1/5
Introducing SimPlot-CL! 🧬
Recombination plays an important role in viral evolution. Similarity plots are a great way to visualize recombination patterns, but generating them across many genomes can be cumbersome
(Work with my student, Keno Strotjohann!)
📂 github.com/hodcroftlab/simplot-cl
Wow.
Doctors say that vaccines protect children from dangerous diseases. A nepo baby who barbecues dogs and snorts cocaine off toilet seats says that vaccines make children vulnerable to 5G radiation. For busy parents, it can be hard to know who to trust.
Troublemaker is my middle name.
There is a cost to science denial.
Quickly telling someone you’ve liked something they’ve done (e.g. telling a writer you like their writing, or a researcher you like their research, or a teacher you like their teaching) has a phenomenally high effort-to-impact ratio.
Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him.
White. Hot. Rage.
"I know we'll come to (Nato's) rescue, but I just really do question whether or not they'll come to ours"- Trump
Mate, article 5 has been invoked exactly once and guess who it was in aide of...
Not at the moment, seeing his neurologist today for some meds adjusting fun 🤞
Very cool work! I have a cat with epilepsy and it is horrible. Awesome that Cronutt is cured and would be amazing for people suffering with epilepsy too 🤩
OctopuSV and TentacleSV: a one-stop toolkit for multi-sample, cross-platform structural variant comparison and analysis. #StructuralVariants #SVs #SVcomparison #SVidentification #Bioinformatics 🧪🧬 🖥️
academic.oup.com/bioinformati...
Spider: a flexible and unified framework for simulating spatial transcriptomics data. #SpatialTranscriptomics #DataSimulation #Genomics #Bioinformatics 🧬 🖥️
academic.oup.com/bioinformati...
I can say that having been working on this for a while, my cats have insurance in place specifically chosen to cover that cost just in case.
There are several international groups working on prevention and treatment for FCoV-23, so hopefully they should have solid data to share in the near future.
GS-441524 is the recommended treatment and has been used successfully in cases of FCoV-23. Unfortunately it is not available for veterinary use in every country, and is expensive. Molnupiravir was used during the outbreak in Cyprus as there were COVID stocks the government allowed use of.
Also, my black cat says hi to your black cat.
I borrowed that tree as I'm on my phone and it was easier than finding my own! The source of that tree is this chapter, which may be of interest. But simply put, they're quite different. www.sciencedirect.com/topics/immun...
While this is about a coronavirus, it's not about that coronavirus. They're not very closely related, and while we did see cases of cats catching SARS-CoV-2, it isn't going to give your cat deadly FIP. Most cats that catch SARS-CoV-2 have very mild or no respiratory symptoms.
Important insights into FCoV-23 cell entry from the @veeslerlab.bsky.social
Freely available: www.nature.com/articles/s41...
Grok 4 appears to consult Elon Musk's X posts and news about him when addressing controversial subjects like immigration or the Israel-Palestine conflict. This design choice, aiming to align with Musk's views, raises questions about Grok's stated goal of being a "maximally truth-seeking AI."
#MLSky
I've once again failed to tag appropriately for the various sciency bluesky feeds. 🧪🧬🖥️ #ViroSky #VirEvol
A lab is not required to generate chimeric coronaviruses, with a spike of a different virus: they can emerge naturally ▫️1/2
(from newly published paper by Attipa & @amandatron89.bsky.social et al.; preprinted in 2023)
www.nature.com/articles/s41...
Also interesting that the deletion between TGEV and PRCV tracks so closely with the FCoV-23 deletion!
A hybrid coronavirus, formed of cat and dog coronaviruses, caused a severe outbreak of disease among cats in Cyprus, researchers found.
Their work, in Nature, showed how this new virus was able to cause widespread cases of Feline Infectious Peritonitis (FIP) among the island’s cats.
We know it has come up in other European countries, but overall testing rates are low. We are working on some easy diagnostics. So far we've not had reports of any massive die-offs in feral populations so that is a good sign, but it is possible it just hasn't met a good cat dense environment yet.
So there have been more confirmed UK cases, so far all imports, but there may be some local spread that we don't know of. It's difficult to know when essentially the same disease already exists in the country from "normal" FCoVs, we only tend to hear about the imports.
For more on the domain 0 deletion in the spike gene, see another paper, also out today in Nature, looking at how the deletion enhances fusogenicity and entry kinetics.
www.nature.com/articles/s41...
For more on the domain 0 deletion in the spike gene, see another paper, also out today in Nature, looking at how the deletion enhances fusogenicity and entry kinetics.
www.nature.com/articles/s41...
*our
I'm so not redoing the whole thread for one typo though 😅
As a side note, Nature including "Thank you for choosing to publish your work with us." In an acceptance email is wild. I'm not convinced we were the ones doing the choosing, but you're welcome?
Our fur raising findings pose important questions about this novel virus and its potential impact on cat populations, especially in areas with high numbers of feral cats. Better understanding of the virus is important for developing effective treatment and prevention strategies.
