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BK. Titanji

@boghuma.bsky.social

Physician Scientist MDPhD Infectious Diseases Academic Medicine Global Health Science Communicator Posts are my opinions, not my employer's and not medical advice I bet on myself and double down https://substack.com/@bktitanji

33,269 Followers  |  3,160 Following  |  4,700 Posts  |  Joined: 29.11.2023  |  2.2159

Latest posts by boghuma.bsky.social on Bluesky

11/ In conclusion
Multivalent vaccines are not riskier.
They’re tested more rigorously, protect more people with fewer barriers, and save lives efficiently.
Separating MMR or other combination vaccines wastes resources, undermines coverage, and solves a problem that doesn’t exist.

07.10.2025 15:19 β€” πŸ‘ 16    πŸ” 5    πŸ’¬ 2    πŸ“Œ 0

10/Why the myth persists:
- It sounds β€œcautious,” which people equate with safe.
- Anti-vaccine groups misuse technical terms like monovalent to sow doubt.
- Rapid COVID-19 vaccine updates created confusion about how formulation changes work.

07.10.2025 15:19 β€” πŸ‘ 14    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0

9/β€œMore antigens = more side effects”
- Large cohort studies show no correlation between antigen count & serious adverse events.
Mild effects (soreness, low-grade fever) occur w both mono- and multivalent vaccines & resolve quickly.
In fact, fewer injections often mean fewer local reactions overall.

07.10.2025 15:19 β€” πŸ‘ 10    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

8/ Senegal just introduced a six-in-one vaccine protecting infants against diphtheria, tetanus, pertussis, hepatitis B, polio, and Haemophilus influenzae b.This move⬆️ adherence, simplifies supply chains, and makes every healthcare visit count exactly the kind of innovation global programs need.

07.10.2025 15:19 β€” πŸ‘ 16    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0

7/ The public-health payoff is big because combination vaccines
- Reduce clinic visits and needle sticks.
- Improve on-time completion.
- Simplify logistics and cold-chain storage.
- Save costs that can be redirected to outreach and education.

07.10.2025 15:19 β€” πŸ‘ 14    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
Preview
Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system? - PubMed Recent surveys found that an increasing number of parents are concerned that infants receive too many vaccines. Implicit in this concern is that the infant's immune system is inadequately developed to...

6/
- A complete childhood vaccine schedule exposes a baby to fewer than 150 antigens total.
- A common cold exposes them to thousands.
The immune system is built for parallel processing, not single-tasking. There is no such thing as β€œvaccine overload.”
pubmed.ncbi.nlm.nih.gov/11773551/

07.10.2025 15:19 β€” πŸ‘ 16    πŸ” 7    πŸ’¬ 1    πŸ“Œ 1
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Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16–26 years: a randomised, double-blind trial The 9vHPV vaccine prevents infection, cytological abnormalities, high-grade lesions, and cervical procedures related to HPV 31, 33, 45, 52, and 58. Both the 9vHPV vaccine and qHPV vaccine had a simila...

5/ DTaP: Combined vaccine replaced three monovalent injections equal safety, better adherence.
pubmed.ncbi.nlm.nih.gov/33483215/
HPV-9 vaccine trial: >15 000 participants in trials; safety identical to earlier versions.
www.thelancet.com/journals/lan...

07.10.2025 15:19 β€” πŸ‘ 9    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0

4/ These standards are evaluated in large randomized trials and tracked for decades after rollout.
Here are examples:
- MMR: Over 500 million doses administered; no increase in serious adverse events vs. giving three separate shots.

07.10.2025 15:19 β€” πŸ‘ 11    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

3/How combination vaccines are tested:
Before licensing, manufacturers must show that:
Each antigen provokes the same immune response together as alone.No component interferes with another’s effectiveness.
Adverse-event rates are the same or lower than for separate injections.

07.10.2025 15:19 β€” πŸ‘ 11    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0

2/
- Monovalent vaccines protect against one strain or pathogen (e.g., Hepatitis B).
- Multivalent (combination) vaccines protect against several at once MMR, DTaP, or HPV-9.
Multivalent β‰  β€œrushed cocktail.” It’s a deliberate, data-driven design that broadens protection safely and efficiency.

07.10.2025 15:19 β€” πŸ‘ 13    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0

1/ The origin of the myth:
People assume β€œfewer components = safer.” It’s intuitive but scientifically wrong.
Your immune system encounters thousands of antigens every day from food, bacteria, and your own microbiome.
The few dozen antigens in vaccines even combined ones are trivial by comparison.

07.10.2025 15:19 β€” πŸ‘ 15    πŸ” 3    πŸ’¬ 1    πŸ“Œ 1

🧡 #MythBustingTuesday
The CDC reportedly floated separating the MMR into individual shots without any published evidence that doing so improves safety.
Let’s unpack why this myth persists, what the data show, and why countries like Senegal are moving in the opposite direction.

07.10.2025 15:19 β€” πŸ‘ 60    πŸ” 31    πŸ’¬ 3    πŸ“Œ 1

I banked it for future use when someone says some foolishness hahaha

07.10.2025 11:46 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Thank you so much.

07.10.2025 02:20 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I promise I wasn't fishing for a complement 😊 LOL , thanks so much, it means alot and I admire you too!

07.10.2025 02:17 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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I hard co-sign this one.

07.10.2025 02:11 β€” πŸ‘ 515    πŸ” 131    πŸ’¬ 11    πŸ“Œ 7

Yup!

06.10.2025 21:03 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

πŸ‘Ή Evil Bunny
πŸ˜‚

06.10.2025 21:03 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Vaccine disinformation/misinformation is as damaging as banning vaccines because it accomplishes the same thing i.e. fewer people get vaccinated as a result.
RFK. Jr's agenda doesn't need to explicitly take vaccines off shelves to meet its goals pseudoscience and misinformation are doing the job.

06.10.2025 20:53 β€” πŸ‘ 111    πŸ” 29    πŸ’¬ 3    πŸ“Œ 1

All this announcement accomplishes is consolidate the additional barriers that will make it more challenging for people to access safe and effective vaccines. It is a step backwards not forwards.

06.10.2025 19:41 β€” πŸ‘ 13    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Informed consent is an important and integral part of the vaccine delivery process. We are not forcibly vaccinating people anywhere. Even where mandates are in place people have the right to refuse and provide documentation for waivers.

06.10.2025 19:41 β€” πŸ‘ 17    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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The CDC says people must consult a health professional before COVID shot The Centers for Disease Control and Prevention accepted a controversial recommendation from outside vaccine advisers to tighten guidelines for the COVID vaccine.

The non scientist former venture capitalist now turned interim CDC interim director, rubber stamped the deeply flawed ACIP vaccine recommendations.
He also declared "informed consent is back" further undermining public trust in health providers and vaccines.
www.npr.org/2025/10/06/n...

06.10.2025 19:41 β€” πŸ‘ 40    πŸ” 13    πŸ’¬ 7    πŸ“Œ 3

The Nature Medicine paper also looked at all-cause dementia, not just Alzheimer’s.VZV can cause vasculopathy and neuroinflammation which may drive non-Alzheimer dementias too. So the antiviral null result doesn’t disprove the preventive signal seen with shingles vaccination.

06.10.2025 18:58 β€” πŸ‘ 9    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Another key difference:
1/ Target virus: The vaccine acts on VZV, which may indirectly reactivate HSV-1.
2/ Dose/exposure: Valacyclovir doses for HSV may not suppress VZV well in neurons.
3/ Outcome: Vaccines delay onset of dementia; antivirals tried to change progression of AD.

06.10.2025 18:58 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Think of it this way, Zoster vaccines stop viral sparks before the fire.Valacyclovir tries to spray water on a house that’s already burning.Viral triggers may initiate neuroinflammation years earlier but once amyloid, tau, and vascular injury are entrenched, antivirals can’t reverse it.

06.10.2025 18:58 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0

The valacyclovir RCT, by contrast, asked:
β€œIf we suppress herpes viruses after Alzheimer’s disease (AD) has begun, can we slow it?” It targeted mostly HSV-1, not VZV, and enrolled people with established AD.It found no effect and that’s not surprising.By that point, the damage is already underway.

06.10.2025 18:58 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Great question and it’s about when and what we’re targeting.
The new study above links VZV reactivation to higher dementia risk. Zoster vaccination, which prevents reactivation, was tied to lower dementia incidence.

06.10.2025 18:58 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Hahaha, you are indeed reading my mind.

06.10.2025 17:46 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

"Was silence not an option"
Ta-nehisi Coates

06.10.2025 17:20 β€” πŸ‘ 39    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

The idea that infections and chronic inflammation can shape neuro-degeneration is gaining traction.
This study adds powerful population-scale evidence that viral reactivation is a plausible, preventable contributor to dementia.
If you are β‰₯ 50, get vaccinated against shingles.

06.10.2025 16:46 β€” πŸ‘ 33    πŸ” 7    πŸ’¬ 1    πŸ“Œ 1

@boghuma is following 20 prominent accounts