Genevieve Kendall, PhD

Beautiful work!

Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence for a neural crest origin of the disease. These findings offer new insight into how a single oncogenic fusion can hij...

1/9 Thrilled to share that our paper, “Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm,” is now published in @cp-cellreports.bsky.social! @amatrudalab.bsky.social @crumplab.bsky.social www.cell.com/cell-reports...

Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence Gadek et al. show that embryonal rhabdomyosarcoma formation is defined by the presence of primary cilia and limits SHH pathway competency in early endothelial progenitor cells that disappear during em...

Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence: Cell Reports www.cell.com/cell-reports...
Latest from @hatleylab.bsky.social

A first-in-human study of universal donor CAR NK cells for acute myeloid leukemia could pave a path for a new approach to treating cancer.
#NKCells #CancerResearch #PedSky #AML
https://bit.ly/47RkgO4

Zebrafish people! The @ZDMSociety annual meeting is in Boston this year, with a great lineup. Abstract submission is closing May 27th. Go register now for this always fun conference #zebrafish www.zdmsociety.org/zdm18-home

Congratulations!!! Beautiful work!

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

Thanks Matt! Same to you!

Faculty Position - Center for Childhood Cancer - Columbus, Ohio job with Nationwide Children's Hospital | 12843640 New Faculty Opportunity – Center for Childhood Cancer Research at Nationwide Children’s Hospital

All research areas focused on pediatric cancer will be considered, with an emphasis on developmental biology, epigenetics, functional genomics, model development, transcriptional regulation, cell, oncolytic viral and gene therapy, or computational approaches.

www.nature.com/naturecareer...

Job ad for a tenure-track assistant professor position in the Center for Childhood Cancer Research at Nationwide Children’s Hospital. Broad areas of pediatric cancer research will be considered. Applications will be reviewed on a rolling basis with a final deadline of December 1, 2025.

We are recruiting a tenure-track Assistant Professor in the Center for Childhood #Cancer Research. Come work with me!

More information 👇

Dr. Genevieve Kendall and Dr. Benjamin Stanton’s labs pictured together.

Thank you to our collaborators - what a fantastic team. And we are incredibly grateful to our funders, including the NIH/NCI, Alex’s Lemonade Stand Foundation, the V Foundation for Cancer Research, St Baldrick’s Foundation, American Cancer Society, and CancerFree Kids for supporting our research.🎗️💛

Kucinski et al developed in vivo zebrafish systems to study how an oncogenic transcription factor drives an aggressive pediatric cancer. This supported understanding the oncogene’s earliest activities, where it uses different binding modes to bind silent genes and then activate them. These findings are depicted by zebrafish invading closed DNA (TAAT wrapped around pebbles) or open DNA (GATTACA in plants). Overall, studying early oncogenic activities in a dynamic developmental context reveals critical mechanisms for transformation.

We summarized our findings in this illustration (Credit: Mandy Root-Thompson) depicting zebrafish models to understand the fusion oncogene’s earliest activities, including invading closed DNA (TAAT wrapped around pebbles) or open DNA (GATTACA in plants) to activate neural programs.

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1 oncoprotein function...

We found that PAX3::FOXO1 invades inaccessible chromatin and induces neural programs as one of its earliest activities. We hope to leverage these new models to find actionable targets for children with rhabdomyosarcoma.

Highly quantitative measurement of differential protein-genome binding with PerCell chromatin sequencing Tallan et al. report a versatile approach for highly quantitative protein-genome binding, demonstrating applications for human and zebrafish cells. The proposed PerCell methodology and analysis strate...

These studies were led by graduate students @jackkucinski.bsky.social and Alexi Tallan as part of their dissertation research. We wanted to understand how PAX3::FOXO1 initially interfaces with #chromatin in vivo and developed a new #zebrafish model and analytical pipeline to do so.

Very proud of our partner papers in @cp-cellreports.bsky.social and @cp-cellrepmethods.bsky.social from collaborative work in my lab and Benjamin Stanton's lab focused on fusion-positive #rhabdomyosarcoma. #TeamFishAndChIPs

Congratulations!!! 🎉

🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here:
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing

Blocking protein recycling may help fight anaplastic Wilms tumor.

Our study, led by Dr. Patricia Tiburcio, showed that blocking protein recycling may help fight anaplastic Wilms Tumor—a rare, aggressive childhood kidney cancer. Combining bortezomib with dactinomycin made tumors more sensitive to treatment in the lab. doi.org/10.1016/j.xc...

We are excited to announce the winner of the George Streisinger Award, the 2025 MBL Course Directors! The Streisinger Award will be presented to them at the 19th IZFC in Madison, WI, where they will also present the Award Lecture. Congratulations to all of them!

ZDM18 Abstract Submission — ZDMS

Abstract deadline for #ZDM18 in Boston ends tonight (EST) for those to be considered for oral talks. More details here: www.zdmsociety.org/zdm18-abstra... #ZebrafishMeeting

Zebrafish + behavior?
You come to the right place!
Join us for the ZDMS webinar on Wednesday, June 4th at 10AM ET. Four incredible speakers will be sharing their expertise!
Sign up here 👇
www.zdmsociety.org/2025-zdms-ri...
#zebrafish #neuroscience

MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos Pooled perturbation screens can reveal cellular regulatory networks, yet scaling these techniques for large-scale screens in animals remains challenging. To address this, we developed MIC-Drop-seq, wh...

To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals.

For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.

www.biorxiv.org/content/10.1...

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...

Free Webinar - Cancer research using zebrafish models, #ZDMS 2025 Cancer RIG Meet-up on Wednesday 28 May (10-11.30AM EST) exciting stories by rising stars of zebrafish cancer research field us06web.zoom.us/meeting/regi....

Image of the logo for the Zebrafish Disease Models Conference (ZDM18). Text that reads 'ZDM18 Boston, MA, USA 2025' and two silhouettes of zebrafish that are black and red.

Attention ZDMS Members and greater fish community:

A message from the Local Organizing Committee for #ZDM18!

The Zebrafish Disease Models Society is excited to host ZDM18 in Boston in October! Read this thread for more about the conference and its upcoming deadlines. (1/8)

This year’s 11 NextGen Stars will share their findings on cancer cartography, the dark proteome, cancer-resistant tissues, and more at #AACR25. Learn more about their work and its future implications on the #AACRBlog: www.aacr.org/blog/2025/04...

The Kendall Lab is at #AACR25! Jack Kucinski is presenting in the Developmental Origins and Drivers of Pediatric Cancers poster session on Monday afternoon. Chinmay Sankhe and Delia Calderon are presenting at the Pediatric Cancer Models poster session on Tuesday morning. Hope to see you there!

I really enjoyed my conversation with Rita Fior for our inaugural feature on zebrafish in translational research!

Just finished up the materials for a intro to R workshop I'm running for folks at work. Thought I would post the GitHub to the materials here as well in case it was of use to anyone else: github.com/MVesuviusC/R...

🧬 🖥️ #bioinformatics #genomics #tidyverse #R #rstats #programming #r4ds

This issue of #GENETICS offers updates on 6 model organism databases & knowledgebases: buff.ly/Mn0hIzl
🔎 AgBioData Consortium
🔎 Candida Genome Database
🔎 Saccharomyces Genome Database
🔎 SpudDB
🔎 Unified Phenotype Ontology
🔎 Zebrafish Information Network

Remember to cite your community resources!