Britton Sauerbrei

Britton Sauerbrei

@brittonsauerbrei.bsky.social

Neurophysiologist working on motor control and neural population dynamics. Assistant Prof. at the Case Western Reserve University School of Medicine. https://sauerbreilab.org/

872 Followers 903 Following 192 Posts Joined Nov 2024
1 day ago

1/7 🧠 My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! 🧵

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Congrats!!!

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Hess’ 1949 (trans. 1957) book on the diencephalon: an excellent synthesis of data, survey of the literature, functional atlas, and methods manual. The disappearance of monographs in scientific publishing is unfortunate.

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6 days ago
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This one focuses on modern art, not interdisciplinary connections, but it’s a classic (and, I think, graphically excellent).

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1 week ago
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First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...

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1 week ago
fly circuit diagram

When a fly lands on your arm, how does your nervous system decide where to swat?

By reconstructing tactile axons in a Drosophila connectome, we found a leg somatotopic map and downstream circuits that sample the map to initiate targeted grooming

Led by Leila Elabbady, PhD

doi.org/10.64898/202...

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3 weeks ago

Using our bee-tracking drone, we discovered that honey bees 🐝 have highly precise and individual routes. Now published at @currentbiology.bsky.social : doi.org/10.1016/j.cu...

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3 weeks ago

A remarkable discovery: motor sequences in zebra finch song are generated intrinsically within HVC. Beautiful!

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3 weeks ago
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Feedback control of random networks as a model of flexible motor cortical dynamics across tasks Kalidindi and Crevecoeur develop a computational framework linking feedback-controlled networks to limb dynamics. They demonstrate that optimal control of fixed network reproduces key motor cortical d...

Paper is out by @harikalidindi.bsky.social : feedback control model of neural population activity
www.cell.com/cell-reports...

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1 month ago
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🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...

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3 weeks ago
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Some scientists used to think that birds are just kind of stupid. In the 1960s, the neuroanatomist Harvey Karten’s research into avian neural circuits changed how the field viewed bird intelligence. www.quantamagazine.org/intelligence...

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1 month ago
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Primate dexterous hand movements are controlled by functionally distinct premotoneuronal systems Distinct spinal and cortical pathways coordinate muscle synergies and fine control to support primate dexterous hand movements.

Our paper is out in Science Advances!
What makes primate hands so dexterous?
We show that evolutionarily distinct spinal and cortical pathways work together to balance stability and flexibility, supporting remarkable primate hand control.
www.science.org/doi/10.1126/...

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1 month ago
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New paper alert! 🚨

We found that the brain's compass is remarkably stable at two scales

1️⃣ the system maintains its internal organization for weeks
2️⃣ It "remembers" its orientation for weeks, even after a single visit

This may be key to how the brain aligns its other maps.

Paper: rdcu.be/e3waP

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1 month ago

From Chand: “of potential interest”. Our lab’s first dataset! Tian and friends used Neuropixels to record from 7,500 units across DLPFC and PMd to show how contextual decision making (specifically, XOR computation) occurs and how this differs by location in DLPFC and between areas.

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1 month ago

This is a catastrophic unforced error.

It was quite something to hear @ohsunews.bsky.social President Shereef Elnahal equate the shambolic lies of fringe groups (“others”) with the heartfelt & credible testimony of the scientists & veterinarians in his employ.

“Teammates” don’t support rivals.

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1 month ago

“A sanctuary is not a strategy. It is a capitulation to fear and the political pressure that ignores scientific reality”

Well said @vincentcostaphd.bsky.social

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1 month ago
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Neuro’s ark: Understanding fast foraging with star-nosed moles “MacArthur genius” Kenneth Catania outlined the physiology behind the moles’ stellar foraging skills two decades ago. Next, he wants to better characterize their food-seeking behavior.

Kenneth Catania spoke with @thetransmitter.bsky.social about how the specialized snout of the star-nosed mole allows for high-speed foraging and underscores the importance of studying behavior alongside anatomy.

By Lauren Schneider

#neuroskyence

www.thetransmitter.org/neuros-ark/n...

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1 month ago

We have updated this preprint. I think the deeper dive that @mkashefi.bsky.social has done on the 'shift' condition-independent signal is particularly interesting. www.biorxiv.org/content/10.1...

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1 month ago

Beautiful work - congrats!!!

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1 month ago
A synaptic locus of song learning Learning by imitation is the foundation for verbal and musical expression, but its underlying neural basis remains obscure. A juvenile male zebra finch imitates the multisyllabic song of an adult tutor in a process that depends on a song-specialized cortico-basal ganglia circuit, affording a powerful system to identify the synaptic substrates of imitative motor learning. Plasticity at a particular set of cortico-basal ganglia synapses is hypothesized to drive rapid learning-related changes in song before these changes are subsequently consolidated in downstream circuits. Nevertheless, this hypothesis is untested and the synaptic locus where learning initially occurs is unknown. By combining a computational framework to quantify song learning with synapse-specific optogenetic and chemogenetic manipulations within and directly downstream of the cortico-basal ganglia circuit, we identified the specific cortico-basal ganglia synapses that drive the acquisition and expression of rapid vocal changes during juvenile song learning and characterized the hours-long timescale over which these changes consolidate. Furthermore, transiently augmenting postsynaptic activity in the basal ganglia briefly accelerates learning rates and persistently alters song, demonstrating a direct link between basal ganglia activity and rapid learning. These results localize the specific cortico-basal ganglia synapses that enable a juvenile songbird to learn to sing and reveal the circuit logic and behavioral timescales of this imitative learning paradigm. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, K99 NS144525 (DCS), F32 MH132152 (DCS), F31 HD098772 (SB), R01 NS099288 (RM), RF1 NS118424 (RM and JP)

Where does learning through imitation happen in the brain?

In juvenile zebra finches, we pinpoint a synaptic locus of song learning in a cortico-basal ganglia circuit and leverage this localization to measure the timescale of consolidation and make birds learn faster! #neuroskyence (1/14)

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1 month ago
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Dynamic engagement of the motor cortex in controlling movement Neural circuits do not contribute equally or continuously to behavior. In mice, the motor cortex can be essential or dispensable for movement in different contexts, but how it is dynamically recruited...

Very excited to share a new preprint - my first paper in the @mikeeconomo.bsky.social lab where we asked when and why the motor cortex is recruited for movement control:🧠👇https://www.biorxiv.org/content/10.64898/2026.01.13.699314v1

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The lab comedians wanted some natural light. @eric-kirk.bsky.social

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1 month ago

The Neural Control and Computation Lab is seeking a skilled part-time software engineer in Toronto to lead the development of ATHENA (Automatically Tracking Hands Expertly with No Annotations), our open-source, Python-based toolbox for 3D markerless tracking!

www.yorku.ca/health/resea...

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1 month ago

Congrats @danielavallentin.bsky.social happy to see this out in @currentbiology.bsky.social

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2 months ago

Thanks, Juan!

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2 months ago
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Ontogeny of the spinal cord dorsal horn The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in beha...

Excited to share @rbrianroome.bsky.social ‘s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org

This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.

www.science.org/doi/10.1126/...

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2 months ago
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Neuronal calcium spikes enable vector inversion in the Drosophila brain In the fly central complex, PFNa neurons switch from firing classical sodium spikes when depolarized to firing non-canonical T-type calcium spikes when hyperpolarized. This bidirectional spiking allow...

www.cell.com/cell/fulltex...

We had a lot of fun working on this project (led by Itzel Ishida, not on bluesky). Some interesting highlights from the paper -

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2 months ago
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Here's another, showing raw voltage throughout the dendritic tree, the virtual reality location of the animal, the mouse-eye view, and the voltage at the neuron's soma.

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2 months ago
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What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

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2 months ago
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Ruskin on generative AI.

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