John P. Overington

I was 13. The swearing on Plaistow Patricia, the wonderful double entendres and the jolly pathos. My Old Man, I still cry at. Cuts deep.

Apparently it’s 48 years ago since New Boots and Panties was released. A true classic album, survived the test of time for sure!

The now legend of the gluing of the album covers, and the surrealist concept of destroying other records in the store using the cover, I think it is unmatched

For self conscious pseudo-intellectual teenagers from post-industrial Britain in the 1980s this is big news. For the rest of the world - nothing to see here.

I finished my estimate on required compute to make an atomic-resolution virtual cell: 10^38 FLOPs to simulate a human cell for 1 day. We should be able to do this simulation in 2074 using 200 TW of power. 1/3

What’s wrong with wc on the command line?

Nostalgia ain’t what it used to be. Just found a microfiche. Big stack of these. If only I had the reader. I bet they’re museum pieces now.

Just sorting through some old files.
Really fun to step back in time. This must have been 1988 or so. Acetates, permanent markers. None of your AI assistants in putting this together. And it shows 😂😂

As a Brit expat in the States, it’s sad to see that access to the BBC News website is now paywalled. $90 a year!

It’s August in our home, and that means getting ready for Halloween!! The theme this year (apparently) is Labyrinth - here is David Bowie.

A sort of nerdy question around licenses. Imagine I subscribe to a journal in which they don’t allow text mining on the content. Seems fair. But if is store the pdf locally, then my Mac will index it and allow full text searching. Does this count as text mining?

Congratulations!! I heard that a metric to aim for is an H-index that matches your age; hang on, or was it your waist size?

Getting frustrated with the number of resources that disappear, change terms of use, etc. Seems cheeky that people publish in places like NAR Database with an 'open' resource, then flip to closed. Tempted to put together a table of all the NAR DB resources and plot existence/current license....

And while I’m thinking of Nature, their typography has gone downhill. The spacing between words in titles is now atrocious! Defense against OCR LLM tokenization or just poor visual design? 🤣

More seriously though, have there ever been any scholarly reviews of reliability of patent literature for fakery. I realise there are loads of batshit crazy teleportation patents, so restricting to credible applicants/areas should be easy to do.

Bit of an insult for Nature magazine in the Google response to asking if fake patents and fake publications are different.

The times they are a changin’.

Shucks! I’m blushing!!

CASP is the main reason the protein structure prediction technology and research field advanced over the last 30 years. And the main reason AI based methods have been accepted and widely applied in biology. So shortsighted of NIH to postpone or even halt funding. John Moult is a scientific hero.

There is this table of spelling differences from Clarivate webofscience.help.clarivate.com/en-us/Conten... not sure why pantyhose and pajamas made the science list though.

That's it. It's done. I am no longer on the other place. I'm going to miss some of the science on there, and in particular the biotech analyst community seems stuck there, but enough was enough. It had to go.

Thanks, it works to some extent on specific examples, but I want a fairly comprehensive list to help with automated canonicalization/localisation of a large number of text documents. Also in search interface implementation.

Is there anywhere online a free lexicon for alternate spelling of scientific terms between US and UK English. Something that contains the equivalence of sulphotransferase = sulfotransferase, protease = proteinase, etc. But also smart to know that synthase and synthetase are different concepts.

UI oddity of the day - a box to ask if I'm human, which looks like the only option I have is to click to say no, turns out it's a slider hiding as a tick box.

Waiting.

It’s my son’s birthday, so we are at a Metallica concert.

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Would be a shame if during peer review, one of the questions was around ‘what does alphafold say about this region?’

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide - Nature Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin...

This weeks questionable use of AlphaFold is is the prediction of the structure of a novel 12mer peptide BRP. www.nature.com/articles/s41...