Joseph Gordon

Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke Reducing Ca2+ leak through mutant RYR1 prevents pathological heat production in skeletal muscle.

www.science.org/doi/10.1126/...

Programmed cell revival from imminent cell death enhances tissue repair and regeneration | The EMBO Journal imageimageThe ability of cells to recover after the initiation of cell death pathways is only little understood. This study challenges the dogma of irreversible cell death by characterizing a programm...

www.embopress.org/doi/full/10....

www.jci.org/articles/vie...

A consensus guide to preclinical indirect calorimetry experiments - Nature Metabolism The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

www.nature.com/articles/s42...

Frontiers Publishing Partnerships | The need to redefine diabetic cardiomyopathy as a unique clinical entity that requires pharmacotherapy

www.frontierspartnerships.org/journals/jou...

Increased mitochondrial fusion via systemic OPA1 overexpression promotes dyslipidemia and atherosclerosis in LDLR deficient mice. Mitochondria are involved in cellular metabolism, energy production, calcium homeostasis, and the synthesis of sterols and bile acids (BAs). Emerging …

www.sciencedirect.com/science/arti...

A quote from the press release: “A parallel study in obese patients without diabetes remains active. Results from this trial will be available in 2026, the company spokesperson said.”

Thanks Kristin!

Thanks DREAM!

Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat | EMBO reports imageimageAcute exogenous acyl-GIP administration promotes brown adipose tissue (BAT) lipid uptake during lipid tolerance tests, augmenting whole-body lipid handling and increases whole-body fatty aci...

www.embopress.org/doi/full/10....

www.nature.com/articles/s44...

Dr. Joseph Gordon recognized with national Open Science research award | University of Prince Edward Island Dr. Joseph Gordon, Biomedical Sciences with AVC and the Memorial Regional Medical Program at UPEI, has received national recognition for his innovative use of research and groundbreaking work investig...

Congratulations, @josephwgordon.bsky.social! 🧪 www.upei.ca/communicatio...

Thanks Krista

The ongoing global epidemic of #MASLD & its close pathogenic & predictive relationship with the non-communicable diseases of #cardiovascular disease, #cancer, #obesity & type 2 #diabetes, allow the inclusion of #MASLD as a new non-communicable disease
www.thelancet.com/journals/lan...
#OpenAccess

www.jci.org/articles/vie...

Can muscle avert GLP1R weight plateau and regain? GLP1R-based obesity therapies can reduce lean muscle and energy expenditure via adaptive thermogenesis (also known as metabolic adaptation), leading to weight plateaus and regain. Defining the role of...

www.cell.com/cell-reports...

I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.

New Molecules and Indications for GLP-1 Medicines This Perspective explores recent progress and future directions in glucagon-like peptide-1 medicines.

The first GLP-1 medicine, twice daily exenatide was approved April 28 2005. Several decades later, the pace of innovation is expanding rapidly, encompassing new medicines and receptors, unique delivery options, and expanding therapeutic indications jamanetwork.com/journals/jam...

Are We Giving Too Much Weight to Lean Mass Loss? The global rise in obesity has underscored the critical importance of body composition, particularly the balance between fat mass and lean mass, in de…

www.sciencedirect.com/science/arti...

The muscle specific MEF2Dα2 isoform promotes muscle ketolysis and running capacity in mice | EMBO reports imageimageThe muscle specific MEF2Dα2 isoform is produced by regulated postnatal alternative splicing. Deletion of this exon in mice causes reduced running capacity and muscle ketolytic gene expressio...

www.embopress.org/doi/full/10....

Congrats to #JF_CoteLab and colleagues for their new #DevelopmentJ paper: Differentially expressed fusogens specify myocyte states to drive myogenesis. #Myoblue tinyurl.com/ykbbex8t

Single-cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1+ macrophage activation Nature Cardiovascular Research - Using single-cell and spatial transcriptomics on muscle samples from non-ischemic patients and patients with peripheral artery disease (PAD), Turiel et al. identify...

Great and unique resource for those who are interested in studying peripheral artery disease mechanisms 👇. Congratulations to Guillermo Turiel and huge thanks to all our collaborators @ethz.ch and Kantonsspital Baden. #PAD #endothelialcells #peripheralarterydisease
rdcu.be/eGpZI

The liver clock modulates circadian rhythms in white adipose tissue Circadian rhythms are integral to maintaining metabolic health by temporally coordinating physiology across tissues. However, the mechanisms underlyin…

Based on studies in mice the authors propose the core clock system as a potential therapeutic target to improve cardiometabolic health. www.sciencedirect.com/science/arti...

Beta-cell adaptation unveiled: The role of myokines in insulin-resistant mice Pancreatic adaptation through increased beta-cell mass occurs when an increased insulin production is required. Liboz, Beaupere, et al. decipher the mechanisms and signals that regulate such adaptatio...

www.cell.com/cell-reports...

Left ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathy | EMBO Molecular Medicine imageimageMolecular profiling of failing human hearts with and without diabetes revealed that diabetes exacerbates mitochondrial dysfunction and extracellular matrix remodelling, especially in ischaem...

www.embopress.org/doi/full/10....

Development of a novel therapy for systolic heart failure | EMBO Molecular Medicine imageimageThe traditional treatment for systolic heart failure compromise heart contractility resulting in reduced cardiac output and exacerbate the symptoms. The newly developed drug-like compound (B...

www.embopress.org/doi/full/10....

Balancing weight and muscle loss in GLP1 receptor agonist therapy - Nature Reviews Endocrinology Rapid weight loss with GLP1 receptor agonists can come at the cost of skeletal muscle, potentially undermining metabolic and functional outcomes. This Comment highlights emerging evidence and advocate...

www.nature.com/articles/s41...

Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells Glucose and paracrine regulation on α-cells, particularly with respect to sex differences, remains unclear. Hence, we imaged islets of GluCre:GCaMP6f^fl/fl mice in pancreatic slices, additionally loaded with a red Ca2+ dye, to precisely interrogate Ca2+ dynamics in α-cells and the adjacent β- and δ-cells. During a glucose ramp (1.8-10.8mM), α-cell Ca2+ oscillations were heterogeneous, antiphasic to β-cells, and inversely correlated with δ-cells. Selective inhibition of insulin receptor (InsR) and somatostatin receptor subtypes-2 and 3 (SSTR2/3) shifted the majority of α-cells to hyperactivity, delayed the decline of α-cell activity and onset of synchronized β-cell Ca2+ oscillations during the ramp. While female α-cells exhibited greater sensitivity to SSTR2/3 inhibition, male α-cells were more responsive to InsR blockade. Under complete SSTR2/3 and InsR antagonism, α-cells exhibited elevated Ca2+ oscillations but remained glucose-dependent. We conclude that intra-islet coordination fine-tunes α-cell glucose responses, with sex-specific paracrine signaling potentially shaping glucagon profiles in metabolic disease. ### Competing Interest Statement The authors have declared no competing interest.

Our new report with #YaChiHuang and #MarjanRupnik deploys high-speed multicellular imaging in pancreatic slices to reveal roles for both cell intrinsic and paracrine mechanisms in glucose inhibition of alpha cells - and the effects are sex-specific. #CRCHUM. www.biorxiv.org/content/10.1...

Germline and somatic variants in DNMT3A and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension AbstractBackground and Aims. Multiple germline gene variants promote familial and idiopathic pulmonary arterial hypertension (PAH); however, none are consi

academic.oup.com/eurheartj/ad...

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation Development of LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution at any defined subcellular location under p...

www.cell.com/cell/fulltex...