buff.ly/fpllUEf

ICYMI: Can we drive anti-tumor immunity in advanced prostate and ovarian cancers?

Arul M. Chinnaiyan & team find pharmacologic degradation of CDK12/13 delays tumor growth and improves ICB response in several cancer models: buff.ly/dtduyFp

From earlier this week: A MRSA strain emerged ~2009 in Brooklyn, NY that is now a major cause of skin infections in the US.

Bo Shopsin & team discover a prophage-encoded methyltransferase that increases virulence by promoting biofilm formation in a mouse infection model:
buff.ly/g0i2DGm

NR2F1 and mTORC1 provide the bridge between melanoma dormancy and therapeutic resistance: buff.ly/3q89Dgt

Narsimha Mamidi, Swadesh K. Das, and Paul B. Fisher comment on Tiago et al. (buff.ly/vR5bwGt)