Tianyang Liu

New #cryo-EM #preprint- 'Structural mechanisms of drebrin-mediated F-actin network modulation'. Weilong impressively classified out two small #actin binding domains competing for the same surface on #F-actin, one of which also exists in two conformations! #drebrin

www.biorxiv.org/content/10.6...

03.12.2025 11:20 — 👍 7    🔁 4    💬 0    📌 0

SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion. When stimulated by nucleation-promoting factors such as WAVE, the Arp2/3 complex generates branched actin networks. In contrast, when activated by SPIN90, the Arp2/3 complex generates linear actin fil...

SPIN90 and #YanCao strike again! First NPF to only activate a subset of Arp2/3 iso-complexes to regulate lamellipodial actin & protrusion efficiency. Great collaboration with @romet-jegou-lab.bsky.social #ManosMavrakis polarized fluorescence microscopy rocks 🤘💥🎉
www.biorxiv.org/content/10.6...

03.12.2025 08:29 — 👍 14    🔁 9    💬 0    📌 3

Now for something completely different - Way lab does immunology - check out our @science.org paper - Branched actin networks mediate macrophage-dependent host-microbiota homeostasis. The work was driven by the 2 first authors @luiz90vasc.bsky.social @shainahuang.bsky.social

14.11.2025 09:16 — 👍 20    🔁 3    💬 3    📌 0

Our paper on Arp2/3-mediated bidirectional actin assembly is out @natsmb.nature.com 🚀 After great reviews & community feedback, this version includes new insights beyond the preprint:) Huge thanks to all co-authors!!! @drmichaelway.bsky.social @romet-jegou-lab.bsky.social @carolynmoores1.bsky.social

16.09.2025 20:20 — 👍 4    🔁 2    💬 0    📌 1

Another wonderful collaboration with @alanbrownhms.bsky.social lab 👇
Zhang lab (co-first author @qingweiniu.bsky.social) contribute the doublet structure from Crithidia fasciculata, a model organism that infects mosquitoes.

13.03.2025 22:41 — 👍 20    🔁 1    💬 2    📌 3

Choanoflagellates and other holozoan relatives of animals arranged in the shape of the Eiffel tower. Drawing by Eva Pillai.

Excited to announce the 10th "Choanoflagellates & Friends Workshop" over May 20-22 in our own Institut Pasteur in Paris: 2025choanocon.wordpress.com Registrations open til March 15, abstract til March 5. Pre-conference event for students/postdocs on 19/05. Plenty of slots for selected talks/posters!

17.02.2025 11:41 — 👍 53    🔁 22    💬 2    📌 3

Thank you:)

04.02.2025 17:14 — 👍 0    🔁 0    💬 0    📌 0

Working on actin cytoskeleton and Arp2/3 complex? Check out our latest work～https://www.biorxiv.org/content/10.1101/2025.01.31.635869v1
In this work, we found SPIN90 forms a dimer, facilitating bidirectional actin filament nucleation by activating two Arp2/3 complex #Cryo-EM #Actin #Arp2/3

31.01.2025 21:42 — 👍 22    🔁 11    💬 1    📌 0