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Hopfner Lab

@hopfnerlab.bsky.social

Structural biology on DNA repair, chromatin remodelling and innate immunity. Located at the Gene Center of the LMU in Munich. https://www.genzentrum.uni-muenchen.de/research-groups/hopfner/index.html

289 Followers  |  112 Following  |  3 Posts  |  Joined: 21.11.2024  |  1.8184

Latest posts by hopfnerlab.bsky.social on Bluesky

Now peer reviewed and in its final form @natcomms.nature.com

www.nature.com/articles/s41...

21.07.2025 12:59 — 👍 34    🔁 10    💬 2    📌 1
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Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generi...

Happy to share our latest pre-print!
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨
www.biorxiv.org/content/10.1...

17.03.2025 09:43 — 👍 52    🔁 18    💬 2    📌 1

Congratulations to our SLFN team - @michaelkugler.bsky.social, Felix Metzner and Katja Lammens for uncovering yet another intricate mechanism! Special thanks to Gregor Witte for his contribution! #innateimmunity #cryoEM #structuralbiology

03.12.2024 13:00 — 👍 4    🔁 1    💬 0    📌 0
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Hello, Bluesky!
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.

Check out our new paper here www.nature.com/articles/s41... + movie

03.12.2024 13:00 — 👍 31    🔁 12    💬 1    📌 1

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