Sameer Jauhar

Brain chemistry reveals psychiatry’s false divisions – new study Dopamine clues reveal a common thread in psychosis.

Dopamine clues reveal a common thread in psychosis.

26.08.2025 14:47 — 👍 21    🔁 7    💬 1    📌 0

So what?
Fair points- limbic selectivity for mood psychoses mapping onto therapeutic agents, and transdiagnostic approaches for positive symptoms?
I will take that, though happy for critique!

14.08.2025 23:38 — 👍 0    🔁 0    💬 0    📌 0

DA lowers in ppl w psychosis and MDE than ppl w mania (esp Mesolimbic system)
DA correlated w positive sx, across diagnoses (esp associative striatum)
Take home?
Symptoms track biology as opposed to diagnoses, though differences still exist across disorders.

14.08.2025 23:38 — 👍 0    🔁 0    💬 1    📌 0

Answers-look at the Figures, see what you think

14.08.2025 23:38 — 👍 0    🔁 0    💬 1    📌 0

We used PET to examine dopamine synthesis in ppl w psychosis and mood disorders.
2 questions:
i) Is DA reduced in ppl w psychosis+ major depressive episode?

ii) Is there a relationship between DA and positive psychotic sx (delusions and hallucinations) across affective psychoses?

14.08.2025 23:38 — 👍 0    🔁 0    💬 1    📌 0

Dopamine and Mood in Psychotic Disorders This cross-sectional study uses fluorine F 18–labeled fluorodopa (18F-DOPA) positron emission tomography (PET) to test for differences in dopamine synthesis capacity between affective syndromes across...

Does Mother Nature read the DSM? Probably not. Our paper just out in @jamapsychiatry.com jamanetwork.com/journals/jam...

14.08.2025 23:38 — 👍 2    🔁 0    💬 1    📌 0

Are cognitive behavioural therapy, cognitive therapy, and behavioural activation for depression effective in primary care? A systematic review and meta-analysis Cognitive behavioural therapy (CBT) is a recommended first-line treatment for depression. Evidence mainly derives from studies in secondary care, thou…

www.sciencedirect.com/science/arti... CBT for MDD in 1rycare no better than active comparator and low quality evidence. Our MA, oh dear

25.04.2025 19:37 — 👍 2    🔁 0    💬 0    📌 0

Looks like I may have some teaching to do in my new job at Imperial. Thanks, Dr Moncrieff!

22.03.2025 22:58 — 👍 3    🔁 0    💬 0    📌 0

What he would wish if he had a psychotic illness, and.....favourite pizza topping!

19.03.2025 22:33 — 👍 0    🔁 0    💬 0    📌 0

5:00 mins- “ I naively thought all novels were fiction”
“science is failure”
Just treat patients for a week and make a note every time you feel anxious, there is a research question there....."

19.03.2025 22:33 — 👍 2    🔁 0    💬 1    📌 0

Rolling Thunder - An evening with Professor John Kane (subtitled) - King’s College London

Great fun interviewing John Kane, who came out with some beautiful insights media.kcl.ac.uk/media/Rollin...

19.03.2025 22:33 — 👍 2    🔁 1    💬 1    📌 0