Hopfner Lab

🎉 Congratulations to the first authors, Priyanka Aggarwal and Manmohan Sharma!
Their study in the laboratory of Prof. Karl-Peter Hopfner provides important #mechanistic insight into #chromatin #remodeling across diverse #nucleosomalstates. 🧬🔬 #NARbreakthrough #Chromatin #Epigenetics #INO80

We are excited to share our latest cryo-EM study of the human INO80 remodeler, now featured as a Breakthrough article in NAR @narjournal.bsky.social Check it out here and a big shoutout to @priyanka-pdm.bsky.social and Manmohan et al. for their contributions! 🧬

When art meets science! 🤩
Check out Drew's stunning animation of the cellular machinery behind homologous recombination — featuring our favorite DNA repair complex MRN, and other DNA repair heroes! 🧬🔧 @drewberry.bsky.social

🧐Curious about what has happened at the Gene Center over the past 5 years? Take a look at our hot-off-the-press report.🤩
www.genzentrum.uni-muenchen.de/institute/ab...

Colliding ribosomes signal cellular stress LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell.

📣Publication alert!
A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇
www.lmu.de/en/newsroom/...

Check out our paper on nucleosome positioning by our favorite remodeler INO80 in a collaboration with the Bartholomew Lab, finally out in MolCell 🧬

kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

Excited to share our latest contribution in a collab with Helle Ulrich's Lab. Great work by Ronald and Mariia! Thanks to @sfb1361.bsky.social and @imbmainz.bsky.social 🧬🔨

Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP

We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!

Feeling recharged after our lab retreat in Obergurgl 🌞⛰️
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!

We‘re proud to share that our #SFB1361 PhD student, Yilan Fan from the @hopfnerlab.bsky.social, has been awarded a poster prize at the CNIO-CaixaResearch Frontiers Meeting “Machines on DNA and RNA: A Molecular Mechanistic Perspective“ held on 28-30 May 2025 in Madrid, Spain.
Congrats! 🎉

Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex The ATP-dependent INO80 chromatin remodeller slides and repositions nucleosomes to shape and maintain chromatin around gene regulatory elements and replication origins. Recent work uncovered capabilit...

Check out our pre-print on how the human INO80 complex acts on nucleosomes and hexasomes: PostDocs Priyanka & Manmohan et al. solved structures of INO80 bound to several substrates and completed missing questions about similarities of modes of actions across species🧬 www.biorxiv.org/content/10.1...

Now peer reviewed and in its final form @natcomms.nature.com

www.nature.com/articles/s41...

Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generi...

Happy to share our latest pre-print!
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨
www.biorxiv.org/content/10.1...

Congratulations to our SLFN team - @michaelkugler.bsky.social, Felix Metzner and Katja Lammens for uncovering yet another intricate mechanism! Special thanks to Gregor Witte for his contribution! #innateimmunity #cryoEM #structuralbiology

Hello, Bluesky!
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.

Check out our new paper here www.nature.com/articles/s41... + movie