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Electron crystallography is the branch of science that uses electron scattering and imaging to study the structure of matter

Interested in Electron Crystallography?
#IUCr2026 has you covered with 7 focused sessions including 4D-STEM advances; small molecule determination; nanocrystallography of inorganic compounds; from single crystal to serial diffraction; and more!
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PDB101: Learn: Paper Models PDB-101: Training, Outreach, and Education portal of RCSB PDB

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Visit PDB-101 for downloadable paper templates to create DNA, viruses, red and green fluorescent proteins, and more

IUCr 2026 logo next to someone holding a passport next to a Canadian flag

International attendees are encouraged to visit the #IUCr2026 website for information about entering Canada for the conference, including visa / travel authorization requirements, documentation, timeline tips, and common pitfalls
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PDB101: Browse Resources by Category PDB-101: Training, Outreach, and Education portal of RCSB PDB

Throughout 2024 and 2025, PDB-101 has focused on the them of #peakperformance, highlighting the structural biology of athletics and well-being

Which PDB-101 category should our focus be for 2026-2027?

PDB101: Molecule of the Month: FOXP3 A master transcriptional regulator of immune tolerance

December's Molecule of the Month features a master transcriptional regulator of immune tolerance with a Nobel Prize connection

IUCr 2026 Grants

Apply for #IUCr2026 travel grants
Funds are available to support students, early-career researchers, and participants from under-resourced institutions and/or developing countries.
Details at event.fourwaves.com/...

IUCr 2026 Pre-meeting workshop: OneDep

Register for hands-on workshops held just before the start of #IUCr2026
In the PDB Deposition Workshop, attendees will learn how to leverage various OneDep features and tools; how to complete depositions with minimal manual input; and more
Details: event.fourwaves.com/...

PDB101: Learn: Videos: Target Zero: Preventing HIV Transmission Documentary Target Zero shows the challenge and emotional complexity of the fight to control HIV infection.

Watch the documentary Target Zero to learn about the challenge and emotional complexity of the fight to control HIV infection

PDB101: Browse: HIV and AIDS PDB-101: Training, Outreach, and Education portal of RCSB PDB

Using PDB structures, researchers designed treatments for HIV infection, which are now part of effective drug regimens that halt the growth of the virus. Learn more at PDB-101
pdb101.rcsb.org/brow...
#WorldAIDSDay

AI-Designed Antibodies Achieve Atomic Precision to Enhance Drug Discovery David Baker’s Nobel Prize winning lab has generated antibodies from scratch that target user-specified binding sites for AI therapeutic design.

AI-Designed Antibodies Achieve Atomic Precision to Enhance Drug Discovery

Computational process could condense decades of disease biology research into days At 10 one-millionths of a meter wide, a single human cell is tiny. But something even smaller exerts an enormous influence on everything a cell does: proton concentration, or pH. On the microscopic level, ...

Computational process could condense decades of disease biology research into days

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected Nature - In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Great discoveries often arise from work that was looking for something completely different

PDB101: Molecule of the Month: Pepsin Pepsin digests proteins in strong stomach acid

During the holidays, we often place greater demands on our digestive system. It contains tough, stable enzymes designed to find rich treats and break them into pieces. Pepsin is the first in a series of enzymes that digest proteins. #HappyThanksgiving

Poster Prize Awarded at The Protein Society Congratulations to Emily Schaffter (Clark University) for Differential Interactions between Calmodulin and the IQ Motifs of the HECT E3 Ubiquitin Ligases UBE3B and UBE3C

Congratulations to Emily Schaffter (Clark University) for her wwPDB Foundation Poster Prize awarded at The Protein Society for "Differential Interactions between Calmodulin and the IQ Motifs of the HECT E3 Ubiquitin Ligases UBE3B and UBE3C"

PDB101: Learn: Videos: Immunology and Cancer This three-part series explores the human immune response to cancer focusing on cellular and molecular details of the process.

Video: Immunology and Cancer
Visit PDB-101 to watch a three-part series exploring the cellular and molecular details of the human immune response to cancer. Now available in English and Spanish.

PDB101: Learn: Guide to Understanding PDB Data: Introduction PDB-101: Training, Outreach, and Education portal of RCSB PDB

Visit PDB-101's Guide to Understanding PDB Data to get started with finding and exploring the hundreds of thousands of 3D structures in the PDB archive.

mRNA Vaccines and Immuno-oncology: Good News mRNA Vaccines and Immuno-oncology: Good News

Study suggests that some mRNA vaccines can potentiate the actions of some immune-checkpoint therapies used in oncology.

X-Rays Shed Light on Possible New Treatments for TB Using ALS beamlines, a new study revealed how CMX410 inhibits Pks13, a cell wall enzyme in Mycobacterium tuberculosis, the bacterium responsible for tuberculosis. CMX410 is effective against drug-sensitive and drug-resistant strains of the bacterium and has been proven safe in multiple animal models of infection. Read more »

Data collected at the Advanced Light Source (ALS) and other Department of Energy light sources revealed the crystal structure of CMX410, a new compound that targets a key enzyme (Pks13) in the cell membrane of the bacterium responsible for tuberculosis

PDB101: Molecule of the Month: RSV Fusion Glycoprotein Structures of the fusion glycoprotein from respiratory syncytial virus (RSV) were used to engineer effective vaccines to fight viral infection.

Structures of the fusion glycoprotein from respiratory syncytial virus (RSV) were used to engineer effective vaccines to fight viral infection
More at PDB-101:

PDB101: Register for the Nov 24 Virtual Office Hour on Exploring CSMs at RCSB.org PDB-101: Training, Outreach, and Education portal of RCSB PDB

Register for the Nov 24 Virtual Office Hour on Exploring CSMs at RCSB PDB
Learn how to use RCSB PDB features to navigate 3D Computed Structure Models from AlphaFold DB and ModelArchive

PDB101: Tutorial: Introduction to Molecular Animation PDB-101: Training, Outreach, and Education portal of RCSB PDB

Watch the Tutorial: Introduction to Molecular Animation at PDB-101
Learn how to use ChimeraX to create simple animations that can enrich your presentations, websites, and social media

PDB101: Browse: Antimicrobial Resistance PDB-101: Training, Outreach, and Education portal of RCSB PDB

Nov 18-24 is World Antimicrobial Awareness Week
PDB structures help us understand resistance to antibiotics and develop new ways to fight infection #AMR #WAAW #WorldAntimicrobialAwarenessWeek

PDB101: Learn: Paper Models: Human Papillomavirus (HPV) The capsid protein of papillomavirus is used in vaccines that prevent cervical cancer.

November 17 is designated by the World Health Organization (WHO) as the Cervical Cancer Elimination Day of Action.
Visit PDB-101 to learn how the capsid protein of papillomavirus is used in vaccines that prevent cervical cancer.

Bowhead Whales Live Long Lives. Do They Hold the Key to Human Longevity? A cold-activated gene that helps the mammals repair their DNA may also help humans live longer

A cold-activated gene that helps the mammals repair their DNA may also help humans live longer

This finding reveals a new target for modulating Sir2, an enzyme essential for many biological processes, including aging, metabolic regulation, and cancer suppression.
www.isct.ac.jp/en/ne...

PDB101: Browse: Diabetes PDB-101: Training, Outreach, and Education portal of RCSB PDB

PDB structures reveal how glucose levels are regulated in the body and provide hope for combating diabetes. Explore resources and articles about insulin and diabetes at PDB-101 #WorldDiabetesDay

Congratulations to Miguel Arbeláez (University of São Paulo and National University of Colombia) and Francisco Patrick Ferreira da Silva (Federal University of Ceará, Brazil), who were recognized with wwPDB Foundation poster prizes at LACA
www.rcsb.org/news/69...

PDB101: Molecule of the Month: GLP-1 Receptor Agonists Popular and effective drugs for the treatment of obesity and diabetes

More at November's Molecule of the Month on GLP-1 Receptor Agonists

The GLP-1 receptor, which is a member of a large class of G protein-coupled receptors, undergoes a series of conformational changes when it is activated. In the absence of an agonist, the extracellular domain of the receptor is closed and interacts with the transmembrane domain (PDB 6LN2). On the intracellular side, the structure is tightly packed, stabilized by interactions between amino acids in different alpha helices. Upon binding GLP-1 (shown in pink on the right, PDB 6X18), the extracellular domain moves up to accommodate the ligand, which also causes an opening on the intracellular side of the receptor. This allows the binding and activation of a G protein (not shown), which in turn pushes one of the receptor’s transmembrane helices outward. The result is a disruption of stabilizing contacts within the receptor and the initiation of downstream signaling that influences appetite and metabolism.

GLP-1 receptor agonists got their start in an unlikely place: the mouth of a lizard. A peptide discovered in Gila monster saliva, called exendin-4, was found to mimic the action of GLP-1 and was developed into the drug exenatide (Byetta) for type 2 diabetes treatment.