Jared Rosenblum

Frontiers | Comorbidities and neurosurgical interventions in a cohort with connective tissue disorders

www.frontiersin.org/journals/neu...

22.01.2025 14:45 — 👍 12    🔁 2    💬 1    📌 1

This study also highlights the importance of high resolution imaging in preclinical and translational studies.

None of this would be possible without the many great scientists on this paper.

Looking forward to many more impactful studies!

20.01.2025 00:44 — 👍 0    🔁 0    💬 0    📌 0

There is a great deal more I could say about this study and its potential impact but I hope this post serves as the seed for a spirited discussion, collaborations, and future studies in the #Biology and #Science communities.

20.01.2025 00:44 — 👍 0    🔁 0    💬 1    📌 0

We found tumors in mice with the genetic variant as young as only post-natal day 8. This finding suggests to us that these tumors are developmental in origin, a concept that may have great clinical impact in screening and management of this tumor syndrome and others.

20.01.2025 00:44 — 👍 0    🔁 0    💬 1    📌 0

Using high resolution imaging, we evaluated individuals with this tumor syndrome and a mouse model we developed for tumors of the head and neck. The mouse imaging was generated using the Mouse Imaging Facility
at NINDS, NIH

20.01.2025 00:44 — 👍 0    🔁 0    💬 1    📌 0

This study highlights why we study rare diseases such as #paraganglioma as a window into how we can better understand and treat more common diseases.

We studied how a genetic variant in hypoxia signaling, which is a hallmark of #cancer, leads to tumor development. 🧵

20.01.2025 00:44 — 👍 0    🔁 0    💬 1    📌 0

Head and Neck Paraganglioma in Pacak-Zhuang Syndrome. Graphical abstract published at Journal of the National Cancer Institute Cancer Spectrum. The image shows the genetic sequence for hypoxia-inducible factor 2 alpha with specific variants found in individuals in the study alongside how these variants impact protein structure and lead to the development of tumors in patients and the corresponding mouse model. Image credit to the Medical Arts department at NIH. The study was performed by the Jared Rosenblum MD, Yasemin Cole, Hussam Alkaissi MD, and others at the NIH and other institutions.

🚨New paper🚨

From my time at NIH as a trainee, now out in JNCI

Head and Neck Paraganglioma in Pacak-Zhuang Syndrome

Huge team effort!

t.co/qEB234ZR61

20.01.2025 00:44 — 👍 1    🔁 0    💬 1    📌 0

Neurosimplicity

You can learn more at neurosimplicity.com

Thanks for asking!

14.12.2024 03:14 — 👍 0    🔁 0    💬 0    📌 0

Jared S Rosenblum MD. Founder | Neurosimplicity, LLC. Completed his post-doctoral training at Harvard and NIH.

Hey #science and #medicine folks! I'm excited to join the Bluesky community. I completed my post-doctoral training at Harvard and NIH. I'm the founder of Neurosimplicity, a med-tech company, and a very proud dog dad. Feel free to reach out to talk science or dogs!

13.12.2024 03:38 — 👍 4    🔁 0    💬 1    📌 0