Joseph Gordon

UCP2 inhibition eliminates pancreatic β cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines Nature Communications - The relationship between pancreatic β-cell dysfunction and autoinflammation in T2DM is unclear. Here, the authors show the key role of a UCP2/mtDNA/STING axis in the...

UCP2 inhibition eliminates pancreatic beta cell autoinflammation in type 2 #diabetes with MitoG: An #islet #mitochondria targeting nanomedicine @chrisadoucette.bsky.social @dream-diabetes.bsky.social @nature.com
rdcu.be/eAfT2

REVIEW: Role of #mitochondrial function in the pathogenesis of #diabetes @dream-diabetes.bsky.social

frontiersin.org/journals/end...

www.jci.org/articles/vie...

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide va...

physoc.onlinelibrary.wiley.com/doi/10.1113/...

Sarcopenic obesity: pathogenesis, epidemiology and management in older adults Sarcopenic obesity is the confluence of low skeletal muscle mass and function with excess adiposity. Sarcopenic obesity is becoming increasingly prevalent among older adults and may contribute to g...

www.tandfonline.com/doi/full/10....

#myoblue has made so many advances based on MHC hybridomas from @dshb-antibodies.bsky.social

Fifty years of monoclonals: the past, present and future of antibody therapeutics - Nature Reviews Immunology Fifty years ago, Köhler and Milstein introduced the world to hybridoma technology for the generation of monoclonal antibodies. Scientists have subsequently built upon this seminal discovery to develop...

Gotta say I'm a big fan of hybridomas from @dshb-antibodies.bsky.social www.nature.com/articles/s41...

Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish Andrews et al. demonstrate that multiscale feedback between mechanical and chemical cues builds a functional heart to support zebrafish embryonic life. Cell recruitment and organ-scale forces drive tr...

www.cell.com/developmenta...

Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice Loss of lean mass is a potential concern for semaglutide-induced weight loss. This study indicates that semaglutide has unexpected effects on skeletal muscle mass and strength in mice, demonstrating a...

www.cell.com/cell-metabol...

Sympathetic innervation maintains the murine quiescent skeletal muscle stem cell pool via perivascular-derived Angpt1 Sympathetic denervation disrupts muscle stem cell quiescence by triggering premature fusion with myofibers. Rotini et al. identify a neurovascular signaling axis involving β-adrenergic signaling and p...

www.cell.com/developmenta...

and thanks for the citation Karchoptosis !!

Dying for Clarity: Common Pitfalls in Cardiac Cell Death Research - Cardiovascular Drugs and Therapy Cardiovascular Drugs and Therapy -

Great editorial: link.springer.com/article/10.1...

Dysfunctional mitochondria trap proteins in the intermembrane space | The EMBO Journal imageimagePoorly energized mitochondria trap a subpopulation of mitochondrial precursor proteins in the intermembrane space. This article introduces ‘mitochondrial triage of precursor proteins’ (MitoT...

www.embopress.org/doi/full/10....

Quantifying the varying harvest of fermentation products from the human gut microbiota Fermentation products are the most abundant gut microbial metabolites absorbed by the host, with important dose-dependent consequences for health. In this study, we present a systems-level analysis in...

Quantifying the varying harvest of fermentation products from the human gut microbiota: Cell www.cell.com/cell/fulltex...

ACLY inhibition promotes tumour immunity and suppresses liver cancer - Nature Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of ...

www.nature.com/articles/s41...

Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice D-lactate from the gut microbiota influences blood glucose and fatty liver disease. Trapping D-lactate in the gut improves blood glucose and lowers liver inflammation and fibrosis during obesity.

www.cell.com/cell-metabol...

Deletion of PTP1B in cardiomyocytes alters cardiac metabolic signaling to protect against cardiomyopathy induced by a high-fat diet The absence of a phosphatase prevents a cardiomyopathy-inducing metabolic switch in mice on a high-fat diet.

www.science.org/doi/10.1126/...

Evolution of growth factor signaling to the TSC complex to regulate mTORC1 Structural and evolutionary insights are discussed about how the primary brake on mTORC1 activity is lifted.

www.science.org/doi/10.1126/...

Balancing weight and muscle loss in GLP1 receptor agonist therapy - Nature Reviews Endocrinology Rapid weight loss with GLP1 receptor agonists can come at the cost of skeletal muscle, potentially undermining metabolic and functional outcomes. This Comment highlights emerging evidence and advocate...

www.nature.com/articles/s41...

Will spelling count in the Alberta bi-election? How many will be able to spell Poilievre at the ballot box?

onlinelibrary.wiley.com/doi/10.1002/...

Mitochondrial cardiomyopathies: pathogenesis, diagnosis, and treatment Abstract. Mitochondrial cardiomyopathies are a heterogeneous group of disorders caused by dysfunction of mitochondrial energy production due to genetic mut

academic.oup.com/eurheartj/ad...

Happy 12 months since the Second Edition Viral Vectors eBook went live! You can download this helpful guide here: https://twp.ai/4ifKmL

Addgene announces partnership with Promega to launch plasmid collection

We’re thrilled to announce a partnership with ‪@promegacorporation.bsky.social‬ to launch the Promega Plasmid Collection, providing broad access to high-value plasmids for studying target engagement, protein-protein interactions & targeted protein degradation. https://twp.ai/4ioDqY

Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle - Skeletal Muscle Background Small mammals such as mice rely on type IIb myofibers, which express the fast-contracting myosin heavy chain isoform Myh4, to achieve rapid movements. In contrast, larger mammals, including...

New #SkeletalMuscle paper: Large MAF transcription factors reawaken evolutionarily dormant fast-glycolytic type IIb myofibers in human skeletal muscle. #Myoblue tinyurl.com/munak989

SMCHD1 maintains heterochromatin, genome compartments and epigenome landscape in human myoblasts - Nature Communications The authors characterize SMCHD1 as a nuclear lamina-associated protein in human myoblasts where it serves as an anchor for heterochromatin. Loss of SMCHD1 leads to B-to-A compartment transitions and n...

New #NatureComms paper: SMCHD1 maintains heterochromatin, genome compartments and epigenome landscape in human myoblasts. #Myoblue tinyurl.com/bubedsza

Edmonton

Official posting coming soon, but here's a heads-up:

#Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome!

www.bcell.org

Adaptations in mitochondrial quality control and interactions with innate immune signaling within skeletal muscle: A narrative review Skeletal muscle health and function are essential determinants of metabolic health, physical performance, and overall quality of life. The quality of …

www.sciencedirect.com/science/arti...

Mechanically sensitive MAPK signalling mediates resistance exercise-induced muscle growth - Nature Metabolism Understanding the molecular regulators of skeletal muscle mass is essential for the future development of therapies that promote muscle growth and/or inhibit muscle wasting. A new study shows that muscle-building resistance exercise in humans and mice activates a MAPK signalling pathway to increase protein synthesis and stimulate muscle hypertrophy.

www.nature.com/articles/s42...

Identification of a resistance-exercise-specific signalling pathway that drives skeletal muscle growth - Nature Metabolism This study demonstrates that the MKK3b/6 signalling pathway drives the skeletal muscle growth-promoting effects of resistance exercise.

www.nature.com/articles/s42...