RCSB Protein Data Bank

PDB101: Molecule of the Month: Ebola Virus Proteins Structures of ebola virus proteins are giving new hope for fighting this deadly virus

The genome of ebola virus contains instructions for building seven proteins, which assemble with the genomic RNA to form one of the deadliest viruses.

PDB101: Browse: Immune System PDB-101: Training, Outreach, and Education portal of RCSB PDB

The bloodstream is filled with molecules and cells that search for invaders and destroy them if they are found. PDB structures have revealed how the immune system recognizes viruses and bacteria while leaving our normal molecules alone.
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After bizarre journey, prized history of molecular biology archive finds new home Science History Institute makes public multimillion-dollar collection, including Rosalind Franklin’s famous DNA image, assembled by fake scientist

Science History Institute makes public multimillion-dollar collection, including Rosalind Franklin’s famous DNA image, assembled by fake scientist

Host Proteins Identified in SARS-CoV-2 Replication Pathways Reveal Drug Targets New research reveals promising drug targets to block coronaviruses at multiple stages of infection—even across different strains.

These findings could open the door to new drugs that target host proteins rather than the virus. This strategy may lead to new treatments effective against SARS-CoV-2 and other coronaviruses, even as the pathogens continue to evolve.

PDB101: Browse: Nobel Prizes and PDB structures PDB-101: Training, Outreach, and Education portal of RCSB PDB

Visit PDB-101 to explore connections between Nobel Prizes and more than 50 years of open access to the PDB archive.
Who will win next week?

PDB101: Register Now for Webinar: Exploring the Workhorses of Biotechnology PDB-101: Training, Outreach, and Education portal of RCSB PDB

Register Now for Webinar: Exploring the Workhorses of Biotechnology
On November 6, learn how to use RCSB PDB to analyze plastic-degrading enzymes

PDB101: Molecule of the Month: Incretins GLP-1 and GIP are hormones that are released soon after you eat a meal

Within minutes of starting to eat, cells in your gut rev into action and start secreting two peptide hormones--glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). These hormones are known as incretins.
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PDB101: Irina Bezsonova Gallery PDB-101: Training, Outreach, and Education portal of RCSB PDB

Explore PDB-themed #Inktober #SciArt images from structural biologist Irina Bezsonova from (2023 and 2022)

The Pairwise Structure Alignment Tool (https://www.rcsb.org/alignment) can align one or more protein chains to a reference structure in a pairwise manner. This tool allows for simultaneous analysis and visualization of three-dimensional (3D) structure alignments and structure-based one-dimensional ( Introduction to RCSB PDB’s Pairwise Alignment Tool

Watch the Pairwise Alignment Tool Office Hour and learn how to align one or more protein chains to a reference structure in a pairwise manner

Host Proteins Identified in SARS-CoV-2 Replication Pathways Reveal Drug Targets New research reveals promising drug targets to block coronaviruses at multiple stages of infection—even across different strains.

An siRNA screen performed by scientists at Scripps Research has pinpointed dozens of human proteins that SARS-CoV-2 uses to complete its replication cycle. These findings could open the door to new drugs that target host proteins rather than the virus.

News - Scientists discover why the flu is more deadly for older people - University of Nottingham Scientists have discovered why older people are more likely to suffer severely from the flu, and can now use their findings to address this risk.

In a new study, experts discovered that older people produce a glycosylated protein called apoplipoprotein D (ApoD), which is involved in lipid metabolism and inflammation, at much higher levels than in younger people

Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report Introducing the latest wwPDB Percentile slider based on the Q-score model-map validation metric

wwPDB has introducing the first 3DEM Model-Map percentile slider (based on Q-score) to validation reports

Ataxia: A symptom and a disease It's International Ataxia Awareness Day.

September 25th is International #Ataxia Awareness Day
PDB structures help us better understand the disease and treament options

MolViewSpec: a Mol* extension for describing and sharing molecular visualizations Abstract. Data visualization is a pivotal component of a structural biologist’s arsenal. The Mol* Viewer makes molecular visualizations available to broade

MolViewSpec: describe, share, and reproduce Mol* molecular scenes with a simple extension

Register for the Sept 25 Virtual Office Hour on PDB Policies Learn about PDB policies about deposition and biocuration.

Register for the Sept 25 Virtual Office Hour on PDB Policies
Learn about PDB policies about deposition and biocuration.

PDB101: Learn: Flyers, Posters, & Calendars: Posters: Folding of Protein Domains This poster highlights common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme.

Download this PDB-101 poster highlighting common arrangements of secondary structure elements in protein domains as defined using the CATH classification scheme

PDB101: Molecule of the Month: Amyloid-beta Precursor Protein Cell-clogging amyloids form when proteins improperly aggregate

Amyloid-beta precursor protein (APP) is a complicated protein with many functions. A corrupted form can destroy nerve cells, leading to the loss of thought and memory in Alzheimer's disease.
#WorldAlzheimersDay

PDB101: Molecule of the Month: Opioid Receptors Morphine and other opioid drugs bind to receptors in the nervous system, controlling pain

September 21 is #NationalOpioidAwarenessDay
Morphine and other opioid drugs bind to receptors in the nervous system, controlling pain

PDB101: Molecule of the Month: Amyloids Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

September 21 is #WorldAlzheimersDay
Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

PDB101: Register Now for Webinar: Exploring Integrative Structures with RCSB.org PDB-101: Training, Outreach, and Education portal of RCSB PDB

Register Now for Webinar: Exploring Integrative Structures with RCSB PDB
On November 12, learn how to explore PDB structures determined using integrative and hybrid methods with RCSB PDB tools

Celebrating the Work and Achievements of Pioneering Chemists During Hispanic Heritage Month | ACS Publications Chemistry Blog Join us in honoring the innovations of Hispanic and Latinx chemists from Spain, Mexico, the Caribbean, and Central and South America, with a curated selection of research and resources from the American Chemical Society.

Join the American Chemical Society in celebrating Hispanic Heritage Month with a curated selection of research and resources

PDB101: Molecule of the Month: Pepsin Pepsin digests proteins in strong stomach acid

PDB-101 materials explore the structural biology of nutrition
Learn how our digestive system contains a host of tough, stable enzymes designed to seek out food and break them into small pieces. #peakperformance

this is the kind of thing that got me into protein folding research (though it was less literal paper folding than this, it was more "this reminds me of origami and l like origami a lot maybe I should do this") so Love this

PDB101: Learn: Paper Models: Creating Paper Models of Protein Domains Download printable alpha helices and beta strand templates for hands-on exploration of many protein folding domains.

Molecular Origami: Build 3D Paper Models of Protein Domains

Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.

Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons

AI Uncovers New Antibiotics in Ancient Microbes - Penn Engineering Blog They’ve survived for billions of years in boiling acid, deep-sea vents and salt flats. Now, some of Earth’s oldest life forms — microbes called Archaea … Read More ›

They’ve survived for billions of years in boiling acid, deep-sea vents and salt flats. Now, some of Earth’s oldest life forms — microbes called Archaea — are offering a new weapon in the fight against one of today’s most urgent health threats.

Examples of ABA created in Jsmol

Researchers are looking to develop ABA analogs that can be sprayed on crop plants during droughts to reduce the amount of water needed during irrigation.
More at September's Molecule of the Month look at the Abscisic Acid Receptor:
pdb101.rcsb.org/motm...

PDB101: Learn: Other Resources: Bound! Protein-drug matching game Bound! is a card game for students 12 and up, where players compete to match the most drugs to their protein targets.

Players match protein targets with drugs in this game developed by RCSB PDB and @ccdc.cam.ac.uk

PDB101: Learn: Other Resources: Molecular Backgrounds For Virtual Meetings Download images created by David Goodsell to add a molecular backdrop to your next virtual meeting. Click on the image to expand.

Download images created by David Goodsell to add a backdrop to your next meeting.

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