Nina Tsvetanova

Way to go, Lauren and lab 💪🎉.

Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...

Now online @nature.com!

Want to change the consequences of receptor activation?

Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥

So many new possibilities! 🧪🧠🟦

www.nature.com/articles/s41...

🧵👇

The lab had an excellent time at the annual Duke Pharmacology & Cancer Bio retreat! Katherine gave a great talk, and she and Matt each won a department award to recognize success in obtaining a fellowship and an impactful publication, respectively. 🎉

Functionally, these molecular changes translate into remodeled neuronal architecture:

➡️ Enhanced dendritic arborization
➡️ Synapse formation

This highlights a mechanism by which receptor trafficking can contribute to neuronal plasticity. Intracellular GPCRs for the win! 4/4

We show that internalized receptors are not silent passengers: they remain active on endosomes and drive extensive neuronal gene expression rewiring through CREB-dependent transcription and mTOR-dependent translation. 3/4

GPCRs are classically known for their signaling at the plasma membrane. But what happens after they internalize into endosomes? We asked how endocytosis of the β2-adrenergic receptor influences neuronal function. 2/4

Our preprint “GPCR endocytosis rewires neuronal gene expression and cellular architecture” is now live on bioRxiv.
🔗 doi.org/10.1101/2025...

We uncover how GPCR trafficking shapes protein content and neuronal structure. Congratulations to our team members, Katherine Hall and Matt Klauer!

A short🧵

📣 We are looking for a full-time research technician. This is a great opportunity for recent grads seeking additional hands-on experience before grad or med school. Join our team in exploring GPCR signaling and pharmacology at @dukemedschool.bsky.social Description: careers.duke.edu/job/Durham-R...

Great science and stunning views of the Niagara Falls at the GRK and arrestin @faseborg.bsky.social meeting. Thanks to @sudarrajagopal.bsky.social @calebirolab.bsky.social @joann-trejo.bsky.social and Irene Coin for organizing an excellent conference and for the invitation. #GKASRC

Congrats to our grad student Peter on successfully passing his prelim 🎉

Celebrating all wins- big and small. Marking our new grant with a great evening of bowling and bonding with our collaborators, the Walsh lab at UNC!

Chemical biology approaches to resolve the subcellular GPCR signaling landscape - Nature Chemical Biology This Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of sign...

A new Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of signaling protein networks and mechanistic screening

www.nature.com/articles/s41...

Chemical biology approaches to resolve the subcellular GPCR signaling landscape - Nature Chemical Biology This Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of sign...

Check out our later take on GPCR signaling in space and time and the toolbox of chemogenetic and chemical biology approaches to explore this cool phenomenon ⬇️. I had a blast working with my colleagues @MiriamStoeber, @cyclic_Andreas and Braden Lobingier.

doi.org/10.1038/s415...

Congratulations to Malarie on passing her prelim exam with flying colors 🎉🍾

Celebrating some exciting wins in the Tlab lately (grants awarded, papers accepted, new jobs, and experiments finally behaving) with 🍹🌮

🎉 Thrilled to announce we have received the NoA for our new NIMH R01! Excited for the discoveries ahead and grateful to the NIH for the support.

Congrats!

Huge congratulations to Dr. Matt Klauer on a terrific PhD defense 🎊! Matt excelled consistently throughout his candidacy and has started a number of exciting new directions in the lab 🔬. We wish him all the best as he embarks on the next chapters of his scientific journey 👨🏻‍🎓🍾🎉

Excellent news! Congratulations, Gavin.

We used ribosome profiling to uncover a vast translational regulatory program controlled by a prototypical GPCR and second messenger. This is dependent on receptor compartmentalization and driven by spatially confined GPCR-dependent activation of #mTOR.

Excited to share the publication of our latest #NIH funded work led by Matt Klauer where we determine how #GPCRs shape the translational landscape of cells: www.pnas.org/doi/10.1073/...

@bookmarkth.is; great question, I bet many of us I would love to know

Thank you, Karen!

Some much-needed good news 🎉: I am honored to receive the ASPET Molecular Pharmacology Division Early Career Award. Big thanks to Mikel Garcia-Marcos for the nomination. I am very grateful for the support and recognition by my colleagues at #ASPET and beyond.
ow.ly/nYiB50UNQLF

Excellent work @amanglik.bsky.social @willowcoyote.bsky.social and @justingenglish.bsky.social!!

Congrats, Dan!!

I am thrilled to congratulate Katherine Hall in the lab on being awarded an @americanheart.bsky.social predoctoral fellowship 🎉! Way to go!!

Congratulations, JoAnn!

👋 We study GPCR signaling and trafficking. Thank your for putting this together

Can’t wait to read this! Congrats, Lauren and team! 🎉